Correlation between the bone mass of athletes and biochemical and genetic markers of bone tissue remodeling

Оганов, В. С.; Виноградова, О. Л.; Dudov, N S; Baranov, V. S.; Minenkov, A. S.; Бакулин, А. В.; Novikov, V. V.; Kabitskaya, O. E.; Москаленко, М. В.; Глотов, А. С.; Glotov, Oleg S.; Popov, D. V.

doi:10.1134/s0362119708020072

Cited by 3 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mutations were discriminated by analysing fluorescence intensities from separate units on the biochip, as previously described (Glotov et al 2007). Genotyping for the adenosine monophosphate deaminase 1 (AMPD1) Q12X (rs17602729), calcitonin receptor (CALCR) L447P (rs1801197), insulin-like growth factor 1 (IGF1) CA-repeat (rs10665874), myogenic factor 6 (MYF6) С964Т (rs3121), nitric oxide synthase 3 (NOS3) 27 bp repeat, thyroid stimulating hormone receptor (TSHR) D727E (rs1991517), vitamin D receptor (VDR) TaqI (rs731236) and vascular endothelial growth factor A (VEGFA) −2578 A/C (rs699947) gene polymorphisms was performed by PCR and restriction enzyme digestion (where appropriate), as previously described (Chistiakov et al 2002;Oganov et al 2008;Ahmetov et al 2009b;Fedotovskaya et al 2013;Zheng et al 2014).…”

Section: Genotypingmentioning

confidence: 99%

AGTR2 gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance

Mustafina

Наумов

Cięszczyk

et al. 2014

Experimental Physiology

View full text Add to dashboard Cite

New Findings r What is the central question of this study?Variations in genes are considered to be molecular determinants maintaining the expression of the slow or fast myosin heavy chains of adult skeletal muscle. The role of polymorphisms of candidate genes involved in skeletal muscle development, energy homeostasis and thyroid and calcium metabolism in the determination of muscle fibre type has not previously been reported. r What is the main finding and its importance?We show that the AGTR2 rs11091046 C allele is associated with an increased proportion of slow-twitch muscle fibres, endurance athlete status and aerobic performance. Such findings have important implications for our understanding of muscle function in both health and disease.Muscle fibre type is a heritable trait and can partly predict athletic success. It has been proposed that polymorphisms of genes involved in the regulation of muscle fibre characteristics may predispose the muscle precursor cells of a given individual to be predominantly fast or slow. In the present study, we examined the association between 15 candidate gene polymorphisms and muscle fibre type composition of the vastus lateralis muscle in 55 physically active, healthy men. We found that rs11091046 C allele carriers of the angiotensin II type 2 receptor gene (AGTR2; involved in skeletal muscle development, metabolism and circulatory homeostasis) had a significantly higher percentage of slow-twitch fibres than A allele carriers [54.2 (11.1) versus 45.2 (10.2)%; P = 0.003]. These data indicate that 15.2% of the variation in muscle fibre composition of the vastus lateralis muscle can be explained by the AGTR2 genotype. Next, we investigated the frequencies of the AGTR2 alleles in 2178 Caucasian athletes and 1220 control subjects. The frequency of the AGTR2 C allele was significantly higher in male and female endurance athletes compared with power athletes (males, 62.7 versus 51.7%, P = 0.0038; females, 56.6 versus 48.1%, P = 0.0169) and control subjects (males, 62.7 versus 51.0%, P = 0.0006; elite female athletes, 65.1 versus 55.2%, P = 0.0488). Furthermore, the frequency of the AGTR2 A allele was significantly over-represented in female power athletes (51.9%) in comparison to control subjects (44.8%, P = 0.0069). We also found that relative maximal oxygen consumption was significantly greater in male endurance athletes with the AGTR2 C allele compared with AGTR2 A allele carriers [n = 28; 62.3 (4.4) versus 57.4 (6.0) ml min −1 kg −1 ; P = 0.0197]. Taken together, these results demonstrate that the AGTR2 gene C allele is associated with an increased proportion of slow-twitch muscle fibres, endurance athlete status and aerobic performance, while the A allele is associated with a higher percentage of fast-twitch fibres and power-oriented disciplines.

