Correlation Between Single Nucleotide Polymorphisms in Cxcr4 Microrna Binding Site and the Susceptibility to Knee Osteoarthritis in Han Chinese Population

Abstract

Background:This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) at the microRNA target sequence in CXCR4 and the susceptibility to knee osteoarthritis (KOA).Methods:A total of 305 patients with KOA and 305 healthy controls were recruited into this study. The genotypes of CXCR4 rs1804029 and rs17848060 loci were analyzed.Results:The susceptibility to KOA of CXCR4 rs1804029 G allele carriers was 1.33 times that of T allele carriers. The KOA susceptibility in individuals carrying T allele at CXCR4 rs17848060 locus was 1.38 times that of individuals carrying A allele (95% CI: 1.17-1.57, p < 0.001). The G allele at CXCR4 rs1804029 locus was the target of hsa-miR-146a-3p, while the A allele at CXCR4 rs17848060 locus could be targeted by hsa-miR-20a-3p. The plasma level of hsa-miR-146a-3p was lower in rs1804029 G allele carriers than T allele carriers, whereas plasma level of hsa-miR-20a-3p was higher in rs17848060 T allele carriers than A allele carriers.Conclusion:The SNPs at rs1804029 and rs17848060 loci in CXCR4 were significantly associated with the susceptibility to KOA in Han Chinese population.