Correlation between Symptoms and Laryngeal Signs in Laryngopharyngeal Reflux

Qadeer, Mohammed A.; Swoger, Jason M.; Milstein, Claudio F.; Hicks, Douglas M.; Ponsky, Jeff; Richter, Joel E.; Abelson, Tom I.; Vaezi, Michael F.

doi:10.1097/01.mlg.0000176547.90094.ac

Cited by 100 publications

(91 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, many such studies were either observational or had short-term followup. Therefore, Qadeer et al [9] from Mayo Clinic, USA conducted subgroup analysis of a prospective concurrent controlled study with one year follow-up to ascertain the correlation between signs and symptoms. They found very poor correlation between signs and symptoms of LPR, particularly when monitoring therapeutic outcomes.…”

Section: Discussionmentioning

confidence: 99%

Concordance between Symptoms Reported By Patients and Signs Elicited By Orthopedic Surgeons

Hussain¹,

Bashir²,

Rehan³

2018

BJSTR

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Concordance between Symptoms Reported By Patients and Signs Elicited By Orthopedic Surgeons

Hussain¹,

Bashir²,

Rehan³

2018

BJSTR

View full text Add to dashboard Cite

“…Diberikan cairan penghenti, kemudian hasil dibaca pada spektrofotometer. Hasil diinterpretasikan sebagai negatif bila OD450<0,140 dan positif bila OD450>0,160 16 Subjek dengan hasil HpSA positif kemudian dibagi dalam dua kelompok. Kelompok pertama diberikan terapi lansoprazol 2x30 mg, amoksisilin 2x1 g, dan klaritromisin 2x500 mg selama 14 hari.…”

Section: -4unclassified

“…Laring lebih sensitif sekitar 100 kali terhadap kerusakan oleh pepsin dibandingkan dengan esofagus dan tiga kali episode refluks per minggu sudah mampu menyebabkan kerusakan laring yang signifikan. 2,3,16 Pada penelitian didapatkan sekret di belakang hidung pada semua penderita. Keluhan sekret di belakang hidung atau post nasal drip berhubungan dengan terpaparnya faring dan nasofaring oleh refluks asam yang menimbulkan sensasi sekret di belakang hidung atau sensasi hidung tersumbat, serta akan meningkatkan keadaan sekresi nasal.…”

Section: -3unclassified

“…Hal ini merupakan patogenesis GERD, sehingga pada refluks laringofaring kemungkinan keluhan nyeri dada/heartburn akan lebih tinggi dibandingkan dengan penderita refluks laringofaring tanpa infeksi H. pylori. 2,6,7,16 Pada kedua kelompok penelitian pascaterapi didapatkan perbaikan keluhan serak serta rasa mengganjal di tenggorokan yang lebih baik bila dibandingkan dengan kelompok perlakuan kombinasi antibiotik dan lansoprazol, sedangkan perbaikan gejala refluks lainnya tidak ditemukan perbedaan.Secara keseluruhan, perbaikan gejala didapatkan lebih baik pada kelompok perlakuan pertama.…”

Section: 17unclassified

See 1 more Smart Citation

Efektivitas Pemberian Antibiotik Disertai Lansoprazol pada Refluks Laringofaring dengan Infeksi Helicobacter pylori

Nurrokhmawati¹,

Madiadipoera²,

Anggraeni³

et al. 2012

mkb

View full text Add to dashboard Cite

AbstrakRefluks laringofaring adalah aliran balik isi lambung ke daerah laringofaring dan dapat dipengaruhi oleh infeksi Helicobacter pylori. Regimen terapi untuk infeksi H. pylori terdiri atas proton pump inhibitor (PPI) dan dua jenis antibiotik yaitu amoksisilin dan klaritromisin. Peran PPI pada regimen ini masih diteliti. Dilakukan penelitian mengenai perbandingan efektivitas terapi antibiotik disertai PPI (lansoprazol) terhadap perbaikan gejala klinis dan kualitas hidup penderita refluks laringofaring dengan infeksi H. pylori. The Effectiveness of Antibiotics with Lansoprazole in the Treatment of Laryngopharyngeal Reflux with Helicobacter pylori Infection AbstractLaryngopharyngeal Reflux (LPR) is a reflux of gastric content to the laryngopharyngeal and influenced by Helicobacter pylori infection. The treatment of H. pylori infection consists of proton pump inhibitor and two kinds of antibiotics, i.e. amoxicillin and clarithromycin. The role of PPI is currently being studied. The objectives of the research were to compare the effectiveness of antibiotics regimen with and without lansoprazole in reducing the level of the severity and quality of life improvement in LPR patients with H. pylori infection. Twenty six subjects were divided into two groups; the first group received antibiotics with lansoprazole and the second group received antibiotics without lansoprazole. The research subjects were assessed using reflux symptom index (RSI) questionnaire and reflux finding score (RFS) while the assessment on the quality of life was performed using reflux qual short-form (RQS) questionnaire. These data were obtained at baseline and after 2 weeks of treatment. The method was randomized clinical trial with open label observation and the analysis was conducted using t and Mann Whitney tests. There was a significant improvement in the RSI post treatment in the first group (p=0.034). The difference in RFS was not significantly different statistically between both groups (p=0.169). The RQS was significantly better statistically in the first group (p=0.018). It is concluded that treatment regimen with claritromicin, amoxycillin and lansoprazole is more effective in the treatment of LPR associated with H. pylori infection compared to without lansoprazole. [MKB. 2012;44(4):224-32].

