Correlation Between Telomere Length and Biomarkers of Oxidative Stress in Human Aging

Yadav, Somu; Maurya, Pawan Kumar

doi:10.1089/rej.2021.0045

Cited by 20 publications

(20 citation statements)

References 31 publications

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“…33 A recent study with 105 healthy subjects of both sexes between the ages of 20-77 years showed a significant (p < .001) age-dependent decline in rTL. 34 There was no significant difference between telomere length in males and females in alignment with the reported data. Ours is the first Indian study to establish age-wise relative telomere length in a large normal population.…”

Section: Discussionsupporting

confidence: 88%

“…There was no significant difference between gender and telomere length 33 . A recent study with 105 healthy subjects of both sexes between the ages of 20–77 years showed a significant ( p < .001) age‐dependent decline in rTL 34 . There was no significant difference between telomere length in males and females in alignment with the reported data.…”

Section: Discussionsupporting

confidence: 77%

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Comparison of telomere length in patients with bone marrow failure syndromes and healthy controls

Barade,

Lakshmi,

Korula

et al. 2024

European J of Haematology

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IntroductionDuring normal aging, telomeric DNA is gradually lost in dividing somatic cells, and critically short telomeres lead to replicative senescence, apoptosis, or chromosomal instability. We studied telomere length in bone marrow failure syndromes (BMFS) compared to normal healthy population.MethodsPeripheral blood was collected from the participants, and genomic DNA was extracted. Relative telomere length was measured using a quantitative polymerase chain reaction. Statistical analysis was performed using SPSS and GraphPad Prism 8.2 software.ResultsThe median age of normal Indian population was 31 (0–60) years. As expected, telomere length (TL) showed a decline with age and no difference in TL between males and females. The median age of 650 patients with aplastic anemia (AA) was 30 (1–60) years. TL was significantly shorter in patients with AA compared to healthy controls (p < .001). In FA and MDS patients, TL was significantly shorter than age‐matched healthy controls (p = .028; p < .001), respectively. There was no difference between the median TL in age‐matched AA and FA patients (p = .727). However, patients with MDS had shorter TL than age‐matched AA (p = .031).ConclusionTL in BMF syndrome patients was significantly shorter than age‐matched healthy controls.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 77%

Comparison of telomere length in patients with bone marrow failure syndromes and healthy controls

Barade,

Lakshmi,

Korula

et al. 2024

European J of Haematology

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“…Using telomere length as a vehicle to explore a robust methodology, our study wishes to build on previous ML studies in the epigenomics field by evaluating a range of feature-selection methods and ML algorithms to identify a novel DNA methylation-based estimator of TL and investigate its association with other health-related demographics. Telomere length—DNA repeat structures which are located at the ends of each chromosome and have a crucial role in maintaining genomic stability—has emerged as a promising biomarker for biological age [ 31 – 33 ]. In recent years an association between TL and epigenetic processes has been hypothesised.…”

Section: Introductionmentioning

confidence: 99%

A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator

et al. 2023

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Background The field of epigenomics holds great promise in understanding and treating disease with advances in machine learning (ML) and artificial intelligence being vitally important in this pursuit. Increasingly, research now utilises DNA methylation measures at cytosine–guanine dinucleotides (CpG) to detect disease and estimate biological traits such as aging. Given the challenge of high dimensionality of DNA methylation data, feature-selection techniques are commonly employed to reduce dimensionality and identify the most important subset of features. In this study, our aim was to test and compare a range of feature-selection methods and ML algorithms in the development of a novel DNA methylation-based telomere length (TL) estimator. We utilised both nested cross-validation and two independent test sets for the comparisons. Results We found that principal component analysis in advance of elastic net regression led to the overall best performing estimator when evaluated using a nested cross-validation analysis and two independent test cohorts. This approach achieved a correlation between estimated and actual TL of 0.295 (83.4% CI [0.201, 0.384]) on the EXTEND test data set. Contrastingly, the baseline model of elastic net regression with no prior feature reduction stage performed less well in general—suggesting a prior feature-selection stage may have important utility. A previously developed TL estimator, DNAmTL, achieved a correlation of 0.216 (83.4% CI [0.118, 0.310]) on the EXTEND data. Additionally, we observed that different DNA methylation-based TL estimators, which have few common CpGs, are associated with many of the same biological entities. Conclusions The variance in performance across tested approaches shows that estimators are sensitive to data set heterogeneity and the development of an optimal DNA methylation-based estimator should benefit from the robust methodological approach used in this study. Moreover, our methodology which utilises a range of feature-selection approaches and ML algorithms could be applied to other biological markers and disease phenotypes, to examine their relationship with DNA methylation and predictive value.

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“…The multiple targets and modes of action of CeVO 4 NPs, such as cell wall disruption, oxidative stress induction, and enzyme inhibition, make them less prone to resistance development. 101 Microorganisms are less likely to develop resistance against CeVO 4 NPs due to the multifaceted nature of their antimicrobial effects. Lastly, CeVO 4 NPs can be tailored to achieve specificity towards specific microbial strains or infections.…”

Section: Advantages Of Cevo 4 Nps Over Conventional Antibiotics or An...mentioning

confidence: 99%

Biomedical applications of cerium vanadate nanoparticles: a review

Farasati Far,

Maleki-baladi,

Fathi-karkan

et al. 2024

J. Mater. Chem. B

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Correlation Between Telomere Length and Biomarkers of Oxidative Stress in Human Aging

Cited by 20 publications

References 31 publications

Comparison of telomere length in patients with bone marrow failure syndromes and healthy controls

Comparison of telomere length in patients with bone marrow failure syndromes and healthy controls

A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator

Biomedical applications of cerium vanadate nanoparticles: a review

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