Correlation between renin-angiotensin system (RAS) related genes, type 2 diabetes, and cancer: Insights from metanalysis of transcriptomics data

Pereira, Luciana Xavier; Silva, Laryssa Cristina Alves da; Feitosa, Alexya de Oliveira; Ferreira, Ricardo Jansen Santos; Duarte, Ana Kelly Fernandes; Conceição, Valdemir da; Marques, Carolinne de Sales; Rodrigues, Amanda Karine Barros Ferreira; Koike, Bruna Del Vechio; Queiroz, Aline Cavalcanti de; Guimarães, Talita Antunes; Souza, Carlos Dornels Freire de; Fraga, Carlos Alberto de Carvalho

doi:10.1016/j.mce.2019.110455

Cited by 7 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…83 The renin-angiotensin system (RAS) is closely associated with the pathogenesis of insulin resistance/diabetes, 84 and RAS inhibition improves insulin sensitivity in humans. 85 In our study, PIK3CD and PIK3R5 were enriched in all relevant significantly downregulated pathways. Consistent with our findings, PIK3CD expression was significantly reduced in T2DM in a previous study.…”

Section: Discussionsupporting

confidence: 51%

See 1 more Smart Citation

Genome-Wide Identification of lncRNA and mRNA for Diagnosing Type 2 Diabetes in Saudi Arabia

Albogami

2023

PGPM

View full text Add to dashboard Cite

According to the World Health Organization, Saudi Arabia ranks seventh worldwide in the number of patients with diabetes mellitus. To our knowledge, no research has addressed the potential of noncoding RNA as a diagnostic and/or management biomarker for patients with type 2 diabetes mellitus (T2DM) living in high-altitude areas. This study aimed to identify molecular biomarkers influencing patients with T2DM living in high-altitude areas by analyzing lncRNA and mRNA. Patients and Methods: RNA sequencing and bioinformatics analyses were used to identify significantly expressed lncRNAs and mRNAs in T2DM and healthy control groups. Coding potential was analyzed using coding-noncoding indices, the coding potential calculator, and PFAM, and the lncRNA function was predicted using Pearson's correlation. Differentially expressed transcripts between the groups were identified, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to identify the biological functions of both lncRNAs and mRNAs. Results: We assembled 1766 lncRNAs in the T2DM group, of which 582 were novel. This study identified three lncRNA target genes (KLF2, CREBBP, and REL) and seven mRNAs (PIK3CD, PIK3R5, IL6R, TYK2, ZAP70, LAMTOR4, and SSH2) significantly enriched in important pathways, playing a role in the progression of T2DM. Conclusion:To the best of our knowledge, this comprehensive study is the first to explore the applicability of certain lncRNAs as diagnostic or management biomarkers for T2DM in females in Taif City, Saudi Arabia through the genome-wide identification of lncRNA and mRNA profiling using RNA seq and bioinformatics analysis. Our findings could help in the early diagnosis of T2DM and in designing effective therapeutic targets.

show abstract

Section: Discussionsupporting

confidence: 51%

“… 83 The renin–angiotensin system (RAS) is closely associated with the pathogenesis of insulin resistance/diabetes, 84 and RAS inhibition improves insulin sensitivity in humans. 85 …”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Identification of lncRNA and mRNA for Diagnosing Type 2 Diabetes in Saudi Arabia

Albogami

2023

PGPM

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that compared with the general population, patients with T2DM have a higher risk of malignancies, such as endometrial, colorectal, liver, pancreatic, breast, and urinary tract cancer, including kidney and BC [ 16 , 18 , 23 , 24 , 25 ]. Studies undertaken to explore the mechanisms of T2DM and changes in the renin–angiotensin system that might lead to carcinogenesis [ 26 ] found probable associations with hyperglycemia, inflammation, insulin resistance, and hormonal dysregulation [ 26 ]. However, in our study ( Figure 2 ), T2DM patients did not have a higher risk of BC.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study