show abstract

“…2 Prevalensi RLF sebesar 15-20% dan >15% penderita tersebut berobat ke dokter spesialis THT dengan manifestasi keluhan RLF yang berdampak menurunnya kualitas hidup. 3 Telah banyak penelitian dilakukan untuk membuktikan manifestasi ekstraesofageal GERD. Pepsin yang terdapat dalam cairan lambung, terdeteksi di dalam sekret paru, jaringan laring dan sinus, sputum, serta efusi telinga tengah.…”

unclassified

Perbandingan Efektivitas antara Omeprazol dan Lansoprazol terhadap Perbaikan Kualitas Hidup Penderita Rinosinusitis Kronik Akibat Refluks Laringofaring

Kurniawati¹,

Madiadipoera²,

Sarbini³

et al. 2012

mkb

View full text Add to dashboard Cite

AbstrakRefluks laringofaring (RLF) adalah refluks cairan lambung melalui esofagus ke daerah laringofaring. Prevalensi RLF 15-20%, dan menjadi salah satu penyebab rinosinusitis kronik. Insidensi RLF pada penderita rinosinusitis kronik sebesar 37-72%. Prevalensi rinosinusitis kronik 16,3% pada dewasa dan berefek terhadap kualitas hidup. Omeprazol dan lansoprazol adalah proton pump inhibitor (PPI), digunakan sebagai terapi RLF, juga digunakan pada rinosinusitis kronik akibat RLF. Effectiveness Comparison between Omeprazole and Lansoprazole on the Improvement of Quality of Life in Patients with Chronic RhinosinusitisCaused by Laryngopharyngeal Reflux AbstractLaryngopharyngeal reflux (LPR) is the reflux of gastric acid through the esophagus that reaches laringopharyngeal area. The prevalence of LPR in the range 15-20%, and caused chronic rhinosinusitis (CRS). The incidence of LPR in patients with CRS has ranged between 37-72%. The prevalence of CRS 16,3% in adults and affecting quality of life. Omeprazole and lansoprazole are proton pump inhibitors (PPIs) for LPR's therapy and also a therapy for CRS with LPR as the etiology. This research method was randomized clinical trial with open trial observation, conducted in June to December 2009. Twenty subjects with consecutive sampling method, divided into two groups (with simple randomization), the first group received omeprazole and the other lansoprazole. The subjects conducted complete physical otolaryngology examination, sino-nasal outcome test 20, reflux symptom index and reflux finding score with fiber optic rhinolaryngoscopy. These data was obtained before therapy, after 2 weeks and two months therapy, analyzed with Wilcoxon's and Mann-Whitney's test. There was no effectivity difference between omperazole and lansoprazole in reducing the level of severity of LPR (p>0.05), but quality of life improvement was better in lansoprazole than omeprazole group (p<0.05). In conclusion, lansoprazole is more effective than omeprazole in improvement of quality of life in patients with chronic rhinosinusitis caused by LPR. [MKB. 2012;44(3):138-46].

show abstract

Correlation between Symptoms and Laryngeal Signs in Laryngopharyngeal Reflux

Abstract: There appears to be poor correlation between signs and symptoms of LPR, particularly when monitoring therapeutic outcomes. In patients unresponsive to twice-daily proton-pump inhibitor therapy for 4 months, further aggressive therapy is unlikely to bring additional symptomatic benefit.

Cited by 100 publications

References 24 publications

Concordance between Symptoms Reported By Patients and Signs Elicited By Orthopedic Surgeons

Concordance between Symptoms Reported By Patients and Signs Elicited By Orthopedic Surgeons

Efektivitas Pemberian Antibiotik Disertai Lansoprazol pada Refluks Laringofaring dengan Infeksi Helicobacter pylori

Perbandingan Efektivitas antara Omeprazol dan Lansoprazol terhadap Perbaikan Kualitas Hidup Penderita Rinosinusitis Kronik Akibat Refluks Laringofaring

Contact Info

Product

Resources

About