Correlation between synergistic action of Radix Angelica dahurica extracts on analgesic effects of Corydalis alkaloid and plasma concentration of dl-THP

Liu, Zuliang; Liang, Xin-Li; Zhu, Jing-Yun; Zhao, Guowei; Yang, Ming; Wang, Guangfa; Jiang, Qie-Ying; Chen, Xulong

doi:10.1016/j.jep.2010.03.005

Cited by 42 publications

(25 citation statements)

References 14 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, Yan-Hu-Suo has been used to promote blood circulation, alleviate amenorrhea and dysmenorrhea, and treat puerperal blood stasis [25]. Tetrahydroprotoberberines (THPBs), isolated from Yan-Hu-Suo, was demonstrated to suppress D2 dopamine receptors in the central nervous system to exert analgesic effect [26].…”

Section: Discussionmentioning

confidence: 99%

The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study

Lin

Chiang

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundMany patients with gynecological disorders seek traditional medicine consultations in Asian countries. This study intended to investigate the utilization of traditional Chinese medicine (TCM) in patients with dysfunctional uterine bleeding (DUB) in Taiwan.MethodsWe analyzed a cohort of one million individuals randomly selected from the National Health Insurance Research Database in Taiwan. We included 46,337 subjects with newly diagnosed DUB (ICD-9-CM codes 626.8) from January 1, 1997 to December 31, 2010. The patients were categorized into TCM seekers and non-TCM seekers according to their use of TCM.ResultsAmong the subjects, 41,558 (89.69%) were TCM seekers and 4,779 (10.31%) were non-TCM seekers. Patients who were younger tended to be TCM seekers. Most of the patients had also taken Western medicine, especially tranexamic acid and non-steroidal anti-inflammatory drugs (NSAIDs). More than half of TCM seekers (55.41%) received combined treatment with both Chinese herbal remedies and acupuncture. The most commonly used TCM formula and single herb were Jia-Wei-Xiao-Yao-San (Bupleurum and Peony Formula) and Yi-Mu-Cao (Herba Leonuri), respectively. The core pattern of Chinese herbal medicine for DUB patients consisted of Jia-Wei-Xiao-Yao-San, Xiang-Fu (Rhizoma Cyperi), and Yi-Mu-Cao (Herba Leonuri).ConclusionsTCM use is popular among patients with DUB in Taiwan. Further pharmacological investigations and clinical trials are required to validate the efficacy and safety of these items.

show abstract

Section: Discussionmentioning

confidence: 99%

The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study

Lin

Chiang

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…In the practice of TCM, since long time, YZP has been used as an analgesic agent; some animal experiments indicated that YZP possesses the pharmacological action of analgesic [53, 54]. The present study indicated that YZP possesses multipharmacology molecular attributes through different target groups such as opioid receptors, dopamine receptors, and calcium channel.…”

Section: Resultsmentioning

confidence: 57%

A Computational Drug-Target Network for Yuanhu Zhitong Prescription

Tao

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Yuanhu Zhitong prescription (YZP) is a typical and relatively simple traditional Chinese medicine (TCM), widely used in the clinical treatment of headache, gastralgia, and dysmenorrhea. However, the underlying molecular mechanism of action of YZP is not clear. In this study, based on the previous chemical and metabolite analysis, a complex approach including the prediction of the structure of metabolite, high-throughput in silico screening, and network reconstruction and analysis was developed to obtain a computational drug-target network for YZP. This was followed by a functional and pathway analysis by ClueGO to determine some of the pharmacologic activities. Further, two new pharmacologic actions, antidepressant and antianxiety, of YZP were validated by animal experiments using zebrafish and mice models. The forced swimming test and the tail suspension test demonstrated that YZP at the doses of 4 mg/kg and 8 mg/kg had better antidepressive activity when compared with the control group. The anxiolytic activity experiment showed that YZP at the doses of 100 mg/L, 150 mg/L, and 200 mg/L had significant decrease in diving compared to controls. These results not only shed light on the better understanding of the molecular mechanisms of YZP for curing diseases, but also provide some evidence for exploring the classic TCM formulas for new clinical application.

show abstract

“…Although the total coumarins and volatile oil as the major active constitutes of Angelicae Dahuricae Radix showed rarely analgesic effects, many studies have demonstrated that both total coumarins and volatile oil could increase the analgesic effect of Corydalis alkaloids. By detecting the dl-THP plasma concentration of several groups at different time intervals in rats, researchers found that co-administration of total coumarins and/ or volatile oil could markedly elevate the plasma concentration of dl-THP when compared with free Corydalis alkaloids (Liao et al, 2010), which indicated that Angelicae Dahuricae Radix may work as an absorption enhancer in this formula.…”

Section: Herb Compatibility Is a Better Choicementioning

confidence: 99%

Compatibility art of traditional Chinese medicine: From the perspective of herb pairs

Sheng-peng

Tan

et al. 2012

Journal of Ethnopharmacology

257

158

View full text Add to dashboard Cite

Correlation between synergistic action of Radix Angelica dahurica extracts on analgesic effects of Corydalis alkaloid and plasma concentration of dl-THP

Cited by 42 publications

References 14 publications

The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study

The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study

A Computational Drug-Target Network for Yuanhu Zhitong Prescription

Compatibility art of traditional Chinese medicine: From the perspective of herb pairs

Contact Info

Product

Resources

About