Pan

Lee

et al. 2020

Medicina

View full text Add to dashboard Cite

Background and objectives: Type 2 diabetes mellitus (T2DM) is becoming increasingly prevalent worldwide and is associated with increased incidence of kidney cancer and bladder cancer (BC). However, studies have produced conflicting results. Therefore, we retrospectively evaluated the incidence of BC in T2DM patients using the Taiwan National Health Insurance Research Database (NHIRD). Materials and Methods: We included 31,932 patients with a diagnosis of T2DM in the study group and 63,864 age- and sex-matched patients without T2DM at a ratio of 1:2 in the control group. The primary outcome was the diagnosis of BC. Cox proportional hazards regression was used to evaluate the incidence and adjusted hazard ratio (aHR) of BC in the multivariate model. Results: After a 16-year follow-up, we found that 67 BC cases occurred in the study group and 152 BC events in the non-T2DM group without a significantly higher risk (aHR: 0.842, 95% confidence interval: 0.627–1.13). Conclusions: T2DM patients do not have a higher risk of BC.

show abstract

“…Differentially expressed gene analysis RNA-seq and clinical information data from Geodataset and The Cancer Genome Atlas (TCGA) were performed as previously described [31][32][33] .Basically, we used TCGAbiolinks and the TCGAbiolinksGUI R package to compare differentially expressed genes (DEGs) in normal and melanoma (SKCM) and oral squamous cell carcinoma (OSCC). Normal samples were obtained from The Genotype-Tissue Expression (GTEx) project.…”

Section: Methodsmentioning

confidence: 99%

Clock-related genes disruption and melatonin administration are associated with melanoma and oral cancer, but not with skin carcinoma

Duarte,

Gomes,

Rocha

et al. 2024

Preprint

View full text Add to dashboard Cite

Melatonin plays an important role in the regulation of circadian clock genes, whose deregulation contributes to cancer development. In this study, we first performed a bioinformatic analysis for melanoma, non-melanoma skin cancer, and oral squamous cell carcinoma to evaluate what clock-related genes are deregulated when compared to normal tissue. Further, we administrated melatonin in cell cultures for cutaneous squamous cell carcinoma, skin melanoma, and oral squamous cell carcinoma to observe changes in cancer cell phenotypes. Later, we evaluated gene expressions associated to clock genes, cancer cell proliferation, migration, invasion, and apoptosis. In summary, clock-related genes are deregulated in both cancers. Skin melanoma and oral cancer presented commonly deregulated clock related genes and were associated with poor survival and chemoresistance, according to bioinformatic analysis. In cell culture, melatonin administration increased Per2, Cry1, Cry2 and Bmal1 mRNA expression levels and decreased Clock gene mRNA levels. Per2, Cry1, Cry2, and Bmal1 genes belong to tumor suppressor genes that can control cell proliferation, cell death, DNA damage, and repair system. Te hypothesized that changes in the expression of clock related-genes in cancer could be responsible for metabolic changes that could lead to the cancer aggressiveness. Melatonin administration showed changes in melanoma and oral cancer phenotypes. Melatonin also seems to influence melanoma and oral tumor progression through Mki67, Hif-1a, Vegfa, Col1a1, Cdh1, Casp3, Bax, Bcl2, Mmp9, Per2, Cry1, Cry2, Bmal1 and Clock modulation.

show abstract

Correlation between renin-angiotensin system (RAS) related genes, type 2 diabetes, and cancer: Insights from metanalysis of transcriptomics data

Cited by 7 publications

References 39 publications

Genome-Wide Identification of lncRNA and mRNA for Diagnosing Type 2 Diabetes in Saudi Arabia

Genome-Wide Identification of lncRNA and mRNA for Diagnosing Type 2 Diabetes in Saudi Arabia

Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study

Clock-related genes disruption and melatonin administration are associated with melanoma and oral cancer, but not with skin carcinoma

Contact Info

Product

Resources

About