Correlation between regional cerebral blood flow and brain atrophy in dementia. Combined study with 133Xenon inhalation and computerised tomography.

Melamed, Eldad; Lavy, S; Siew, Fred; Bentin, Shlomo; Cooper, Gerald R.

doi:10.1136/jnnp.41.10.894

Cited by 30 publications

(5 citation statements)

References 27 publications

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“…These findings are consistent with our own results. Yamaguchi et al [13] reported that CBF was closely correlated with brain atrophy in normal elderly sub jects; however, Melamed et al [14] reported that there was no correlation between CBF values and severity of ventricular dilatation or cortical atrophy in patients with presenile or senile dementia. There have been, how ever, few reports on the relation between CBF and brain atrophy in MID.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Carotid Blood Flow and Brain Atrophy in Patients with Multi-Infarct Dementia

Yamashita

Kobayashi²,

Yamaguchi³

et al. 1989

Gerontology

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The relation between carotid blood flow measured by Doppler spectrum analysis and brain atrophy on computed tomography (CT) was studied in 22 subjects with multiple lacunar cerebral infarctions. The subjects were divided into two groups, 7 patients with multi-infarct dementia (MID) (mean age 73 years) and 15 nondemented lacunar stroke subjects (NDLS) (mean age 66 years), according to DSM III criteria. All subjects had a score of 7 points or more on Hachinski’s ischemic score and showed no carotid artery stenosis. Systolic peak frequency of the common carotid artery (CCA) was measured by Doppler spectrum analysis (Angioscan II). Brain atrophy was measured quantitatively on CT images by two-dimensional measurement using a digitizer. Peak frequencies were lower in MID than in NDLS. Brain atrophy was more severe in MID than in NDLS. There was a significant correlation between peak frequencies and brain atrophy in all subjects. These results indicate that CCA blood flow may reflect brain function in patients with multiple lacunar infarctions.

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Section: Discussionmentioning

confidence: 99%

Correlation between Carotid Blood Flow and Brain Atrophy in Patients with Multi-Infarct Dementia

Yamashita

Kobayashi²,

Yamaguchi³

et al. 1989

Gerontology

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“…Characteristic striatal atrophy accompanied by ventricular dilatation and cortical sulcal widening have been demonstrated by pneumoencephalography [7] and computed tomography (CT) [2,34, 451. Although extensive studies have been performed in presenile and senile dementia using measurements of cerebral blood flow (CBF) [21,31, 331, oxygen utilization [16,17, 291, and glucose utilization (CMRgI,) [5, 13, 191, these methods have rarely been applied to H D .The necessity of measuring brain function, blood flow, metabolism, and structure locally rather than globally is now recognized. Previously, we found that in both stroke [27] and epilepsy [25], altered lo-cal glucose utilization (LCMR,,,), determined by positron emission computed tomography of 18Ffluorodeoxyglucose (FDG) [36, 381, is a more sensitive indicator of altered local cerebral function than is the accompanying structural abnormality determined by CT.…”

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confidence: 99%

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confidence: 99%

Cerebral metabolism and atrophy in huntington's disease determined by ¹⁸FDG and computed tomographic scan

Kuhl

Phelps

Markham

et al. 1982

Annals of Neurology

438

119

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Patterns of local cerebral glucose utilization were measured with positron emission, computed tomography using the 18F-fluorodeoxyglucose method in 13 patients with Huntington's disease (HD), 15 subjects at risk for HD, and 40 normal control subjects. These data were compared with computed tomographic measures of cerebral atrophy, with age, and with duration and severity of symptoms. The results indicate that in HD there is a characteristic decrease in glucose utilization in the caudate and putamen and that this local hypometabolism appears early and precedes bulk tissue loss. In contrast to patients with senile dementia, in these HD patients glucose utilization typically was normal throughout the rest of the brain, regardless of the severity of symptoms and despite apparent shrinkage of brain tissue. Our results suggest the possibility that the caudate may be hypometabolic in some asymptomatic subjects who are potential carriers of the autosomal dominant gene for HD.

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“…As well, a decrease in cerebral blood flow (CBF) may be associated with brain atrophy. However, previous studies have failed to find a significant relationship between CBF and brain atrophy in patients with dementia [7,8,9]. In patients with cerebral artery occlusive disease, atrophy of the corpus callosum was reported to progress in concert with the deterioration of cerebral cortical oxygen metabolism in small population studies [10, 11].…”

Section: Introductionmentioning

confidence: 99%

Changes in Brain Volume 2 Years after Extracranial-Intracranial Bypass Surgery: A Preliminary Subanalysis of the Japanese EC-IC Trial

Jinnouchi¹,

Toyoda²,

Inoue³

et al. 2006

Cerebrovasc Dis

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Background and Methods: We studied changes in brain volume on magnetic resonance imaging in 10 patients with and without extracranial-intracranial (EC-IC) bypass surgery who met the inclusion criteria for the Japanese EC-IC Bypass Trial, a multicenter, randomized, prospective study of patients with hemodynamic brain ischemia due to cerebral artery occlusive disease. We also examined the association of cerebral hemodynamics on single-photon emission computed tomography with the changes in brain volume. Results: The affected/unaffected ratio of the percent brain volume declined in patients without EC-IC bypass surgery (p < 0.02, n = 4), and the affected/unaffected percent regional cerebral blood flow ratio increased in patients with the surgery (p < 0.03, n = 6). Acetazolamide reactivity increased in the affected hemisphere of patients with surgery (p < 0.01). Two-year increase (decrease) in acetazolamide reactivity of the affected hemisphere showed a significant positive correlation with 2-year changes in the affected/unaffected percent brain volume ratio (R² = 0.737, p = 0.0007). Conclusions: Change in acetazolamide reactivity might be a good predictor for brain atrophy in cerebral artery occlusive disease.

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Correlation between regional cerebral blood flow and brain atrophy in dementia. Combined study with 133Xenon inhalation and computerised tomography.

Cited by 30 publications

References 27 publications

Correlation between Carotid Blood Flow and Brain Atrophy in Patients with Multi-Infarct Dementia

Correlation between Carotid Blood Flow and Brain Atrophy in Patients with Multi-Infarct Dementia

Cerebral metabolism and atrophy in huntington's disease determined by ¹⁸FDG and computed tomographic scan

Changes in Brain Volume 2 Years after Extracranial-Intracranial Bypass Surgery: A Preliminary Subanalysis of the Japanese EC-IC Trial

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Correlation between regional cerebral blood flow and brain atrophy in dementia. Combined study with 133Xenon inhalation and computerised tomography.

Cited by 30 publications

References 27 publications

Correlation between Carotid Blood Flow and Brain Atrophy in Patients with Multi-Infarct Dementia

Correlation between Carotid Blood Flow and Brain Atrophy in Patients with Multi-Infarct Dementia

Cerebral metabolism and atrophy in huntington's disease determined by 18FDG and computed tomographic scan

Changes in Brain Volume 2 Years after Extracranial-Intracranial Bypass Surgery: A Preliminary Subanalysis of the Japanese EC-IC Trial

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Cerebral metabolism and atrophy in huntington's disease determined by ¹⁸FDG and computed tomographic scan