Correlation between Serum Sodium and Potassium Levels and Risk of Developing Hypertension

Mane, Anil S

doi:10.21276/ijcmr.2018.5.11.15

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…Serum sodium and serum potassium levels were significantly associated with the risk of development of hypertension. [4] This study was carried out to determine whether Phyllantus amarus has an effect on serum electrolytes level which could result in an evident change in blood pressure. Also, to examine if there is any difference between the effects of Phyllantus amarus on a hypertensive subject compared to its effect on the electrolyte level of normotensive subjects.…”

Section: Discussionmentioning

confidence: 99%

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Comparative Effects of Phyllantus Amarus on the Serum Electrolyte Level of Hypertensive and Normotensive Male Wistar Rats

Osonuga,

Faderera,

Adejoke

et al. 2023

CCJ

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Highlights: It discusses effects of phyllantus amarus on serum electrolyte which results in an imbalance. The reducing effect oh sodium and chloride levels implicate a new chance in managing hypertension. Abstract: Background. High blood pressure, also known as hypertension, is one of the most well-known major risk factors for cardiovascular disease (CVD) and stroke. Aims. This present study tried to compare the effect of P.amarus leaves on normotensive and hypertensive male Wistar rats. Materials and method. 15 male Wistar rats were divided into three groups of five rats each (Control group, Control + Extract group, and Hypertensive+ Extract group). One of the groups of rats (group 3) was induced with hypertension using 0.5mg/kg for 5 days of Dexamethasone. Then, the normal/control group and the hypertensive were treated with 200mg/kg of aqueous Extract of Phyllantus amarus (AEPA) for 28 days. Fasting venous blood samples were collected for the measurements of serum electrolytes. Serum potassium, sodium, and chlorine levels were measured by the ion-selective electrode method. Results. In this experiment, for the normotensive and hypertensive treatment groups respectively, there was an increase in K⁺ level and decrease in K⁺ level compared to the control rats, decrease in Na⁺ level, and decrease in Na⁺ level. Also, a decrease in Clˉ of normotensive rats while there was no change in the Clˉ level of hypertensive group when compared to control group. The p values for all results were found to be non-significant. Phyllantus amarus has an effect on serum electrolyte imbalance. Its reducing effect on sodium and chloride levels implies that it can be used to manage hypertension, thereby reducing the risk of developing cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

“…Sodium, potassium, and chloride are the significant electrolytes along with magnesium, calcium, phosphate, and bicarbonates. Research done by Mane [4] , revealed that serum sodium levels and serum potassium were significantly associated with the risk of development of hypertension.…”

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Phyllantus Amarus on the Serum Electrolyte Level of Hypertensive and Normotensive Male Wistar Rats

Osonuga,

Faderera,

Adejoke

et al. 2023

CCJ

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“…Well controlled and monitored blood pressure can prevent decrease in glomerular filtration rate in diabetic and non-diabetic patients (23,24). However, some of these studies indicate in addition to blood pressure, proteinuria should be under tight control for prevention from renal and cardiovascular protection (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Nephrin a biomarker of early glomerular injury in newly diagnosed untreated hypertensive subjects

et al. 2022

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Introduction and Aim: Hypertension and proteinuria is known to cause renal and cardiovascular disease and mortality in patients irrespective of diabetes. It is beneficial to identify proteinuria and probable glomerular injury early to take preventive measures from cardiovascular event. In our study, we aimed to evaluate whether a biomarker such as nephrin can detect early glomerular injury in treatment naïve hypertensive subjects. Materials and Methods: Forty newly diagnosed, treatment naïve hypertensive subjects were recruited for the study along with 40 normotensive controls after obtaining informed consent and procuring approval from. Institutional Ethics Committee. The hypertensive group was classified as diabetic and non-diabetic hypertensives and compared with apparently healthy controls (normotensive). Urine sample was analyzed for microalbumin, creatinine and nephrin. Blood sample was analyzed for glycated hemoglobin, urea, creatinine, sodium, and potassium. Statistical analysis was performed using ANOVA to compare the groups for various parameters. Odds ratio was calculated. Results: Hypertensives were sub-grouped based on amount of microalbumin excreted. Urine nephrin excretion was significantly higher in hypertensive subjects than normotensive subjects (nephrin cut-off: 0.09 mg/g of creatinine). Urine nephrin (mg/g) was found to be elevated (median 0.15; interquartile range, 0.12 and 0.17) in hypertensives with normoalbuminuria and it was significantly higher than normotensive subjects (median 0.07; interquartile range, 0.04 and 0.09). Conclusion: Urine nephrin may be used as a biomarker of early glomerular injury in hypertensive subjects even before microalbuminuria is detected.

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Correlation between Serum Sodium and Potassium Levels and Risk of Developing Hypertension

Cited by 2 publications

References 24 publications

Comparative Effects of Phyllantus Amarus on the Serum Electrolyte Level of Hypertensive and Normotensive Male Wistar Rats

Comparative Effects of Phyllantus Amarus on the Serum Electrolyte Level of Hypertensive and Normotensive Male Wistar Rats

Nephrin a biomarker of early glomerular injury in newly diagnosed untreated hypertensive subjects

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