Correlation between the Extent of Nodal Involvement and Survival following Groin Dissection for Carcinoma of the Penis

Ramamurthi, Ravi

doi:10.1111/j.1464-410x.1993.tb16273.x

Cited by 214 publications

(115 citation statements)

References 9 publications

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“…In our series of patients treated with total glansectomy, only one patient had inguinal lymph node metastases 18 months after surgery, whereas none had local relapse, and our crude disease-specific survival rate of 93.3% after a mean follow-up of 36 months is similar to that reported by others using conventional surgical treatment. 15,16 Moreover, at a mean follow-up of 36 months, our functional results were extremely satisfactory ( Figure 3). All patients were able to maintain their sexual activity with a favorable psychological impact starting from 3 months after surgery, with a range between 2 and 6 months.…”

Section: Figurementioning

confidence: 73%

Glansectomy with split-thickness skin graft for the treatment of penile carcinoma

et al. 2009

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Using our prospectively derived database, we identified 17 patients with squamous-cell carcinoma involving the glans penis, who were treated using organ-sparing surgery between March 2003 and January 2008. Of them, two were treated with partial glansectomy with primary glans closure, and 15 underwent total glans amputation and reconstruction of a new glans using a split-thickness skin graft (STSG). These 15 patients represent the subject of our study (mean age 51 years, range 42 to 59 years). Overall, two patients had early partial loss of the graft and of them, one required surgical regrafting. Two late complications occurred, consisting of one meatal stenosis and one postoperative phimosis. At a mean follow-up of 36 months, functional results were extremely satisfactory. All patients maintained their erectile function with good vaginal penetration starting from 3 months after surgery, with a range between 2 and 6 months. Orgasm and ejaculation were preserved in all patients, although reduced glans sensitivity was reported by all patients. No local recurrences were reported.

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Section: Figurementioning

confidence: 73%

Glansectomy with split-thickness skin graft for the treatment of penile carcinoma

et al. 2009

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“…Its etiology is not fully understood, but there is a strong association with poor hygienic conditions, phimosis and human papillomavirus (HPV) infection (2,3). Metastases from penile carcinoma usually spread through penile lymphatic vessels to regional nodes, especially the superfi cial and deep inguinal nodes, and subsequently to the iliac nodes within the pelvis.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis

Ornellas¹,

Ornellas²,

Chinello³

et al. 2012

Int. braz j urol.

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Purpose: To investigate the use of ClinProt technique to identify cancer markers in plasma of patients suffering from squamous cell carcinoma of the penis (SCCP). Materials and Methods: Plasma of 36 healthy subjects and 25 patients with penile carcinoma who underwent surgical treatment between June 2010 and June 2011 was collected and analyzed by the ClinProt/MALDI/ToF technique. Then the peptides were identifi ed from the C8 MB eluted fraction of patients' and control subjects' plasma by LIFT MS/MS. Results: A cluster of 2 peptides (A=m/z 1897.22 ± 9 Da and B=m/z 2021.99 ± 9 Da) was able to discriminate patients from control subjects. Cross validation analysis using the whole casuistic showed 62.5% and 86.76% sensitivity and specifi city, respectively. The cluster also showed very high sensitivity (100%) and specifi city (97%) for SCCP patients that died due to the disease. Furthermore, patients with lymph node involvement presented sensitivity and specifi city of 80% and 97%, respectively. These two peptides were identifi ed by the proteomic approach based on a MALDI-TOF/TOF as fragments of C3 (m/z 1896.17) and C4a/b (m/z 2021.26) complement proteins. Conclusions:The results showed that as the disease progresses, the fragments C3 and C4 A/B are less expressed in comparison with healthy subjects. These results may be useful as prognostic tools.

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“…Localized penile carcinoma carries a good prognosis after radical resection, but advanced disease has a very poor prognosis, with 5-year survival in patients with locoregional lymph node extension of only 5-30% [2][3][4][5]. Unfortunately, for metastatic penile SCC there are no effective chemotherapy regimens and the existing combined regimens are often limited by their toxicity profile.…”

Section: Introductionmentioning

confidence: 99%

Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma

et al. 2006

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OBJECTIVE To retrospectively evaluate the efficacy and toxicity of chemotherapy with cisplatinum, methotrexate and bleomycin (CMB) in the adjuvant and palliative setting, and its effect on survival in patients with locally advanced or metastatic penile carcinoma, which carries a very poor prognosis. PATIENTS AND METHODS Thirteen patients (mean age 54 years) with radically resected local and nodal disease (eight), metastatic disease (two) or metastatic recurrence (three) had chemotherapy with CMB between February 1996 and July 2003. In all, 45 treatment courses were given, with a mean (range) of 3.5 (2–6) courses per patient. RESULTS Three of the eight patients with adjuvant treatment showed no evidence of disease after a mean (range) of 54 (41–76) months, while four in this group died from disease progression after a mean of 11 (5–20) months, and one died from treatment‐related toxicity. All five patients with metastatic disease died from disease progression after three had shown temporary signs of regression. CONCLUSIONS Chemotherapy with CMB had little effect on metastatic penile cancer and responses were transient. However, patients with minimal disease after radical local and lymphatic resection seemed to benefit from adjuvant therapy, but the toxicity was high and carried a risk of death.

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Correlation between the Extent of Nodal Involvement and Survival following Groin Dissection for Carcinoma of the Penis

Cited by 214 publications

References 9 publications

Glansectomy with split-thickness skin graft for the treatment of penile carcinoma

Glansectomy with split-thickness skin graft for the treatment of penile carcinoma

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis

Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma

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