Correlation between Serum 25-Hydroxy Vitamin D Levels and the Severity of Acne Vulgaris

Dewanti, Linda; Rasti, ShintaD; Dewinta, NenaR; Kamal, RonikH; Adissadah, AvinaF; Madanny, AfhamaE

doi:10.4103/ijd.ijd_871_21

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…Blood samples of all groups were obtained according to a standardized protocol. A broad laboratory fasting panel including nutritive parameters, such as IGF-1, glucose, insulin, HbA1c, fructosamine, cholesterol, triglycerides, HOMA-index ((insulin[µU/mL] × glucose [mg/dL])/405)) [25], and inflammatory markers (CRP and total leukocyte count), as well as vitamin D and zinc levels, was analyzed [26][27][28].…”

Section: Laboratory Parametersmentioning

confidence: 99%

Dietary Patterns in Acne and Rosacea Patients—A Controlled Study and Comprehensive Analysis

Guertler,

Volsky,

Eijkenboom

et al. 2023

Nutrients

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As the relationship between exposome factors and inflammatory skin diseases is gaining increasing attention, the objective of this study was to investigate dietary patterns among acne and rosacea patients and to establish the disease risk attributable to nutrition. In this cross-sectional, controlled study, patients’ dietary habits were assessed via subjective ratings of beneficial and trigger foods, followed by standardized food frequency surveys (FFS). Scores for disease-specific risk stratification based on dietary habits were proposed. Clinical assessments, dermatologic examinations, and laboratory analyses were performed. A total of 296 patients (acne group (AG) n = 120, control group (ACG) n = 32; rosacea group (RG) n = 105, control group (RCG) n = 39) were included. The significant impact of diet on disease severity was self-reported by 80.8% of the AG and 70.5% of the RG. Leading dietary triggers were found in both groups, while beneficial food items were identified more clearly by the AG. FFS revealed significant dietary differences between the AG, RG, and control groups. Disease-specific scores showed greater precision for acne (odds ratio 14.5 AG, 5.5 RG). The AG had higher insulin-like growth factor (IGF)-1 levels correlating with dairy intake (p = 0.006). Overall, this study underlines the influence of diet on acne and rosacea, providing valuable disease-specific scores for dietary risk stratification. Consuming vegetables, legumes, oily fish, olive oil, and nuts, and limiting meat, cheese, and alcohol appear to be beneficial for both acne and rosacea. Future studies can build on these data to further improve preventive and therapeutic strategies.

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Section: Laboratory Parametersmentioning

confidence: 99%

Dietary Patterns in Acne and Rosacea Patients—A Controlled Study and Comprehensive Analysis

Guertler,

Volsky,

Eijkenboom

et al. 2023

Nutrients

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“…22 In contrast to our finding a systemic review included 10 studies found that all studies (8 of 10) revealed lower serum 25-hydroxy vitamin D levels as the acne severity progresses, although 2 of them were not statistically significant. 23 A small sample size case control study (33 cases and 25 controls receiving vitamin D supplement) in Iraq found that vitamin D deficiency was more frequent in patients with acne, which was inversely related with disease severity, however patient in control group had receive vitamin D supplementation. 24 Another case control study showed vitamin D deficiency is evident in acne vulgaris patients and a statistically significant association with the severity of acne lesions, that included 162 unmarried females only, of 12-30 years of age and Vitamin D levels were sorted as adequate (>30 ng/ml), while in this study the age group was 12-40 years and vitamin D was sorted as sufficient (≥20 ng/ml).…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Vitamin D, Body Mass Index and some Dietary Products with Acne Vulgaris; A Case-Control study in Baghdad/Iraq

