Correlation between renin-angiotensin system gene polymorphisms and essential hypertension in the Chinese Yi ethnic group

Abstract

Introduction: The renin-angiotensin system (RAS) has been considered to play an important role in the regulation of blood pressure. This study aimed to investigate the correlation between RAS gene polymorphisms and essential hypertension (EH) in the Chinese Yi ethnic group. Materials and methods: A total of 244 EH subjects and 185 normotensive individuals from the Chinese Yi ethnic group were genotyped for AGT M235T (rs699), AT1R A1166C (rs5186), ACE I/D (rs4340) and ACE G2350A (rs4343) polymorphisms by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. Results: Significant differences in the allele and genotype frequency of ACE G2350A were observed between the EH cases and controls (p=0.001, 0.002). After being grouped by gender, significant differences in the allele and genotype frequency of ACE G2350A and AT1R A1166C were observed between females of the EH cases and controls (ACE G2350A: p=0.000, 0.002; AT1R A1166C: p=0.008, 0.011). After excluding the influence of multifactorial interactions, the ACE G2350A polymorphism is significantly associated with the pathogenesis of EH in the Chinese Yi ethnic group (odds ratio (OR)=1.656, 95% confidence interval (CI) 1.807–2.524, p=0.019). Conclusions: The RAS-related ACE G2350A polymorphism is associated with the pathogenesis of EH in the Chinese Yi ethnic group.

Angiotensin-Converting Enzyme ID Polymorphism in Patients with Heart Failure Secondary to Chagas Disease

“…HF patients had lower blood pressure than patients with Chagas disease without systolic dysfunction (p = 0.000), which is in agreement with the study by Yang et al. 17 who investigated ACE I/D genotype in a Chinese population. There were no significant differences in the frequency of alleles or genotypes between the groups in both sexes.…”

Relationship of renin‐angiotensin system polymorphisms with ambulatory and central blood pressure in patients with hypertension

“…However, the mechanism responsible for the association of hypertension risk with A1166C polymorphism remains unclear. A possible explanation for this is that the A1166C polymorphism affects the binding between AT1R and angiotensin II, thereby affecting the ability of angiotensin II to act as a vasoconstrictor and increase BP …”

“…First, the size of the sample was small, partly because it is difficult to select patients with untreated hypertension without other concomitant diseases. Second, in our study, only three RAS genetic variants were assayed, which contain a group of promising candidate genes involved in essential hypertension and play a key role in BP regulation, especially for central BP. Last, the cross‐sectional study design is another limitation of the present study.…”

Angiotensin‐converting enzyme gene rs4343 polymorphism increases susceptibility to migraine

“…The GG genotype of the ACE rs43434 polymorphism was significantly more frequent in the patients with essential hypertension, left ventricular hypertrophy, and coronary artery diseases. 8,9 Moreover, hypertension, one of the common risk factors for migraine and CVDs, is associated with rs4343. 6 Therefore, the GG genotype can be considered as a genetic factor for increasing the risk of migraine and CVDs.…”