Correlation between Serum Squamous Cell Carcinoma Antigen Level and Tumor Volume in Head and Neck Cancer

Abstract

Purpose of Study: An association of squamous cell carcinoma antigen (SCC-Ag) level with cancer prognosis has been reported in many studies. Our investigators conducted the first study determining a correlation between the SCC-Ag level and the tumor volume in head and neck cancer. Procedures: The SCC-Ag level of patients were measured from the serum, whilst the tumor volume was calculated by the ellipsoid formula and verified by logistic software on radiology. The correlation between SCC-Ag level and tumor volume was analyzed. Results: Fifty-two patients were studied, with the mean age of 62.4 years. Tumor types were: oral cavity cancer (11 cases, 21.6%), oropharyngeal cancer (21 cases, 40.38%), hypopharyngeal cancer (8 cases, 15.7%), and laryngeal cancer (12 cases, 23.5%). Mean tumor volume was 20.01 mL (range 0.02–91.46 mL). Mean SCC-Ag level was 2.69 ng/mL (range 0.5–14.6 ng/mL). The critical point of SCC-Ag was 5.8 ng/mL. The Pearson’s correlation coefficient between SCC-Ag level and tumor volume was 0.524 (p = 0.0002). Conclusions: SCC-Ag moderately correlates with tumor volume in head and neck cancer patients, with statistical significance. We suggest that using tumor volume, rather than a one-dimensional measurement such as tumor size, to analyze correlation with SCC-Ag offers a more accurate means of cancer prognosis.

Preoperative squamous cell carcinoma antigen and albumin serum levels predict the survival of patients with stage T1-3N0M0 esophageal squamous cell carcinoma: a retrospective observational study

“…In this study, we observed that the SCC-Ag level adjusted for tumor staging was an independent prognostic factor for patients with ESCC, similar to the results of Shimada et al [15,25]. The most likely explanation was that the SCC-Ag level is mainly determined by tumor volume and internal potential for malignancy, such as expression of gene Wnt-11 [11,26], Fig. 4 Cancer-specific survival curve for the whole cohort of patients with ESCC according to the groups (Group A included low SCC-Ag and high albumin levels; Group B included patients with high SCC-Ag or low albumin levels; Group C included patients with low albumin and high SCC-Ag levels) Fig.…”

“…Previous studies suggested that serum squamous cell carcinoma antigen (SCC-Ag) levels had likely an effect on prognosis of malignant tumor [6][7][8][9], such as oral squamous cell carcinoma [7,10] and head and neck cancer [11,12]. Indeed, SCC-Ag is a widely used tumor marker in oncology.…”

Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma

“…The search for noninvasive tumor markers in cancer is a rapidly growing area of research (Chen et al, 2008). SCC-Ag is an existing molecular biomarker that is used for clinical cancer diagnoses in China, but it is not a tumor-specific biomarker ( Jantharapattana et al, 2018). Aberrations in miRNA expression levels might be linked to the onset and progression of various types of cancer (Ferlay et al, 2015).…”

Nanodetection of Head and Neck Cancer on Titanium Oxide Sensing Surface

“…Researchers have found that serum SCC-Ag was at a significant risk level for the cancers in the hypopharynx, oral cavity and larynx [8,9]. In addition, there was a correlation between SCC-Ag level and the tumour volume in head and neck cancer patients [10]. It is wise to quantify the level of SCC-Ag to identify the condition of head and neck cancer, in order to provide the earlier treatment.…”