Correlation between serum myeloperoxidase with the severity of heart failure in children

Abstract

Heart failure in children is a global major health problem. Inflammation is an important role in pathophysiology of heart failure. Myeloperoxidase (MPO) included to the inflammation cascade. The objective was to analyze correlation between MPO with severity of heart failure in children. Observational analytic with cross sectional study was conducted on children aged 1 month-18 years with an acyanotic CHD with or without heart failure at Dr. Soetomo General Hospital Surabaya. Bivariate analysis used Mann Whitney test. Multivariate analysis used Kruskal Wallis. Correlation test used Spearman’s test with significance value was p<0.05. A total of 21 subjects, median age was 93 months old. The most common type of acyanotic CHD was VSD. Moderate heart failure was in 28% of subjects, 48% of subjects were mild heart failure. Median value of serum MPO levels in acyanotic CHD with heart failure was 36.25 (7.3-390) pg/ml. There was no differences in the value of serum MPO level in children with acyanotic CHD distinguished by the severity of heart failure (p=0.62). There was no correlation between serum MPO levels with the severity of heart failure in children (p=0.89). We concluded no correlation between serum MPO levels with the severity of heart failure in children.