Correlation between sex hormone levels and obesity in the elderly male

Cao, Jian; Chen, Tian-Meng; Hao, Weijun; Li, Jian; Liu, Lin; Zhu, Bin; Li, Xiaoying

doi:10.3109/13685538.2012.666585

Cited by 26 publications

(19 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, total and free T were inversely associated with body mass index (BMI), but not related to age [109]. Moreover, in elderly Asian men the levels of total T in the obesity group were significantly lower than those in non-obese subjects and BMI was negatively correlated with total T [110]. In summary, the data show a strong correlation between obesity and low total and free T levels.…”

mentioning

confidence: 69%

Neuronal basis of reproductive dysfunctions associated with diet and alcohol: From the womb to adulthood

Gawałek

Śliwowska

2015

Reproductive Biology

View full text Add to dashboard Cite

mentioning

confidence: 69%

Neuronal basis of reproductive dysfunctions associated with diet and alcohol: From the womb to adulthood

Gawałek

Śliwowska

2015

Reproductive Biology

View full text Add to dashboard Cite

“…17–21 In community-based studies, obesity and metabolic syndrome are associated with adverse atrial electrical remodeling, prospective development of AF, 22–24 and inversely related to testosterone in older men. 25, 26 Diabetes, hypertension, and smoking constitute additional, established risk factors for AF that also have been associated with reduced endogenous sex hormones in men. 17, 27, 28 …”

Section: Discussionmentioning

confidence: 99%

Association of Sex Hormones, Aging, and Atrial Fibrillation in Men

Magnani

Moser

Murabito

et al. 2014

Circ: Arrhythmia and Electrophysiology

View full text Add to dashboard Cite

Background Endogenous sex hormones have been related to cardiovascular outcomes and mortality. We hypothesized that sex hormones are related to atrial fibrillation (AF) in a community-based cohort of middle-aged to older men. Methods and Results We examined testosterone, estradiol, and dehydroepiandrosterone sulfate [DHEA-S]) in relation to incident AF in men participating in the Framingham Heart Study. We assessed the 10-year risk of AF in multivariable-adjusted hazard models. The cohort consisted of 1251 men (age 68.0±8.2), of whom 275 developed incident AF. We identified a significant interaction between age and testosterone, and therefore stratified men into age 55–69 (n=786), 70–79 (n=351), and ≥80 (n=114). In men 55–69 each 1-standard deviation (SD) decrease in testosterone was associated with hazard ratio (HR) 1.30 (95% confidence interval [CI], 1.07 to 1.59) for incident AF. The association between testosterone and 10-year incident AF in men 70–79 did not reach statistical significance. In men ≥80 years a 1-SD decrease in testosterone was associated with HR 3.53 (95% CI, 1.96 to 6.37) for AF risk. Estradiol was associated with incident AF (HR, 1.12; 95% CI, 1.01 to 1.26). DHEA-S had a borderline association with risk of AF that was not statistically significant (HR, 1.12; 95% CI, 0.99 to 1.28). Conclusions Testosterone and estradiol are associated with incident AF in a cohort of older men. Testosterone deficiency in men ≥80 is strongly associated with AF risk. The clinical and electrophysiologic mechanisms underlying the associations between sex hormones and AF in older men merit continued investigation.

show abstract

“…This was an unexpected result; however, it may be explained by the fact that this was a trend and as such not statistically significant. Alternatively, it is possible that because the promoter that induces the TRAMP oncogene is testosterone driven these mice require a specific period of time to progress from well differentiated to poorly differentiated tumors and that the obese mice have lower levels of testosterone such as has been found in obese human males [49, 50] thereby reducing the number of poorly differentiated tumors in the animals.…”

Section: Discussionmentioning

confidence: 99%

Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity

et al. 2012

View full text Add to dashboard Cite

To clarify effects of diet and body weight on prostate cancer development, three studies were undertaken using the TRAMP mouse model of this disease. In the first experiment, obesity was induced by injection of gold thioglucose (GTG). Age of prostate tumor detection (~33 wk) and death (~43 wk) was not significantly different among the groups. In the second study, TRAMP-C2 cells were injected into syngeneic C57BL6 mice and tumor progression was evaluated in mice fed either high-fat or low-fat diets. The high fat fed mice had larger tumors than did the low-fat fed mice. In the third study, tumor development was followed in TRAMP mice fed a high fat diet from 6 weeks of age. There were no significant effects of body weight status or diet on tumor development among the groups. When the tumors were examined for the neuroendocrine marker synaptophysin, there was no correlation with either body weight or diet. However, there was a significant correlation of the expression of synaptophysin with earlier age to tumor detection and death. In summary, TRAMP-C2 cells grew faster when the mice were fed a high-fat diet. Further synaptophysin may be a marker of poor prognosis independent of weight and diet.

show abstract

Correlation between sex hormone levels and obesity in the elderly male

Cited by 26 publications

References 27 publications

Neuronal basis of reproductive dysfunctions associated with diet and alcohol: From the womb to adulthood

Neuronal basis of reproductive dysfunctions associated with diet and alcohol: From the womb to adulthood

Association of Sex Hormones, Aging, and Atrial Fibrillation in Men

Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity

Contact Info

Product

Resources

About