Correlation between severity of thyroid dysfunction and renal function

Hollander, Jan G. den; Wulkan, R. W.; Mantel, Mart J; Berghout, A

doi:10.1111/j.1365-2265.2005.02236.x

Cited by 220 publications

(190 citation statements)

References 18 publications

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“…Therefore, this shows that the effect of low thyroid function on creatinine metabolism in muscle and the resultant changes of serum and urinary creatinine levels are not responsible for low GFR in patients with low normal thyroid function. Causality is not conclusively determined, but it is likely that low thyroid function may reduce GFR, RPF, and RBF by increasing R a , as it has been shown that T 4 replacement therapy increases GFR in hypothyroid patients (20) and that treatment of Graves' patients with anti-thyroid drugs decreases GFR (21). Our study may also be consistent with the results that TSH positively correlated with creatinine in hypothyroid subjects (22).…”

Section: Discussionsupporting

confidence: 82%

Relationship between serum TSH levels and intrarenal hemodynamic parameters in euthyroid subjects

Tsuda

Inaba

Ichii

et al. 2013

European Journal of Endocrinology

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Objective: Low thyroid function may be associated with a reduced glomerular filtration rate (GFR) calculated on the basis of creatinine metabolism. Thyroid hormone directly affects serum creatinine in muscle and low thyroid function might exert a similar direct effect in the kidney. The goal of the study was to evaluate this possibility by assessment of the inulin-based GFR and to examine the mechanism underlying the reduction of GFR. Patients and methods: Renal and glomerular hemodynamics were assessed by simultaneous measurements of plasma clearance of para-aminohippurate (C PAH ) and inulin (C in ) in 26 patients with serum creatinine !1.00 mg/dl and without thyroid disease. All subjects were normotensive with or without antihypertensive treatment and were kept in a sodium-replete state. Renal and glomerular hemodynamics were calculated using Gomez's formulae. Results: Serum TSH, including within the normal range (0.69-4.30 mIU/ml), was positively correlated with vascular resistance at the afferent arteriole (R a ) (rZ0.609, PZ0.0010), but not at the efferent arteriole (R e ). Serum TSH was significantly and negatively correlated with renal plasma flow (RPF), renal blood flow (RBF), and GFR (rZK0.456, PZ0.0192; rZK0.438, PZ0.0252; rZK0.505, PZ0.0086 respectively). In multiple regression analysis, serum TSH was significantly positively associated with R a after adjustment for age and mean blood pressure. Conclusions: These findings suggest that low thyroid function, even within the normal range, is associated with reduced RPF, RBF, and GFR, which might be caused by a preferential increase in R a .

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Section: Discussionsupporting

confidence: 82%

Relationship between serum TSH levels and intrarenal hemodynamic parameters in euthyroid subjects

Tsuda

Inaba

Ichii

et al. 2013

European Journal of Endocrinology

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“…In corroboration with our findings, T 3 was reported to have beneficial effects on renal function in a diabetic patient with end-stage renal failure and severe hypothyroidism (van Welsem & Lobatto 2007). Renal function was improved by T 3 in 32 patients with hypothyroidism (den Hollander et al 2005). Therefore, treatments with thyroid hormone may be an effective therapeutic approach for delaying progressive renal damage or even renal failure in diabetic patients with hypothyroidism or subclinical hypothyroidism.…”

Section: Discussionsupporting

confidence: 75%

Thyroid hormone ameliorates diabetic nephropathy in a mouse model of type II diabetes

Yan

Sun

2011

Journal of Endocrinology

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Conventional therapies for diabetic patients, such as strict glycemic control, do not completely stop the progression of diabetic nephropathy. Serum-free tri-iodothyronine (T 3 ) levels were lower in patients with type II diabetes. The purpose of this study was to test a hypothesis that treatment with T 3 would improve diabetic nephropathy in db/db mice, a model of type II diabetes. Male db/db mice (16 weeks) were treated with T 3 for 4 weeks. Urinary excretions of albumin and blood glucose levels were measured. Kidneys were collected for histological examination and molecular assays of transforming growth factor-b1 (TGF-b1) expression and phosphatidylinositol 3-kinase (PI3K). T 3 attenuated albuminuria in db/db mice, suggesting an improved kidney function. T 3 significantly decreased accumulation of collagenous components in cortical interstitium (interstitial fibrosis) and expansion of mesangial matrix in glomeruli (glomerulosclerosis) and prevented the loss of glomeruli in db/db mice. Therefore, T 3 improved the renal structural damage seen in diabetic mice. Notably, diabetic nephropathy was accompanied by a significant decrease in PI3K activity and an increase in TGF-b1 expression in kidneys. T 3 restored renal PI3K activity, attenuated hyperglycemia, and decreased renal TGF-b1 expression in db/db mice. These effects of T 3 were abolished by simultaneous treatment with PI3K inhibitor (LY294002). These data suggest that T 3 prevented progressive kidney damage and remodeling in db/db mice by improving insulin signaling (e.g. PI3K activity).

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“…The changes in biochemical markers of renal function were found to be reversible after thyroxine replacement therapy in the 46 patients who were administered thyroxine replacement. Similar changes in serum creatinine with hypothyroidism and improvement with treatment have been reported in a few scattered studies and case reports (10)(11)(12)(13). In the present study, a decrease in serum creatinine was observed in 95.65% and a decrease in uric acid was observed in 91.30% of paired values before and after treatment for hypothyroidism.…”

Section: Discussionsupporting

confidence: 56%

Biochemical markers of liver and kidney function are influenced by thyroid function-a case-controlled follow up study in Indian hypothyroid subjects

Arora

Chawla

Tayal

et al. 2009

Indian J Clin Biochem

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Correlation between severity of thyroid dysfunction and renal function

Abstract: The kidney is an important target of thyroid hormone action.

Cited by 220 publications

References 18 publications

Relationship between serum TSH levels and intrarenal hemodynamic parameters in euthyroid subjects

Relationship between serum TSH levels and intrarenal hemodynamic parameters in euthyroid subjects

Thyroid hormone ameliorates diabetic nephropathy in a mouse model of type II diabetes

Biochemical markers of liver and kidney function are influenced by thyroid function-a case-controlled follow up study in Indian hypothyroid subjects

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