show abstract

Section: Genotypingmentioning

confidence: 99%

AGTR2 gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance

Mustafina

Наумов

Cięszczyk

et al. 2014

Experimental Physiology

View full text Add to dashboard Cite

show abstract

The impact of different types of physical activity on total and regional bone mineral density in young Brazilian athletes

Silva

Goldberg

Teixeira

et al. 2011

Journal of Sports Sciences

View full text Add to dashboard Cite

Bone turnover is affected by exercise throughout the lifespan, especially during childhood and adolescence. The objective of this study was to investigate the impact of different sports on total and regional bone mineral density in male Brazilian adolescent athletes. Forty-six adolescents aged 10-18 years participated in the study: 12 swimmers, 10 tennis players, 10 soccer players, and 14 sedentary individuals. The athletes had engaged in physical activities for more than 10 h per week in the previous 6 months. Bone mineral density of the lumbar spine (L1-L4), left proximal femur region, and whole body was evaluated by dual-energy X-ray absorptiometry. Results showed higher mean values in the proximal femur region of tennis and soccer players (1.02 ± 0.18; 0.96 ± 0.16, respectively) than swimmers and controls (0.91 ± 0.14 and 0.87 ± 0.06, respectively) (P < 0.05). In relation to the impact of sporting activities based on bone age determination, we observed significant differences in bone mineral density at all evaluated sites at the end of puberty (16-18 years) compared with 10-12 years, with increases of 78% in the lumbar spine, 47% in the proximal femur, and 38% in the whole body.

show abstract

Influence of professional sports activities on bone mineral density (<i>literature review</i>)

Nikitina,

Vykhodets,

Abramova

et al. 2024

Rossijskij osteopaticheskij zhurnal

View full text Add to dashboard Cite

Introduction. The positive effect of physical activity on the state of bone has been proven by many researchers. Professional sports activity is a model of the constant impact of physical activity on the human body, acting as the most powerful mechanism for activating and mobilizing the functional reserves of an athlete, which, against the background of a progressive increase in the volume, intensity and duration of exposure, shows an increase in the incidence of injuries and stress fractures, one of the leading causes of which is a decrease in bone mineral density (BMD) up to the development of osteoporosis. The risk factors for the development of the pathology of the musculoskeletal system, which have a direct impact on the formation of the BMD, in elite sports include the volume and intensity of training loads, the stereotype of the main competitive exercise, the daily balance of energy intake.The aim is to study is to analyze modern scientific publications on the impact of professional sports activities on bone mineral density.Materials and methods. The review is based on publications from the PubMed, Google Scholar, Cyberleninka, eLIBRARY databases. Preference was given to articles published in refereed sources over the past 10 years.Results. The specificity of the main competitive exercise determines the presence of asymmetry in the distribution of the BMD in athletes, in addition, the level of BMD is higher in the leading limb compared to the opposite. Increasing the qualifications, experience and age of an athlete shows a positive impact on the performance of the BMD, with the exception of certain specializations. A different effect of sports with a high osteogenic effect of shock and weight load on the state of the BMD was noted compared to the general population. Power athletes, combat and game sports athletes have higher levels BMD compared to representatives of cycling, swimming, rowing, triathlon and long-distance running, characterized by the limitation of gravitational (shock) load or a large amount of low-intensity training exposure. Lower BMD were noted in athletes in sports specializations with weight categories, aesthetic and cyclic sports, where the problem of a relative energy deficiency in sport, which negatively affects bone metabolism.Conclusions. In athletes, the volume and intensity of training loads, the stereotype of performing the main competitive exercise, the daily balance of energy intake have a direct impact on the formation of the BMD with the allocation of risk groups for the pathology of the musculoskeletal system in elite sports.

show abstract

Correlation between the bone mass of athletes and biochemical and genetic markers of bone tissue remodeling

Cited by 3 publications

References 16 publications

AGTR2 gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance

AGTR2 gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance

The impact of different types of physical activity on total and regional bone mineral density in young Brazilian athletes

Influence of professional sports activities on bone mineral density (<i>literature review</i>)

Contact Info

Product

Resources

About