Correlation between surface properties and wettability of multi-scale structured biocompatible surfaces

Gorodzha, Svetlana Nikolaevna; Surmeneva, Maria A.; Prymak, Oleg; Wittmar, Alexandra; Ulbricht, Mathias; Epple, Matthias; Тересов, А. Д.; Koval, N. N.; Surmenev, Roman A.

doi:10.1088/1757-899x/98/1/012026

Cited by 3 publications

(9 citation statements)

References 11 publications

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“…An important objective was to define electrospinning parameters to prepare scaffolds with different fiber sizes. It is known that rotation speed of the collector in the range of 200–800 rpm allows fabrication of randomly oriented electrospun PCL microfibres 16 . The average interconnected pore size of the prepared fibrous mesh is ∼10–50 μm, which is composed of randomly oriented microfibres with diameters ranging from several to 10 μm 17,36 .…”

Section: Resultsmentioning

confidence: 99%

“…The polymer solution (10 ml) was delivered at a constant flow rate of 2 ml·h −1 . The electrospinning time was set at 3 h. A cylindrical stainless steel collector rotating with a speed ranging from 200 to 1100 rpm was used to vary the fiber diameter of the prepared scaffolds, as reported in detail elsewhere 16 . The fixation of the syringe was made in the horizontal plane of the infusion pump.…”

Section: Methodsmentioning

confidence: 99%

“…A Bruker Equinox 55 Fourier transform infrared (FTIR) spectrometer (Saarbrücken, Germany) was used to reveal the molecular composition of the scaffolds 16 . The spectra were obtained within the wavelength range 4000–400 cm −1 by carrying out 100 scan iterations with further averaging.…”

Section: Methodsmentioning

confidence: 99%

“…This technique allows fabrication of fibers with diameters from several nanometers to several micrometers or even more 15 . During electrospinning, an electric field is applied to convert polymer solution into the form of nano‐ or microfibres 16 …”

Section: Introductionmentioning

confidence: 99%

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The effect of different sizes of cross‐linked fibers of biodegradable electrospun poly(ε‐caprolactone) scaffolds on osteogenic behavior in a rat model in vivo

Surmenev

Иванов

Saveleva

et al. 2022

J of Applied Polymer Sci

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A variety of biodegradable polymer scaffolds serving the purpose of mimicking the extracellular matrix have been studied; however, no effective recipe has yet been developed for scaffold pore size and overall percent porosity, which are optimal for cell penetration in vitro and tissue growth in vivo. Thus, this study reports the effect of poly(ε-caprolactone) (PCL) fiber size and scaffold porosity on the osteogenic behavior of scaffolds in a rat model in vivo. It was revealed that scaffolds with an average fiber size of 9.2 μm, and 4.05 μm, and combination of 0.6 μm submicrofibres (upper layer) with 9.2 μm microfibres (bottom layer) in hybrid two-layer scaffolds behave significantly differently with respect to macrophage reactions and tissue regeneration in a rat model in vivo. Poor macrophage response at implantation tests into the bone tissue in vivo reveals the advantages of microfibrous PCL scaffolds with a fiber size of 4.05 μm and hybrid scaffolds with submicro-and microfibres for stimulation of reparative osteogenesis over microfibrous scaffolds with a fiber size of 9.2 μm. The combination of submicro-and microfibrous layers in hybrid scaffolds provides an opportunity to control the shape and density of bone trabeculae during regeneration processes in vivo.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of different sizes of cross‐linked fibers of biodegradable electrospun poly(ε‐caprolactone) scaffolds on osteogenic behavior in a rat model in vivo

Surmenev

Иванов

Saveleva

et al. 2022

J of Applied Polymer Sci

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“…We have performed a 3D orientation analysis of microfibrous scaffolds made from biodegradable PCL polymer with aligned and randomly oriented fiber structure using the presented method. Such scaffolds are widely applied in regeneration medicine as they serve as constructions which imitate an extracellular matrix of native bone tissue [ 62 ].…”

Section: Applicationmentioning

confidence: 99%

GPU-accelerated ray-casting for 3D fiber orientation analysis

et al. 2020

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Orientation analysis of fibers is widely applied in the fields of medical, material and life sciences. The orientation information allows predicting properties and behavior of materials to validate and guide a fabrication process of materials with controlled fiber orientation. Meanwhile, development of detector systems for high-resolution non-invasive 3D imaging techniques led to a significant increase in the amount of generated data per a sample up to dozens of gigabytes. Though plenty of 3D orientation estimation algorithms were developed in recent years, neither of them can process large datasets in a reasonable amount of time. This fact complicates the further analysis and makes impossible fast feedback to adjust fabrication parameters. In this work, we present a new method for quantifying the 3D orientation of fibers. The GPU implementation of the proposed method surpasses another popular method for 3D orientation analysis regarding accuracy and speed. The validation of both methods was performed on a synthetic dataset with varying parameters of fibers. Moreover, the proposed method was applied to perform orientation analysis of scaffolds with different fibrous micro-architecture studied with the synchrotron μCT imaging setup. Each acquired dataset of size 600x600x450 voxels was analyzed in less 2 minutes using standard PC equipped with a single GPU.

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Exploring the Depths of Corrosion: A Novel GE-XANES Technique for Investigating Compositionally Complex Alloys

et al. 2023

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In this study, we propose the use of nondestructive, depth-resolved, element-specific characterization using grazing exit X-ray absorption near-edge structure spectroscopy (GE-XANES) to investigate the corrosion process in compositionally complex alloys (CCAs). By combining grazing exit X-ray fluorescence spectroscopy (GE-XRF) geometry and a pnCCD detector, we provide a scanning-free, nondestructive, depth-resolved analysis in a sub-micrometer depth range, which is especially relevant for layered materials, such as corroded CCAs. Our setup allows for spatial and energy-resolved measurements and directly extracts the desired fluorescence line, free from scattering events and other overlapping lines. We demonstrate the potential of our approach on a compositionally complex CrCoNi alloy and a layered reference sample with known composition and specific layer thickness. Our findings indicate that this new GE-XANES approach has exciting opportunities for studying surface catalysis and corrosion processes in real-world materials.

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Correlation between surface properties and wettability of multi-scale structured biocompatible surfaces

Cited by 3 publications

References 11 publications

The effect of different sizes of cross‐linked fibers of biodegradable electrospun poly(ε‐caprolactone) scaffolds on osteogenic behavior in a rat model in vivo

The effect of different sizes of cross‐linked fibers of biodegradable electrospun poly(ε‐caprolactone) scaffolds on osteogenic behavior in a rat model in vivo

GPU-accelerated ray-casting for 3D fiber orientation analysis

Exploring the Depths of Corrosion: A Novel GE-XANES Technique for Investigating Compositionally Complex Alloys

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