Correlation between serum prealbumin and prognosis of patients with hepatocellular carcinoma after hepatectomy

Jia, Rongrong; Zhong, Jian‐Hong; Huo, Rong‐Rui; Su, Qibin; Xiang, Xiao; Zhao, Fu‐Lin; Qin, Zhong‐Bian; Chen, Jiahao; Liao, Ying‐Yang; Ma, Liang; Xiang, Bang‐De; Zhang, Chunyan; Li, Le‐Qun

doi:10.1002/jso.25378

Cited by 24 publications

(21 citation statements)

References 19 publications

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“…We found that preoperative serum prealbumin level may be a useful marker for predicting long-term overall and disease-free survival, in the presence or absence of liver cirrhosis. These findings are consistent with previous studies 27, 28. A previous study used a cut-off value of 170 mg/L for preoperative prealbumin level compared to 200 mg/L in the present study.…”

Section: Discussionsupporting

confidence: 94%

“…They found only 29% (437/1483) patients with reduced prealbumin level, lower than the 51.9% (700/1349) in the present study 28. Our previous small study used a cut-off value of 182 mg/L for preoperative prealbumin level 27. Other studies found that prealbumin level lower than 170 mg/L is an independent risk factor for hepatic insufficiency after hepatic resection 26, 29.…”

Section: Discussioncontrasting

confidence: 57%

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Serum Prealbumin is Negatively Associated with Survival in Hepatocellular Carcinoma Patients after Hepatic Resection

Liao¹,

Peng²,

Jia³

et al. 2019

J. Cancer

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Objective: Low serum prealbumin levels are associated with poor prognoses in some type of cancers. However, the role of prealbumin in patients with hepatocellular carcinoma (HCC) is unknown. The present study aimed to investigate the role of serum prealbumin levels in long-term survival for HCC patients after hepatic resection. Methods: HCC patients who underwent hepatic resection from June 2007 to December 2015 were retrospectively analyzed in a tertiary liver center. Patients were classified as having normal or reduced serum prealbumin based on a cut-off value of 200 mg/L. Overall survival and recurrence rate were analyzed between groups. Propensity score analysis was used to reduce bias due to other patient differences at baseline. Results: A total of 1349 HCC patients who underwent hepatic resection were enrolled on this study, including 1168 (86.6%) male and 181 (13.4%) female. Patients with normal serum prealbumin had significantly higher overall survival than those with reduced serum prealbumin (P < 0.001). Similar findings were observed after propensity analysis and subgroup analysis based on liver cirrhosis. Moreover, patients with normal serum prealbumin had a significantly lower recurrence rate than those with reduced serum prealbumin (P < 0.001). Conclusions: Low preoperative level of serum prealbumin is associated with poor long-term survival in patients with HCC after hepatic resection. Low serum prealbumin may be a marker to identify patients at high risk of poor prognosis after hepatic resection.

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Section: Discussionsupporting

confidence: 94%

Section: Discussioncontrasting

confidence: 57%

Serum Prealbumin is Negatively Associated with Survival in Hepatocellular Carcinoma Patients after Hepatic Resection

Liao¹,

Peng²,

Jia³

et al. 2019

J. Cancer

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“…Notably, serum prealbumin, a plasma protein synthesized by hepatocytes, is an indicator of nutritional status in cancer patients. The present study demonstrated a linear dose-response relationship between serum prealbumin levels and the prognosis of HCC after hepatectomy, suggesting that higher levels of prealbumin may reduce the risk of death in HCC patients [20]. Altogether, the extent of tumor involvement, as reflected by these factors, heavily determines the risk of death.…”

Section: Discussionsupporting

confidence: 56%

Development and validation of a nomogram for assessing survival in patients with hepatocellular carcinoma after hepatectomy

et al. 2020

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Background and aim: Assessing the average survival rate of patients with hepatocellular carcinoma (HCC) after hepatectomy is important for making critical decisions in everyday clinical practice. The present study aims to develop and validate a nomogram for assessing the overall survival probability for such patients. Methods: The putative prognostic indicators for constructing the nomogram were identified using multivariable Cox regression and model selection based on the Akaike information criterion. The nomogram was subjected to internal and external validation. The nomogram endpoints were death within 1, 3, and 5 years. Results: A consecutive sample of 522 HCC patients who underwent potentially curative hepatectomy was retrospectively analyzed. Age, Barcelona clinic liver cancer (BCLC) stage, tumor size, alanine transaminase, alpha fetal protein, and serum prealbumin were included in the final model. The nomogram's discriminative ability was good in the training set (C-index was 0.74 for 1 year, 0.73 for 3 years, 0.70 for 5 years) and was validated using both an internal bootstrap method (C-index was 0.73 for 1 year, 0.72 for 3 years, 0.69 for 5 years) and an external validating set (C-index was 0.72 for 1 year, 0.72 for 3 years, 0.69 for 5 years). The calibration plots for the endpoints showed optimal agreement between the nomogram's assessment and actual observations. Conclusions: The nomogram (an Excel-based tool) can be useful for assessing the probability of survival at 1, 3, and 5 years in patients with HCC after hepatectomy.

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“…21 Furthermore, prealbumin has recently been identified as an independent prognostic factor in various cancers. 39,40 Based on this theoretical advantage, CRP/PAlb may be more sensitive and superior to CRP/Alb for tumor prognosis. In this study, we found that CRP/PAlb ratio was more useful for predicting the prognosis of patients with esophageal cancer compared with CRP/Alb ratio.…”

confidence: 99%

Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer

et al. 2020

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Background The prognostic value of combination of C-reactive protein and prealbumin (CRP/PAlb) in esophageal cancer remains unclear. Methods We enrolled 167 esophageal cancer patients who underwent curative esophagectomy. Univariate and multivariate analyses were performed to determine the prognostic significance of various markers, including CRP-to-albumin (CRP/Alb) ratio, modified Glasgow prognostic score, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index. Results Receiver operating characteristic analysis revealed the optimal cut-off value of each inflammatory factor, and CRP/PAlb ratio had the greatest discriminative power in predicting recurrence-free survival (RFS) among the examined measures (AUC 0.668). The 5-year overall survival and RFS rates were significantly lower in patients with high CRP/PAlb ratio than in those with low CRP/PAlb ratio (P < 0.001, P = 0.001, respectively). In the univariate analysis, RFS was significantly worse in patients with low BMI, T2 or deeper tumor invasion, positive lymph node metastasis, positive venous invasion, high CRP/PAlb ratio, high CRP/Alb ratio, high NLR, and high LMR. Multivariate analysis revealed that CRP/PAlb, but not CRP/Alb, was an independent prognostic factor along with lymph node metastasis. Conclusion CRP/PAlb ratio was useful for predicting the prognosis of esophageal cancer patients.

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Correlation between serum prealbumin and prognosis of patients with hepatocellular carcinoma after hepatectomy

Cited by 24 publications

References 19 publications

Serum Prealbumin is Negatively Associated with Survival in Hepatocellular Carcinoma Patients after Hepatic Resection

Serum Prealbumin is Negatively Associated with Survival in Hepatocellular Carcinoma Patients after Hepatic Resection

Development and validation of a nomogram for assessing survival in patients with hepatocellular carcinoma after hepatectomy

Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer

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