Correlation between serum 25-hydroxyvitamin D concentrations and regional cerebral blood flow in degenerative dementia

Farid, Karim; Volpe‐Gillot, Lisette; Petras, Slavomir; Plou, Caroline; Caillat-Vigneron, Nadine; Blacher, Jacques

doi:10.1097/mnm.0b013e32835674c4

Cited by 17 publications

(9 citation statements)

References 21 publications

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“…Data from the current study are consistent with recent findings that VitD: a) increases SOD activity, b) decreases levels of endogenous oxidants, c) attenuates H 2 O 2 induced changes, d) decreases release of inflammatory cytokines, and e) may have natural anti-oxidant and anti-inflammatory properties [106, 107]. In contrast, VitD deficiency contributes to inflammation through increased production of inflammatory cytokines, effects that are attenuated by 1,25(OH) 2 VitD supplementation [6, 13, 108, 109]. …”

Section: Discussionmentioning

confidence: 77%

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

Keeney

Förster

Sultana

et al. 2013

Free Radical Biology and Medicine

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In addition to the well-known effects of vitamin D (VitD) in maintaining bone health, there is increasing appreciation that this vitamin may serve important roles in other organs and tissues, including the brain. Given that VitD deficiency is especially widespread among the elderly, it is important to understand how the range of serum VitD levels that mimic those found in humans (from low to high) affects the brain during aging from middle-age to old-age. To address this issue, twenty-seven male F344 rats were split into three groups and fed isocaloric diets containing low (100 IU/kg food), control (1000 IU/kg food), or high (10000 IU/kg food) VitD beginning at middle-age (12 months) and continued for a period of 4–5 months. We compared the effects of these dietary VitD manipulations on oxidative and nitrosative stress measures in posterior brain cortices. The low VitD group showed global elevation of 3-nitrotyrosine (3-NT) compared to control and high VitD treated groups. Further investigation showed that this elevation may involve dysregulation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway and NF-κB mediated transcription of inducible nitric oxide synthase (iNOS) as indicated by translocation of NF-κB to the nucleus and elevation of iNOS levels. Proteomic techniques were used to provide insights into potential mechanisms underlying these effects. Several brain proteins were found at significantly elevated levels in low VitD group compared to the control and high VitD groups. Three of these proteins, 6-phosphofructokinase, triosephosphate isomerase, and pyruvate kinase, are involved directly in glycolysis. Two others, peroxiredoxin-3 and DJ-1/PARK7, have peroxidase activity and are found in mitochondria. Peptidyl-prolyl cis-trans isomerase A (PPIA or cyclophilin A) has been shown to have multiple roles including protein folding, regulation of protein kinases and phosphatases, immunoregulation, cell signaling, and redox status. Together, these results suggest that dietary VitD deficiency contributes to significant nitrosative stress in brain and may promote cognitive decline in middle-aged and elderly adults.

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Section: Discussionmentioning

confidence: 77%

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

Keeney

Förster

Sultana

et al. 2013

Free Radical Biology and Medicine

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“…Deleterious effects of hypovitaminosis D on vascular brain health have already been described. A recent SPECT-CT (radionuclide brain Single-Photon Emission Computed Tomography/Computed Tomography) study in participants with Alzheimer's disease found that serum 25OHD concentration positively correlated with cerebral blood flow, those with hypovitaminosis D having decreased regional blood flow in the left precuneus cortex [41]. Consistent with this result, a meta-analysis showed that in both cross-sectional and longitudinal studies people with hypovitaminosis D have more strokes than others [42].…”

Section: Discussionmentioning

confidence: 78%

Vitamin D and white matter abnormalities in older adults: a cross‐sectional neuroimaging study

Annweiler

Bartha

et al. 2014

Euro J of Neurology

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Background and purpose: Morphological brain changes related to hypovitaminosis D have been poorly studied. In particular, the age-related decrease in vitamin D concentrations may explain the onset of white matter abnormalities (WMA) in older adults. Our objectives were (i) to investigate whether there was an association between serum 25-hydroxyvitamin D (25OHD) concentration and the grade of WMA in older adults and (ii) to determine whether the location of WMA was associated with 25OHD concentration. Methods: One hundred and thirty-three Caucasian older community-dwellers with no clinical hydrocephalus (mean 71.6 AE 5.6 years; 43.6% female) received a blood test and a magnetic resonance imaging scan of the brain. The grades of total, periventricular and deep WMA were scored using semiquantitative visual rating scales from T2-weighted fluid-attenuated inversion recovery images. The association of WMA with as-measured and deseasonalized 25OHD concentrations was evaluated with the following covariates: age, gender, body mass index, use of anti-vascular drugs, number of comorbidities, impaired mobility, education level, Mini-Mental State Examination score, medial temporal lobe atrophy, serum concentrations of calcium, thyroid-stimulating hormone and vitamin B12, and estimated glomerular filtration rate. Results: Both as-measured and deseasonalized serum 25OHD concentrations were found to be inversely associated with the grade of total WMA (adjusted b = À0.32, P = 0.027), specifically with periventricular WMA (adjusted b = À0.15, P = 0.009) but not with deep WMA (adjusted b = À0.12, P = 0.090). Similarly, participants with 25OHD concentration <75 nM had on average a 33% higher grade of periventricular WMA than those with 25OHD ≥75 nM (P = 0.024). No difference in average grade was found for deep WMA (P = 0.949). Conclusions: Lower serum 25OHD concentration was associated with higher grade of WMA, particularly periventricular WMA. These findings provide a scientific basis for vitamin D replacement trials.