Zalzala,

Ali,

Fahad

2024

J. Contemp. Med. Sci.

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Objective: To investigate the association of vitamin D level and moderate to severe acne as a primary outcome, and its association with BMI, dairy products, and chocolate consumption. Subjects and Methods: A case-control study was conducted in a dermatology outpatient clinic. Patients, diagnosed with moderate to severe acne vulgaris that warrant treatment with oral antibiotics, and had global acne grading system (GAGS) score of >=19 were eligible to be selected as cases. Aged matched, with no or mild cases of acne were eligible to be selected as controls. The participant height, weight, BMI, and serum circulating 25-hydroxyvitamin D level were measured. A modified food frequency questionnaire was used for dietary history. Results: Comparing Cases (N = 101) and Control (N = 134), the mean of vitamin D level in cases were lower than that in the controls, however no statistically significant difference is observed. There were statistically insignificant differences between the studied groups regarding milk (whole, low fat, skimmed and any type of milk), cheese, yogurt, other dairy products, and chocolate consumption. However, a statistically significant disparity in weight is noted, but not in BMI. Conclusion: The results did not reveal any statistically significant associations between vitamin D level, BMI, dairy and chocolate consumption, and moderate to severe acne. However, it is important to note that this does not definitively rule out the possibility of any potential relationships or effects.

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“…Vitamin D possesses anti-comedogenic and also antioxidant effects. Consequently, its deficit may promote the development of acne [ 66 ].…”

Section: Reviewmentioning

confidence: 99%

“…The target cells for physiologically active vitamin D metabolites are human sebocytes and keratinocytes, which are reached by nuclear VDRs [ 68 ]. It has been noted that vitamin D3 inhibits keratinocyte proliferation and promotes keratinocyte differentiation [ 66 ]. This is explained by the VDR-mediated genetic effect that causes an arrest of sebocytes in the G1 phase, which in turn prevents cell proliferation [ 69 ].…”

Section: Reviewmentioning

confidence: 99%

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The Non-conventional Effects of Hypovitaminosis D: A Pandemic Even in Sunlight-Rich Countries

Qureshi,

Khemissa,

Amr

et al. 2024

Cureus

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The synthesis and absorption of Vitamin D play crucial roles in numerous bodily functions, yet deficiencies persist due to factors like insufficient sunlight exposure and dietary inadequacy. Research underscores the significance of lifestyle elements such as diet, sun exposure, and physical activity in maintaining optimal Vitamin D levels. Strategies aimed at tackling deficiencies emphasize supplementation alongside lifestyle adjustments, especially in regions with abundant sunlight like the Middle East and North Africa (MENA). Despite the abundance of sunshine in the Arab world, there remains a prevalent issue of Vitamin D deficiency. This problem arises from various factors, including cultural practices such as traditional clothing covering most skin areas, which limit sun exposure, and environmental factors like air pollution that reduce UV penetration. Dietary habits and lifestyle choices also contribute to this deficiency. Dealing with the ongoing pandemic requires a focused effort to enhance awareness. While some individuals may recognize common diseases caused by Vitamin D deficiency, such as rickets and osteomalacia, many remain unaware of the broader health risks associated with the condition, including non-skeletal manifestations. Additionally, there is a lack of understanding regarding the numerous hidden benefits of this hormone. Therefore, prioritizing educational initiatives that delve into these aspects is essential to effectively combat the current health crisis. This literature review aims to report both skeletal and extraskeletal consequences of hypovitaminosis and briefly discuss the cause of paradoxical vitamin D deficiency in sunny regions like the MENA. This was done by reviewing pertinent articles published between January 2000 and January 2024, sourced from databases such as PubMed, UpToDate, Scopus, and CINAHL, focusing exclusively on English language literature and using keywords such as “Vitamin D deficiency” and “Extraskeletal manifestations.”

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Correlation between Serum 25-Hydroxy Vitamin D Levels and the Severity of Acne Vulgaris

Cited by 5 publications

References 23 publications

Dietary Patterns in Acne and Rosacea Patients—A Controlled Study and Comprehensive Analysis

Dietary Patterns in Acne and Rosacea Patients—A Controlled Study and Comprehensive Analysis

The Relationship between Vitamin D, Body Mass Index and some Dietary Products with Acne Vulgaris; A Case-Control study in Baghdad/Iraq

The Non-conventional Effects of Hypovitaminosis D: A Pandemic Even in Sunlight-Rich Countries

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