Correlation Between Serum Selenium Level and Febrile Seizures

Mahyar, Abolfazl; Ayazi, Parviz; Fallahi, Mazdak; Javadi, Amir

doi:10.1016/j.pediatrneurol.2010.05.024

Cited by 32 publications

(27 citation statements)

References 36 publications

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“…And these results was agreed by Similar studies which done by Mahyar et al, 2010 and Amiri et al, 2010 [34,35]. In both studies the serum selenium level in the children who had febrile convulsion was significantly lower than controls (P<0.0001).…”

Section: Discussionsupporting

confidence: 89%

Assessment of the Level of GABA and Some Trace Elements in Blood in Children who Suffer from Familial Febrile Convulsions

Salah¹,

Abdelraouf²,

Abdelhameed³

et al. 2014

Open Access Maced J Med Sci

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Febrile seizure is one of the most common neurological problems during childhood. The etiology and pathogenesis of febrile seizure remain unknown. However, several factors such as vitamin B6 deficiency, electrolyte disturbances, and reduction in serum zinc, selenium, magnesium levels, and low gamma -aminobutyric acid (GABA) levels are thought to play a role in the pathogenesis of febrile seizure. The present study included twenty children from 10 families, 11 were male and 9 were female. Each family has at least 2 members with a history of febrile convulsion. All cases were subjected to the following: Determination of serum levels of copper, zinc, magnesium, selenium level in serum, and plasma level of γ-aminobytaric acid (GABA). Serum levels of selenium and GABA were statistically significantly low in comparison with controls. Serum copper was statistically significantly higher in cases than controls, while serum zinc showed no significant changes in the cases of febrile convulsion compared with the control group. The mean Zn level in the serum of febrile convulsion was found to be at lower level than in the control group. The serum magnesium was significantly low in cases than controls. The logistic regression model in our study shows that Selenium and Magnesium have protective effects, while Copper has causative effect.

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Section: Discussionsupporting

confidence: 89%

Assessment of the Level of GABA and Some Trace Elements in Blood in Children who Suffer from Familial Febrile Convulsions

Salah¹,

Abdelraouf²,

Abdelhameed³

et al. 2014

Open Access Maced J Med Sci

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“…In the current study, serum selenium levels in cases was significantly lower as compared with the controls (p value: 0.003), which is similar to studies done by Salah ON et al, Amiri et al and Mahyar et al [3][4][5] In a metaanalysis by Saghazade A et al, it was found that in children with febrile seizures there was no significant difference in serum selenium levels when compared to children with febrile illness without seizures. 6 In this study, serum selenium levels with respect to age, gender, weight and height, there was no statistically significant difference which is similar to the study conducted by Khoshdel A et al 8 Serum selenium levels in our study showed no statistically significant difference with regards degree of fever or duration of febrile seizure.…”

Section: Discussionsupporting

confidence: 90%

“…3 Many studies have shown an association between low serum selenium levels and febrile seizures equally. [3][4][5] Some studies have shown no association. 6 Hence our study is an attempt to evaluate the association between the serum selenium level and febrile seizures.…”

Section: Introductionmentioning

confidence: 99%

Association between serum selenium levels and febrile seizures in Indian children: a case control study

Khadria

Jaidev

Vidya

2017

Int J Contemp Pediatr

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Background: Febrile seizures are the most common form of childhood seizures. Children are at particular risk for selenium deficiency. There was various hypothesis about the co-relation between selenium levels and febrile seizures. The aim of the present study was to determine whether there were any changes in serum selenium levels in children with febrile seizures when compared to children with febrile illness without seizures.Methods: This was a hospital based prospective case control study, consisting of 40 children (20 cases and 20 controls) aged between 6 months to 60 months. The serum selenium level was measured in each of them by atomic absorption spectrophotometer. Data was analysed by using frequency percentage and pearson’s chi square test.Results: Out of the 40 children included in the study, serum selenium level was lower in febrile seizure group (80%) when compared to controls (20%) which was statistically significant (P value: 0.003). Also, there was no statistically significant difference between males and females.Conclusions: In the present study, we found significantly low serum selenium levels in children with febrile seizures as compared to the children with febrile illness with no seizures. Decreased levels of selenium in children with febrile seizures may be the result of oxidative damage, occurring in the neuronal cells. In our study, a significant co-relation between low levels of selenium and febrile seizures have been observed in children. However, since the numbers are small, further studies with larger sample size are recommended.

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“…The result of present study also showed that family history of FS, consanguinity and attendance at day care are factors that increase risk for FS 7.52, 13.10, 19.35 times, respectively. Although Mahyar et al reported similar to us prematurity is not a risk factor [17]. Vestrgaard and Christensen revealed that children born prematurely had an increased risk of FSs compared with children born at term, and the adjusted RR was 1.4 [18].…”

Section: Discussionmentioning

confidence: 66%