Correlation between the circadian sleep propensity rhythm and hormonal rhythms under ultra‐short sleep–wake cycle

Abstract

The aim of this study was to clarify effects of hormonal and temperature rhythms on circadian fluctuations of sleep propensity. Ten healthy females underwent 24-h sleep deprivation and entered the circadian sleep propensity assessment setting under the ultra-short sleep-wake schedule. During the experiment, sleep propensity rhythm, rectal temperature, and 24-h serum hormone profiles (melatonin, cortisol and thyroid-stimulating hormone) were investigated. The circadian sleep propensity rhythms had two apparent peaks (afternoon and nocturnal peaks) and a trough (nocturnal sleep gate). The timings of the nocturnal sleep gate and the nocturnal peak were correlated exclusively with temperature and melatonin rhythms (P < 0.05), while that of the afternoon peak was significantly correlated with habitual wake time and melatonin rhythm. These results indicate that the circadian sleep propensity rhythm is influenced not only by the circadian pacemaker, but also by sleep habit.

Late, but not early, wake therapy reduces morning plasma melatonin: Relationship to mood in Premenstrual Dysphoric Disorder

“…Our results also contrast with studies that reported no effect of sleep deprivation on melatonin secretion (Jimerson et al, 1977; Touitou et al, 1992; von Treuer et al, 1996; Leproult et al, 1997; Goichot et al, 1998; Kudo et al, 1999; Redwine et al, 2000), and studies showing melatonin amplitude, but not phase, changes (Akerstedt et al, 1979; Salin-Pascual et al, 1988; Rao et al, 1996; Shilo et al, 1999; Goh et al, 2001; Cajochen et al, 2003). We cannot explain why the melatonin phase and amplitude results of our current study differ from our previous baseline studies.…”

“…Previous studies of the effects of wake therapy on melatonin amplitude measures showed primarily no effect (Jimerson et al, 1977; Touitou et al, 1992; von Treuer et al, 1996; Leproult et al, 1997; Goichot et al, 1998; Kudo et al, 1999; Redwine et al, 2000), although some observed an increase (Akerstedt et al, 1979; Salin-Pascual et al, 1988; Goh et al, 2001), and some a decrease (Rao et al, 1996; Shilo et al, 1999; Cajochen et al, 2003). These disparate results may be due to different methodologies employed, including the timing and frequency of the melatonin measurements in relation to sleep deprivation, light and activity conditions, the use of plasma versus urinary or salivary measures, the duration and timing of the change in sleep phase or sleep deprivation, and the method used to analyze melatonin amplitude or phase.…”

Association of salivary cortisol with chronomics of 24 hours ambulatory blood pressure/heart rate among night shift workers

“…Day sleep is light, fragmented, and more likely to be disrupted and hence, insomnia can be severe in night shift workers (5). It is possible that circadian sleep propensity rhythm and hormonal rhythm are under influence of the circadian pacemaker as well as sleep habits (6). Most rhythms are driven by an internal biological clock located in the hypothalamic suprachiasmatic nucleus and can be synchronized by external signals such as light-dark cycles (7).…”

Circadian Rhythms of Psychomotor Vigilance, Mood, and Sleepiness in the Ultra-Short Sleep/Wake Protocol

“…The ultra-short sleep/wake protocol has been used to establish circadian rhythms in melatonin (Kripke et al, 2005), sleep propensity (Kudo et al, 1999; Lavie et al, 1981), sleep architecture (Carskadon & Dement, 1975; Stampi, 1992), and neuroendocrine function (Weitzman et al, 1974a; Weitzman et al, 1974b), and to examine phase response curves for bright light (Kripke et al, 2007). However, the ultra-short sleep/wake protocol has been sparsely used in assessing circadian patterns of neurobehavioral performance and mood (Lavie et al, 1987).…”