Correlation Between Serum Albumin and D-Dimer Levels in 909 Patients with Non-Valvular Atrial Fibrillation: A Retrospective Study from a Single Center in China

Abstract

Background D-dimer level can reflect the hypercoagulable state of atrial fibrillation (AF) and predict thromboembolic events. However, no effective indicator associated with D-dimer of AF patients has been found to prevent thromboembolic events in AF. This retrospective study from a single center aimed to investigate the correlation between serum albumin and D-dimer levels in 909 patients with non-valvular AF (NVAF) and 653 subjects in sinus rhythm. Material/Methods A total of 909 NVAF patients and 653 sex- and age-matched sinus rhythm participants were used to compare serum albumin and D-dimer levels. Serum albumin was determined by colorimetry, and D-dimer level was determined by latex-enhanced photoimmunoassay. We analyzed the correlation of serum albumin and D-dimer with NVAF by correlation analysis, logistic regression analysis, and receiver operating characteristic (ROC) curve. Results Albumin ( P <0.001) and D-dimer ( P <0.001) were significantly associated with NVAF. Among NVAF patients, D-dimer level was negatively correlated with albumin levels ( P <0.001), and albumin level was an independent risk factor of abnormal D-dimer level (>0.5 ug/mL), which was also an effective predictor of abnormal D-dimer level (the area under the ROC curve was 0.77, P <0.001), and the optimal cutoff value was 36.95 g/L. Conclusions Serum albumin and D-dimer levels were significantly associated with NVAF. In NVAF patients, D-dimer level was inversely correlated with albumin levels, and albumin level was an independent risk factor and effective predictor of abnormal D-dimer level. Close examination and supplementation of serum albumin can prevent thromboembolic events, but further clinical research and confirmation are needed.

Red cell distribution width to albumin ratio is a risk factor for atrial fibrillation in general population

“…Based on the mechanisms, recent study conducted in 909 patients with AF in China showed that AF patients had lower levels of albumin. Lower serum albumin levels was signi cantly associated with AF [22]. As reported, the patients with AF recurrence after ablation had a signi cantly higher level of red blood cell distribution width (RDW) at baseline than those with sinus rhythm [23].…”

Association of D-dimer to albumin ratio with adverse cardiovascular outcomes in ischaemic heart failure patients with diabetes mellitus: a retrospective cohort study

“…Yuan et al found that albumin and D-dimer were negatively related in the same cohort. In addition, both were significantly associated with non-valvular atrial fibrillation 13. It also found that in the same pulmonary embolism cohort, the median albumin levels were lower while D-dimer was higher than in patients without pulmonary embolism.…”

“…Recently, its utility in cardiovascular disorders is increasingly being recognised 8–12. For instance, Yuan et al found a significant association between serum albumin, D-dimer levels and non-valvular atrial fibrillation, with D-dimer levels being inversely correlated with albumin levels 13. Two retrospective studies investigated the diagnostic value of albumin and D-dimer in pulmonary embolism and found that lower plasma albumin and higher D-dimer were observed in patients with pulmonary embolism 12 14.…”

COVID severity test (CoST sensor)—An electrochemical immunosensing approach to stratify disease severity

“…Because of their unclear role in regulating coagulation during pathological events, abnormal D‐dimers are associated with many disease states such as sepsis, myocardial infarction, disseminated intravascular coagulation (DIC), and so on 17 . D‐dimer can also be associated for deep vein thrombosis, venous thromboembolism, DIC, stroke, and thrombosis in cancer and acute pulmonary embolism 23–28 . Although elevated D‐dimers have not been found in all patients with COVID‐19, they are commonly classified as a biomarker of prognosis and identified as an important risk factor for fatal organ injury 29 .…”

“…17 D-dimer can also be associated for deep vein thrombosis, venous thromboembolism, DIC, stroke, and thrombosis in cancer and acute pulmonary embolism. [23][24][25][26][27][28] Although elevated D-dimers have not been found in all patients with COVID-19, they are commonly classified as a biomarker of prognosis and identified as an important risk factor for fatal organ injury. 29 The correlation of D-dimer with clinical staging has been reported strongly to identify the disease severity stages depending on the D-dimer levels.…”