Correlation between the Bone Density Recorded by a Computerized Implant Motor and by a Histomorphometric Analysis: A Preliminary In Vitro Study on Bovine Ribs

Iezzi, Giovanna; Scarano, Antonio; Stefano, Danilo Alessio Di; Arosio, Paolo; Doi, Katsuhiko; Ricci, Laura; Piattelli, Adriano

doi:10.1111/cid.12121

Cited by 23 publications

(36 citation statements)

References 29 publications

(55 reference statements)

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“…A previous study found a significant linear correlation between immediate BIC and BMD at the placement site33, which explains the increase in the initial BIC caused by the high BMD in this study. In addition, the average torque values, which reflect bone strength, are known to be significantly correlated with histological bone density data34.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Hao

et al. 2017

Sci Rep

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The bone mineral deficiency in osteoporosis poses a threat to the long-term outcomes of endosseous implants. The inhibitors of cathepsin K (CatK) significantly affect bone turnover, bone mineral density (BMD) and bone strength in the patients with osteoporosis. Therefore, we hypothesised that the application of a CatK inhibitor (CatKI) could increase the osseointegration of endosseous implants under osteoporotic conditions. Odanacatib (ODN), a highly selective CatKI, was chosen as the experimental drug. Sixteen rats were randomised into 4 groups: sham, ovariectomy (OVX) with vehicle, OVX with low-dose ODN (5 mg/kg) and OVX with high-dose ODN (30 mg/kg). Titanium implants were placed into the distal metaphysis of bilateral femurs of each OVX rat. After 8 weeks of gavaging, CatKI treatment increased the removal torque, BMD and bone-to-implant contact (BIC). Moreover, high-dose CatKI exerted a better influence than low-dose CatKI. Furthermore, CatKI treatment not only robustly suppressed CatK gene (CTSK) expression, but also moderately reduced expression of the osteoblast-related genes Runx2, Collagen-1, BSP, Osterix, OPN, SPP1 and ALP. Thus, CatKI could affect the osteoblast-related genes, although the balance of bone turnover was achieved mainly by CatK inhibition. In conclusion, CatKI prevented bone loss and aided endosseous implantation in osteoporotic conditions.

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Section: Discussionmentioning

confidence: 99%

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Hao

et al. 2017

Sci Rep

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“…This might be reconsidered once implant-motors as described by Iezzi G. et al 21 are generally available.…”

Section: Discussionmentioning

confidence: 99%

“…Iezzi G. et al 21 2013 introduced a computerized implant motor recording ITVs at implant insertion and experimentally found a close correlation between the ITVs recorded by this device and the later histomorphometric analysis pf bone density.…”

mentioning

confidence: 99%

Primary implant stability in augmented sinuslift-sites after completed bone regeneration: a randomized controlled clinical study comparing four subantrally inserted biomaterials

Troedhan¹,

Schlichting

Kurrek³

et al. 2014

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Implant-Insertion-Torque-Value (ITV) proved to be a significant clinical parameter to predict long term implant success-rates and to decide upon immediate loading. The study evaluated ITVs, when four different and commonly used biomaterials were used in sinuslift-procedures compared to natural subantral bone in two-stage-implant-procedures. The tHUCSL-INTRALIFT-method was chosen for sinuslifting in 155 sinuslift-sites for its minimal invasive transcrestal approach and scalable augmentation volume. Four different biomaterials were inserted randomly (easy-graft CRYSTAL n = 38, easy-graft CLASSIC n = 41, NanoBone n = 42, BioOss n = 34), 2 ccm in each case. After a mean healing period of 8,92 months uniform tapered screw Q2-implants were inserted and Drill-Torque-Values (DTV) and ITV were recorded and compared to a group of 36 subantral sites without need of sinuslifting. DTV/ITV were processed for statistics by ANOVA-tests. Mean DTV/ITV obtained in Ncm were: Control Group 10,2/22,2, Bio-Oss 12,7/26,2, NanoBone 17,5/33,3, easy-graft CLASSIC 20,3/45,9, easy-graft CRYSTAL 23,8/56,6 Ncm, significance-level of differences throughout p < 0,05. Within the limits of this study the results suggest self-hardening solid-block-like bone-graft-materials to achieve significantly better DTV/ITV than loose granulate biomaterials for its suspected improvement of vascularization and mineralization of the subantral scaffold by full immobilization of the augmentation site towards pressure changes in the human sinus at normal breathing.

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“…A study on bovine ribs has shown that the device provides reliable bone density values, significantly correlating with actual histomorphometric data. 23 When used on patients, the device enabled zones of the jaws with different bone densities to be distinguished. 24 Additionally, the device allows instantaneous insertion torque and other correlated values to be recorded at the time of implant placement.…”

Section: 5005/jp-journals-10024-1743mentioning

confidence: 99%

“…It has also been shown that the torque-depth function integral the device provides at implant insertion, correlates with immediate boneto-implant contact (BIC) at insertion in experiments on bovine ribs, later confirmed by observations on human subjects. 23,25 The device, therefore, seems to convey pivotal information to the surgeon; both, immediately before implant placement, helping to design a proper implantinsertion intraoperative strategy, and just after insertion, allowing assessment of the primary stability achieved. In this study, a case is presented in which bone density data were acquired using both conventional CT scans and the torque-measuring system, in order to get an inthe-field assessment of the advantages provided by the device, if any.…”

Section: 5005/jp-journals-10024-1743mentioning

confidence: 99%

An Intraoperative Site-specific Bone Density Device: A Pilot Test Case

Arosio

Moschioni

Banfi

et al. 2015

The Journal of Contemporary Dental Practice

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Aim: This paper reports a case of all-on-four rehabilitation where bone density at implant sites was assessed both through preoperative computed tomographic (CT) scans and using a micromotor working as an intraoperative bone density measurement device.Background: Implant-supported rehabilitation is a predictable treatment option for tooth replacement whose success depends on the clinician's experience, the implant characteristics and location and patient-related factors. Among the latter, bone density is a determinant for the achievement of primary implant stability and, eventually, for implant success. The ability to measure bone density at the placement site before implant insertion could be important in the clinical setting.Case description: A patient complaining of masticatory impairment was presented with a plan calling for extraction of all her compromised teeth, followed by implant rehabilitation. A week before surgery, she underwent CT examination, and the bone density on the CT scans was measured. When the implant osteotomies were created, the bone density was again measured with a micromotor endowed with an instantaneous torque-measuring system. The implant placement protocols were adapted for each implant, according to the intraoperative measurements, and the patient was rehabilitated following an all-on-four immediate loading protocol. An Conclusion:The bone density device provided valuable information beyond that obtained from CT scans, allowing for site-specific, intraoperative assessment of bone density immediately before implant placement and an estimation of primary stability just after implant insertion.Clinical significance: Measuring jaw-bone density could help clinicians to select implant-placement protocols and loading strategies based on site-specific bone features.

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Correlation between the Bone Density Recorded by a Computerized Implant Motor and by a Histomorphometric Analysis: A Preliminary In Vitro Study on Bovine Ribs

Abstract: Within the limitations of this in vitro study, the intraoperative site-specific classification of bone density, obtained with this innovative system, could be helpful for the clinician to tailor the surgical protocol to the different situations in implant dentistry.

Cited by 23 publications

References 29 publications

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Primary implant stability in augmented sinuslift-sites after completed bone regeneration: a randomized controlled clinical study comparing four subantrally inserted biomaterials

An Intraoperative Site-specific Bone Density Device: A Pilot Test Case

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