Correlation between Systemic Lupus Erythematosus Disease Activity Index, C3, C4 and Anti-dsDNA Antibodies

Narayanan, K.; Marwaha, Vishal; Shanmuganandan, Krishnan; Shankar, S.

doi:10.1016/s0377-1237(10)80118-2

Cited by 42 publications

(30 citation statements)

References 9 publications

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“…Other investigators have reported an association of plasma parameters, such as anti-dsDNA, C3 and C4, with disease activity. Our findings on plasma levels of anti-dsDNA, C3 and C4 and their correlation with the SLEDAI scores (Figure 2B, C and 2D) are in conformity to earlier reports [27,28]. The SLEDAI scores correlated positively with dsDNA antibody levels ( P = 0.002, r = 0.31), while it correlated negatively with C3 ( P < 0.0001, r = -0.39) and C4 (P = 0.0003, r = -0.40) respectively.…”

Section: Resultssupporting

confidence: 93%

Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

et al. 2012

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IntroductionA role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we investigated MBL as a potential biomarker for disease activity in SLE.MethodsIn a case control study SLE patients (93 females) and 67 age, sex, ethnicity matched healthy controls were enrolled. Plasma MBL levels were quantified by enzyme linked immunosorbent assay (ELISA). Clinical, serological and other markers of disease activity (C3, C4 and anti-dsDNA) were measured by standard laboratory procedures.ResultsPlasma MBL levels were significantly high in SLE patients compared to healthy controls (P < 0.0001). MBL levels were variable in different clinical categories of SLE. Lower levels were associated with musculoskeletal and cutaneous manifestations (P = 0.002), while higher and intermediate MBL levels were significantly associated with nephritis in combination with other systemic manifestations (P = 0.01 and P = 0.04 respectively). Plasma MBL correlated with systemic lupus erythematosus disease activity index (SLEDAI) (P = 0.0003, r = 0.36), anti-dsDNA (P < 0.0001, r = 0.54), proteinuria (P < 0.0001, r = 0.42) and negatively correlated with C3 (P = 0.007, r = -0.27) and C4 (P = 0.01, r = -0.29).ConclusionsPlasma MBL is a promising marker in the assessment of SLE disease activity.

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Section: Resultssupporting

confidence: 93%

Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

et al. 2012

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“…A study by Narayanan et al [29] have reported significantly high levels of anti-dsDNA, with lowest C3 and C4 levels in renal flare cases, as compared to non-renal flare cases. In addition, SLEDAI was positively correlated with anti-dsDNA and negatively correlated to C3 and C4 levels in renal flares, whereas no significant association was found among non-renal flare cases.…”

Section: Discussionmentioning

confidence: 99%

Elevated interleukin-25 and its association to Th2 cytokines in systemic lupus erythematosus with lupus nephritis

et al. 2019

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Systemic lupus erythematosus (SLE) is an autoimmune disorder that is associated with lupus nephritis, initiated by the deposition of immune complexes in the kidney; subsequently, this induces the overexpression of cytokines. Lupus nephritis is known as one of the major clinical manifestations that affect the disease severity in SLE patients. An increased number of resident periglomerular and immune cells in the kidney has the potential to affect the equilibrium of different immune cell subsets, such as Th1, Th2, Th17, and Tregs, which may be central to the induction of tissue damage in kidney by exerting either proinflammatory or anti-inflammatory effects, or both. This equilibrium has yet to be confirmed, as new players such as IL-25 remain undiscovered. IL-25 is a cytokine of the IL-17 family, which stimulates Th2-mediated immune response when overly expressed. Thus, the aim of this research is to determine the plasma levels of IL-25 and Th2-associated cytokines (IL-4, IL-5, IL-6, IL-9, IL-10, IL-13) in SLE patients with (SLE-LN) and without lupus nephritis. Sixty-four (n = 64) SLE patients and fifteen (n = 15) healthy individuals were recruited. This study demonstrated that the IL-9, IL-10 and IL-25 had significantly increased expressions in SLE-LN, followed by SLE without LN, compared to healthy controls. Meanwhile, IL-5 and IL-6 had significantly reduced. No significant difference was observed with IL-13, while the level of IL-4 was undetectable. Furthermore, IL-9 and IL-10 were significantly correlated with the IL-25, and IL-25, IL-9 and IL-10 were positively correlated with the disease severity score, SLEDAI. In conclusion, IL-25 and its associated Th2 cytokines (IL-9 and IL-10) may be involved in SLE pathogenesis. These cytokines could be potential biomarkers in monitoring and predicting the disease severity during SLE pathogenesis.

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“…This indicates that more male patients in Jordan have LN than in other countries (neighboring and nonneighboring). This difference may be related to specific differences in pathogenesis among sexes, including genetic, hormonal, and immune-responses factors, in addition to racial and geographical variations in LN [18]. Further studies are warranted to establish the causes of the increased prevalence of LN among males in Jordan.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Histological Types of Lupus Nephritis in a Jordanian Tertiary Medical Center

Farah

Dannoun

Shahin

et al. 2019

BioMed Research International

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Objectives. Few reports of lupus nephritis (LN) from Jordan and the Middle East exist. This study assessed the demographic, clinical, and basic laboratory characteristics of Jordanian patients with LN and correlations with the histological class of LN. Methods. This was a retrospective study of all patients who underwent kidney biopsy between 2007 and 2018 at a tertiary medical center in Jordan. Patients’ demographic, clinical, laboratory, and pathological data were reviewed. Results. In total, 79 patients were included in this study [mean age, 29.95 ± 12.16 years; 11 men (13.9%), 68 women (86.1%)]. Asymptomatic proteinuria and hematuria were the most common presentations in LN patients at biopsy (59.5%). The study revealed a significant difference in frequency of nephritic syndrome (p= 0.01) between sexes (10.3% female vs. 45.5% male). Class IV was the most common pathological class of LN [37 (46.8%)], followed by class V [15 (19%)] and class III [10 (12.7%)]. Post hoc analysis of the associations between laboratory values and histopathological patterns revealed a significant correlation between class IV lupus and renal failure (p= 0.018) and class IV lupus and anti-DNA antibodies p= 0.030). End-stage renal disease (ESRD) occurred in 25% of lupus nephritis cases. There was an increased likelihood of ESRD among men than women (45% vs. 22%). Overall mortality was 10%. Conclusion. Although some clinical and laboratory findings correlate with histological types of LN, clinical and laboratory parameters of Jordanian patients with LN are not predictive of the histological type, although differences with regional studies were noted.

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Correlation between Systemic Lupus Erythematosus Disease Activity Index, C3, C4 and Anti-dsDNA Antibodies

Cited by 42 publications

References 9 publications

Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

Elevated interleukin-25 and its association to Th2 cytokines in systemic lupus erythematosus with lupus nephritis

Characteristics and Histological Types of Lupus Nephritis in a Jordanian Tertiary Medical Center

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