Correlation Between Serum IGF-1 Levels and CVM Stages for the Assessment of Skeletal Maturity

Abstract

The major disadvantage in cervical vertebral maturation stages (CVMS) is the involvement of radiographic exposure. This study was undertaken to assess the applicability of insulin-like growth factor I (IGF-I) blood level as a maturation indicator by correlating it to the CVMS. METHODOLOGY: This cross-sectional study was conducted at orthodontic department of our institute. With 80% power of study, 5% desired level of significance and using 0.67 correlation value, a sample size of 75 was calculated. There are five stages of CVMS and in each CVM stage 15 subjects were allocated, therefore collective sample size was 75. The technique of sampling was purposive (non-probability) sampling. Out of 75 patients, 47 (62.7%) were males and 28 (37.3%) were females. The mean ages of the patients were 12.5 ± 2.6 years. Analysis of variance (ANOVA) test was performed to evaluate the blood serum IGF-1 levels among five stages of CVMS. RESULTS: There was a statistically considerable difference in mean IGF-1 among five stages of CVM. The mean IGF-1 (ng/ml) of CVMS 1 was 204.

Biological Maturation and Hormonal Markers, Relationship to Neuromotor Performance in Female Children

“…Thus, the results of the present study corroborate with the aforementioned studies and also with the statements of Sadiq et al, [10], where the authors highlighted that biological maturation is available for hormonal markers and that they can be used with different methods of the human body, cardiovascular, neurological and musculoskeletal system.…”

“…Typically, growth hormones reach a peak during the pubertal process [1,2,10,11]. In females, the growth hormone peak activates the hypothalamic-pituitary-ovary axis, promoting the production of estrogens (estradiol, estrone, estriol, and androstenedione) [1,4,12,13].…”

Serum biomarkers associated with radiographic skeletal maturity indicators: A systematic review and meta-analysis

“…A total of 11 studies (13 articles) with the cross-sectional study design (Anusuya et al, 2020; Gupta et al, 2015; Hussain et al, 2013; Ishaq et al, 2012; Jain et al, 2013, 2017; Masoud, 2008; Nancy et al, 2019; Sadiq et al, 2020; Sharmada et al, 2014; Sinha et al, 2016; Tripathi, 2017) utilised lateral cephalograms as the sole method of radiographic skeletal maturity assessment. Out of these studies, four (Ishaq et al, 2012; Jain et al, 2017; Sinha et al, 2016; Tripathi, 2017) used the Hassel and Farman (1995) CVMI staging, while seven (Anusuya et al, 2020; Gupta et al, 2015; Hussain et al, 2013; Jain et al, 2013; Nancy et al, 2019; Sadiq et al, 2020; Sharmada et al, 2014; Tripathi, 2017) used Baccetti et al (2005) CS staging.…”

“…A total of 11 studies (13 articles) with the cross-sectional study design (Anusuya et al, 2020; Gupta et al, 2015; Hussain et al, 2013; Ishaq et al, 2012; Jain et al, 2013, 2017; Masoud, 2008; Nancy et al, 2019; Sadiq et al, 2020; Sharmada et al, 2014; Sinha et al, 2016; Tripathi, 2017) utilised lateral cephalograms as the sole method of radiographic skeletal maturity assessment. Out of these studies, four (Ishaq et al, 2012; Jain et al, 2017; Sinha et al, 2016; Tripathi, 2017) used the Hassel and Farman (1995) CVMI staging, while seven (Anusuya et al, 2020; Gupta et al, 2015; Hussain et al, 2013; Jain et al, 2013; Nancy et al, 2019; Sadiq et al, 2020; Sharmada et al, 2014; Tripathi, 2017) used Baccetti et al (2005) CS staging. Though the CS staging by Baccetti et al (2005) was employed by eight studies, five studies—namely Anusuya et al (2020), Gupta et al (2015), Hussain et al (2013), Masoud (2008) and Sharmada et al (2014)—allocated their respective participants into six stages (CS 1–6) whereas Nancy et al (2019) and Sadiq et al (2020) did not include participants in the CS1 stage.…”

“…The type of sample, timing of collection, type of biomarker and the biomarker detection technique for the 19 studies are described in Table 2. Different biomarkers such as IGF-1, Gupta et al (2012Gupta et al ( , 2015, Ishaq et al (2012), Jain et al (2013), Nancy et al (2019), Phogat et al (2015), Sadiq et al (2020) and Sinha et al (2014Sinha et al ( , 2016. Srinivasan and Premkumar (2012) and Venkatagiriappa et al (2016) assessed the DHEA levels in serum and blood spot, respectively.…”