Correlation between Serotonin Transporter Promoter Gene Polymorphism and PTSD in Children

Abstract

Objective: To study the association between post-traumatic stress disorder (PTSD) and serotonin transporter promoter (5-HTTLPR) gene polymorphism in Han children in Hainan; to explore the genetic mechanism of PTSD in children. Methods: 50 patients with post-traumatic stress disorder and healthy children in Han nationality in Hainan were selected. Detection of 5-HTTLPR gene polymorphism by polymerase chain reaction (PCR) and amplified fragment length polymorphism, the genotype and allele frequencies were analyzed using a case-control association analysis method. Results: There were 4, 14 and 32 cases of LL, SL and SS in the post-traumatic stress disorder group of Hainan Han children, and 13, 20 and 17 cases in the control group. From the perspective of gene frequency, the L gene of post-traumatic stress disorder appeared 22.0%, and S appeared 78.0%. In the control group, L appeared 46.0%, and S appeared 54.0%. There were significant differences in genotype and gene frequency (P < 0.01). Conclusion: The 5-HTTLPR gene polymorphism in Hainan Han children may be associated with post-traumatic stress disorder.

Meta-analysis of 5-hydroxytryptamine transporter gene promoter region polymorphism and post-stroke depression

“…Nine articles met the inclusion criteria. 24,25,27,32–37 There were 855 patients in the PSD group and 981 patients in the non-PSD group. The study selection procedure is shown in Figure 1.…”

“…Numerous studies have examined the effects of 5-HTTLPR gene polymorphism and its interaction with the environment on depression, 45 and the S allele or S/S genotype was shown to be a risk factor for PSD. 32,33 However, clinical studies generally include small sample sizes, and further studies with larger sample sizes are needed to support this conclusion. The current study therefore applied a meta-analysis to analyze the relationship between HTTLPR gene polymorphism and PSD, to provide more evidence for clinical guidance.…”

“…Nine articles 24,25,27,32–37 were included in this study, of which seven were conducted in Asians and two in Caucasians. The results showed a strong correlation between HTTLPR gene polymorphism and PSD, with significant differences in allele, dominant, recessive, homozygous, and heterozygous genetic models.…”