Correlation Between Quantitative Perfusion Histogram Parameters of DCE-MRI and PTEN, P-Akt and m-TOR in Different Pathological Types of Lung Cancer

Qian, Zhendong; Zhao, Zhenhua; Huang, Yanan; Mao, Haijia; Zou, Mingyue; Wang, Cheng; Yu, Guanzhen; Zhang, Minming

doi:10.21203/rs.3.rs-88677/v1

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Our results showed that there was a statistical difference in the expression level of Ki-67 index in patients with 3 different pathological types of lung cancer (H=103.762, P=0.000). The results are similar to those reported by previous researchers ( 14 ). It also indicates that the participants in our study are suitable for further study of the correlation analysis between Ki-67 index and image features.…”

Section: Discussionsupporting

confidence: 93%

Correlation between apparent diffusion coefficient and Ki-67 in different pathological types of lung cancer

Ren¹,

Ma²,

Jia³

2021

Transl Cancer Res TCR

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Background: Computed tomography (CT) is common and valuable non-invasive method to evaluate proliferative activity in lung cancer; however, magnetic resonance (MR) is rarely used in lung cancer. To evaluate whether there were different expression levels of Ki-67 in different pathological types of lung cancer and the correlation between Ki-67 index and apparent diffusion coefficient (ADC) value. Methods:The clinical and pathological data of 165 patients with lung cancer confirmed by needle biopsy or surgery were retrospectively evaluated, among whom 54 underwent MR examination. The level of Ki-67 was tested using the international standard IHC 2-step method. Kruskal-Wallis H test was used to compare the different expression level of Ki-67 index of adenocarcinoma, squamous cell carcinoma, and small cell carcinoma, and the least significant difference (LSD) method was used for pair-group comparison. Spearman correlation coefficient was used to analyze the correlation between Ki-67 index and ADC value. All statistical tests were bilateral, and P<0.05 was considered statistically significant. Results:The median of Ki-67 index in adenocarcinoma, squamous cell carcinoma, and small cell carcinoma were 20 (10, 30), 40 (40, 60), and 70 (60, 80), respectively. There was a statistical difference in the expression level of Ki-67 index in the 3 different pathological types of lung cancer (H=103.762, P=0.000). In 54 cases of lung cancer with MR examination, there was a significant negative correlation between average ADC value and expression level of Ki-67 index (r=−0.506, P=0.000), while there was no correlation between ADC value and Ki-67 index in distinguishing different pathological types of lung cancer. Conclusions:The expression level of Ki-67 index was different among different pathological types of lung cancer. The ADC value is correlated with Ki-67 index in lung cancer, which can be used to evaluate the proliferative activity of lung cancer.

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Section: Discussionsupporting

confidence: 93%

Correlation between apparent diffusion coefficient and Ki-67 in different pathological types of lung cancer

Ren¹,

Ma²,

Jia³

2021

Transl Cancer Res TCR

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“…Previous studies of MRI mainly focus on malignant tumor such as breast cancer and lung cancer. Scholars have found that there was a negative relationship between ADC and Ki-67 index (11)(12). Therefore, the ADC has the potential to re ect the growth of the tumor cell to a certain extent while it is limited as an alternative marker to re ect the proliferation potential (13).…”

Section: Introductionmentioning

confidence: 99%

Correlations between Diffusion-Weighted and Intravoxel Incoherent Motion Parameters with Ki-67 Index in Gastric Adenocarcinoma

Yuan

Lin

Zhao

et al. 2022

Preprint

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Background：Intravoxel incoherent motion imaging (IVIM) and DWI have been applied for gastric adenocarcinoma.Purpose: To investigate correlation between parameters of IVIM and DWI with Ki-67 in gastric adenocarcinoma.Materials and methods: A total of 64 gastric adenocarcinoma patients were enrolled into the research and received DWI and IVIM at 3.0T MRI before the surgery. Based on the setting of ROIs, the DWI and IVIM parameters (including ADC, ture diffusion coefficient (D), perfusion fraction (f) and pseudo-diffusion coefficient (D*)) of each patient's gastric adenocarcinoma were measured and calculated. According to expression of Ki-67, participated subjects were divided into two groups (low Ki-67 group and high Ki-67 group). The intraclass correlation coeffificient (ICC) was used to assess the consistency of each parameter measured by two radiologists. The independent-sample t-test was used to compare differences of each parameter between groups. Spearman correlation coefficient was calculated to reveal the correlation between Ki-67 with parameters. By using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve, each parameter was compared. Results: The ADC, D and f values of high Ki-67 group were all lower than those of low Ki-67 group [(10.89±0.89) × 10−2 mm2/s vs. (14.65±0.46)× 10−2 mm2/s, (9.95±0.92) × 10−2 mm2/s vs. (12.48±0.83) × 10−2 mm2/s, (2.30±0.51) × 10−2 mm2/s vs. (3.75±0.85) × 10−2 mm2/s, all P < 0.05]. Except for D*, ADC, D and f were negatively correlated with the expression of Ki-67 (r = −0.725, −0.733, -0.666, all P < 0.05). The areas under the curve (AUC) of ADC, D and f were 0.901, 0.923 and 0.657 respectively (Table 5). The difference of AUC value between ADC and D was not statistically significant (AUCD = 0.923 vs. AUCADC= 0.901, Z=0.290, P=0.772). The difference of AUC value between ADC and f was statistically significant (AUCADC= 0.901 vs. AUCf= 0.657, Z=2.329, P=0.025). The difference of AUC value between D and f was statistically significant (AUCD= 0.923 vs. AUCf= 0.657, Z=2.124, P=0.034) (Table 6).Conclusions: DWI and IVIM can effectively reflect the proliferative characteristics of gastric adenocarcinoma. D and ADC have higher diagnostic efficiency than f.

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Correlation Between Quantitative Perfusion Histogram Parameters of DCE-MRI and PTEN, P-Akt and m-TOR in Different Pathological Types of Lung Cancer

Cited by 2 publications

References 22 publications

Correlation between apparent diffusion coefficient and Ki-67 in different pathological types of lung cancer

Correlation between apparent diffusion coefficient and Ki-67 in different pathological types of lung cancer

Correlations between Diffusion-Weighted and Intravoxel Incoherent Motion Parameters with Ki-67 Index in Gastric Adenocarcinoma

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