Correlation Between Serial Changes in Left-sided Heart Chambers and Atrial Natriuretic Peptide and N-terminal Pro Atrial Natriuretic Peptide after a First Myocardial Infarction: An Echocardiographic Study

Svanegaard, Jens; Johansen, Jens Brock; Klitgaard, N. A.; Thayssen, Per; Haghfelt, Torben

doi:10.1080/14017439950141425

Cited by 5 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Postoperative symptomatic improvement following surgery for aortic stenosis may be predicted using left atrial size 1. An echocardiographic study2 found a significant correlation between left atrial size and atrial natriuretic peptide levels after acute myocardial infarction both at 10 to 12 days post infarction as well as at six months. Based on a correlation coefficient of 0.70, it was concluded that the percentage change in the size of the left atrium could reliably predict the percentage change in atrial natriuretic peptide after an acute myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

The reliability of chest radiographs in predicting left atrial enlargement

Quinton¹,

Ker²,

Rheeder³

et al. 2010

CardioVascular Journal of Africa

View full text Add to dashboard Cite

IntroductionEstimates of left atrial size in patients with suspected cardiac disease play an important role in predicting prognosis and events, as well as treatment decisions. Two methods are commonly used to estimate left atrial size: chest radiography and cardiac ultrasound. This study aims to determine the test characteristics by comparing the use of radiographs to cardiac ultrasound (the gold-standard test).MethodsData from patients older than 18 years admitted to Steve Biko Academic Hospital during 2000–2003 who had both chest radiographs and cardiac ultrasound were included in this cross-sectional, retrospective analysis. Chest radiographs were classified into three quality classes, and the sub-carinal angle (SCA) and sub-angle distance (SAD) were measured twice in all available radiographs by two observers. Intra- and inter-observer variability (three methods) as well as the predictive value of the carinal angle and sub-angle distance measurements were determined using logistic regression (with left atrial enlargement – determined by ultrasound as comparator).ResultsData for 159 patients were available (154 cardiac ultrasounds and 178 chest radiographs). Intra-observer variability for chest radiograph measurements was low with almost perfect concordance (p = 0.000). Inter-observer variability was higher for supine radiographs. Using logistic regression, a linear model was identified which was statistically significant only for erect radiographs. While goodness-of-fit analysis showed that the model fits the data, performance characteristics were poor, with high sensitivity and low specificity, and an area under the ROC curve of 0.62–0.63, depending on type of radiograph and measurement (SCA or SAD). Linearity in the logit of the dependent variable was assessed, and found to be present at the extremes of SCA measurements for the supine radiograph data and in the first three quartiles for erect radiograph data. A non-linear model determined by fractional polynomial analysis did not perform significantly better than the original linear model. Cut-off values for the SCA of 72° and 84° (erect and supine radiographs, respectively) were found to give the best compromise between sensitivity and specificity. The corresponding cut-off values for SAD were 24.1 and 26.9 mm.ConclusionAssessment of either SCA or SAD to determine left atrial size was equivalent and repeatable, both with the same observer and between two observers (less so for supine radiographs). While this measure was precise, it was found not to be very accurate. Therefore, chest radiographs are not reliable in predicting left atrial enlargement.

show abstract

Section: Discussionmentioning

confidence: 99%

The reliability of chest radiographs in predicting left atrial enlargement

Quinton¹,

Ker²,

Rheeder³

et al. 2010

CardioVascular Journal of Africa

View full text Add to dashboard Cite

show abstract

“…The approximate ANP plasma half-time is approximately 2–3 min. Released in equimolar amounts NT-proANP, slowly eliminated by kidneys, appears to have more practical diagnostic use [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Atrial Natriuretic Peptides, Right Atrial Infarction and Prognosis of Patients with Myocardial Infarction—A Single-Center Study

2021

View full text Add to dashboard Cite

Atrial natriuretic peptide (ANP) is secreted in response to the stretching of the atrial wall. Atrial ischemia most likely impairs the ability of atrial myocytes to produce ANP. Atrial infarction (AI) is rarely diagnosed but not infrequently associated with myocardial infarction (MI). The aim of the study was to assess the association between AI and the prognostic value of N-terminal proANP (NT-proANP) in patients with MI treated with primary percutaneous coronary intervention (PCI). We evaluated data of 100 consecutive patients. Plasma levels of NT-proANP were measured by the ELISA method. ECG recordings were interpreted to diagnose AI according to Liu’s criteria. All patients were followed-up prospectively for 12 months for the manifestation of major adverse cardiovascular events (MACE), defined as unplanned coronary revascularization, stroke, reinfarction or all-cause death. AI was diagnosed in 36 patients. 14% of patients developed MACE. AI did not affect the incidence of MACE or any of its components, nor the patients’ prognosis. NT-proANP revealed to be a strong predictor of death but was not associated with other adverse events. Conclusions: AI in patients with MI treated with primary PCI is not connected with their prognosis nor affects the usefulness of NT-proANP in predicting death during the 12-month follow-up.

show abstract