2019
DOI: 10.1136/ijgc-2018-000032
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Correlation between the diversity of vaginal microbiota and the risk of high-risk human papillomavirus infection

Abstract: ObjectivesSince other genital infections enhance HIV susceptibility by inducing inflammation and evidence suggests that the vaginal microbiome plays a functional role in the persistence or regression of high-risk human papillomavirus (HPV) infections, we investigated the relationship between the composition of the vaginal microbiota and the risk of high-risk HPV infection.MethodsThe study included 151 healthy women (65 HPV-positive and 86 HPV-negative) aged 20–65 at enrollment. Total genome DNA from samples wa… Show more

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Cited by 61 publications
(51 citation statements)
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“…Similarly to the previous studies [2,4,17,18,23,24,40,42,47], we found increased abundances of several anaerobic bacteria such as Prevotella, Bacillus, Anaerococcus, Sneathia, Megasphaera, Streptococcus and Anaerococcus in HPV-infected women. We recognized Megasphaera of Firmicutes phylum as the most signi cant genus related with HPV infection, while Lee et al identi ed Sneathia spp.…”
Section: Discussionsupporting
confidence: 89%
“…Similarly to the previous studies [2,4,17,18,23,24,40,42,47], we found increased abundances of several anaerobic bacteria such as Prevotella, Bacillus, Anaerococcus, Sneathia, Megasphaera, Streptococcus and Anaerococcus in HPV-infected women. We recognized Megasphaera of Firmicutes phylum as the most signi cant genus related with HPV infection, while Lee et al identi ed Sneathia spp.…”
Section: Discussionsupporting
confidence: 89%
“…In contrast, Lactobacillus is not the sole genus that dominates vaginal microbiota in black and Hispanic women (only 59.6% and 61.9%, respectively) [ 10 ]. A cross-sectional study of 151 women (65 HPV-positive, 86 HPV-negative) revealed that HPV is significantly associated with higher abundance of anaerobes like Bacteroides plebeius , Acinetobacter lwoffii , and Prevotella buccae [ 59 ]. This finding implied that higher diversity of vaginal microbiota significantly increased the risk of HPV acquisition [ 59 ].…”
Section: Indigenous Vaginal Microbiota In Womenmentioning
confidence: 99%
“…A cross-sectional study of 151 women (65 HPV-positive, 86 HPV-negative) revealed that HPV is significantly associated with higher abundance of anaerobes like Bacteroides plebeius , Acinetobacter lwoffii , and Prevotella buccae [ 59 ]. This finding implied that higher diversity of vaginal microbiota significantly increased the risk of HPV acquisition [ 59 ]. It is conceivable that disrupted vaginal microbiota may affect the host innate immunity against HPV infection that leads to development of cervical cancer [ 60 ].…”
Section: Indigenous Vaginal Microbiota In Womenmentioning
confidence: 99%
“…We previously reported that increased CIN disease severity is associated with decreasing relative abundance of Lactobacillus spp. 14 , however, the cross-sectional nature of these datasets did not permit exploration on the impact that that VMB composition may have on clinical outcome of CIN and HPV infection clearance [11][12][13][14][16][17][18][19][20] . In an earlier study by Brotman et al 11 serial sampling of women over the course of 16 weeks suggested that Lactobacillus gasseri-dominant communities may promote clearance of acute HPV infection.…”
mentioning
confidence: 99%