Correlation between severity of obesity and mortality in cardiogenic shock

Delfiner, Matthew S.; Romero, Carlos Manuel; Dillane, Catherine; Feldman, Elizabeth; Hamad, Abdullah

doi:10.1016/j.hrtlng.2022.08.022

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Upon restoration of blood pressure, through alternating vasoconstriction and vasodilation along with changes in vascular permeability to ischemic areas, an inflammation-like reaction termed reperfusion injury will occur, which leads to the activation of inflammatory mediators, such as interleukin-6 (IL-6), leukocytes, and tumor necrosis factor alpha (TNF-alpha), which will cause pathological vasodilation [6]. This vasodilation contributes to the mortality associated with CS as it propagates the sequence of events described above and creates a regressing cycle of the body constantly attempting to compensate for heightened requirements of function [1][2][3][4]. Vasodilation will also release nitric oxide synthase and peroxynitrite, which have cardiotoxic contractility effects.…”

Section: Pathophysiologymentioning

confidence: 99%

“…A probable cause of this increase in incidence on admission is the improvement in healthcare networks, which has allowed effective transportation of patients within 90 minutes to hospitals equipped with a catheterization lab where percutaneous coronary intervention (PCI) can be performed [3]. As obesity, diabetes, and other diseases increase cardiovascular disease incidences, it is more paramount than ever to understand the development of CS so that it can be detected sooner [4][5]. Earlier interventions, such as metabolic screenings for biological markers and radiological imaging, can help spot several developing diseases, such as cardiomyopathy and valvular heart disease, which could be addressed prior to the development of CS [6].…”

Section: Introductionmentioning

confidence: 99%

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Advanced Metrics and Early Predictors of Cardiogenic Shock

Shah,

Orta,

Daryanani

et al. 2023

Cureus

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Cardiogenic shock (CS) can be defined as a range of illnesses that describes a state where cardiac output, which is the blood volume ejected from the left ventricle every minute that leads to tissue perfusion of nutrients, is insufficient in providing adequate oxygenation to the systemic circulation. The incidence of CS on admission has increased in recent years, with the six-and 12-month mortality rates remaining unchanged. The purpose of this literature review is to bring forth several parameters that have been utilized in the past 10 years to predict CS mortality. Further studies to implement these parameters in management algorithms, along with early screenings and advanced treatment options such as mechanical cardiac assist devices, can improve the mortality associated with CS. This literature-based review was conducted by evaluating current research focusing on the clinical presentation of CS and predictors of CS. PubMed served as the primary database for article retrieval due to access. Two searches were conducted: One for clinical presentations and advanced metrics for CS and another for early predictors for CS. Thirteen articles regarding clinical presentation and seven articles regarding early predictors were selected. Three tools/scores and five laboratory tests were identified that allowed clinicians to prognosticate outcomes in patients suffering from CS based on clinical and laboratory presentations. Examining these predictors will allow earlier intervention in the development of CS and potentially help lower the mortality rate of CS. The eventual creation of a scoring system that incorporates multiple metrics discussed in this review can provide the most accurate prognosis of CS, which can lead to more targeted interventions.

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