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“…The serum vitamin D level is associated with its activity in the brain. Serum 25(OH)D 3 concentration is correlated with regional cerebral blood flow (Farid et al., ), brain volume and gray matter thickness (Brouwer‐Brolsma et al., ; Buell et al., ; Hooshmand, Lökk, & Solomon, ) and clearance of aggregated Aβ in the AD brain (Durk et al., ; Masoumi, Goldenson, & Ghirmai, ; Yu et al., ). On the other hand, low serum 25(OH)D 3 is associated with neuronal damages (Gezen‐AK, Yilmazer, & Dursun, ), MCI (Annweiler et al., ), multidomain MCI (Yin et al., ) and AD (Annweiler et al., ; Balion, Griffith, & Strifler, ; Chei et al., ; Littlejohns, Henley, & Lang, ).…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D in patients with mild cognitive impairment and Alzheimer's disease

et al. 2018

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ObjectivesTo determine the relevance of Mini‐Mental State Examination (MMSE), serum 25‐hydroxyvitamin D (25(OH)D3), and 1,25(OH)2D3 concentrations to mild cognitive impairment (MCI) and various stages of Alzheimer's disease (AD).Materials and MethodsThe study included 230 participants (>74 years) allocated to three main groups: 1‐healthy subjects (HS, n = 61), 2‐patients with MCI (n = 61), and 3‐ patients with Alzheimer's disease (AD) subdivided into three stages: mild (n = 41), moderate (n = 35), and severe AD (n = 32). The cognitive status was evaluated using MMSE. Serum 25 (OH)D3 (ng/ml) and 1,25(OH)2D3 concentrations (pg/ml) were determined by competitive radioimmunoassay.Results MMSE scores and 25(OH)D3 were decreased in MCI and all stages of the AD in both genders. MMSE variability was due to gender in HS (11%) and to 25(OH)D3 in MCI (15%) and AD (26%). ROC analysis revealed an outstanding property of MMSE in diagnosis of MCI (AUC, 0.906; CI 95%, 0.847–0.965; sensitivity 82%; specificity, 98%) and AD (AUC, 0.997; CI 95%, 0.992–1; sensitivity, 100%; specificity, 98%). 25(OH)D3 exhibited good property in MCI (AUC, 0.765; CI 95%, 0.681–0.849; sensitivity, 90%; specificity, 54%) and an excellent property in diagnosis of AD (AUC, 0.843; CI 95%, 0.782–0.904; sensitivity, 97%; specificity, 79%). Logistic analyses revealed that, in MCI, MMSE could predict (or classify correctly) with 97.6% accuracy (Wald, 15.22, β, −0.162; SE, 0.554; OR = 0.115:0.039–0.341; p = .0001), whereas 25(OH)D3 with 80% accuracy (Wald, 41,013; β, −0.213; SE, 0.033; OR = 0.808: 0.757–863; p = .0001). 25(OH)D3 was the only significant predictor for the severe AD and contributed to MMSE variability. Age and gender were significant predictors only in the moderate AD. In patients with MCI, 25(OH)D3 and 1,25(OH)2D3 were correlated men, but in case of the AD, they were correlated in women.Conclusions MMSE and serum 25(OH)D3 concentrations could be useful biomarkers for prediction and diagnosis of MCI and various stages of the AD. The results support the utility of vitamin D supplementation in AD therapy regimen.

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Correlation between serum 25-hydroxyvitamin D concentrations and regional cerebral blood flow in degenerative dementia

Abstract: The results of this study confirm the relationship between 25-OHD concentrations and AD and therefore underline the hypothesis of a potential neuroprotective effect against brain degeneration. These encouraging findings need to be confirmed by larger prospective correlation series.

Cited by 17 publications

References 21 publications

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

Vitamin D and white matter abnormalities in older adults: a cross‐sectional neuroimaging study

Serum vitamin D in patients with mild cognitive impairment and Alzheimer's disease

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