Correlation between protein kinase catalytic subunit alpha-1 gene rs13361707 polymorphism and gastric cancer susceptibility in asian populations

Abstract

A single nucleotide polymorphism (SNP) of the protein kinase catalytic subunit alpha-1 gene (PRKAA1) that confers susceptibility to gastric cancer (GC) was identified by genome-wide association in several case-control studies. However, the results remained controversial and ambiguous. Therefore, we performed a larger meta-analysis to confirm this association. We searched the PubMed, Embase, WanFang, and CNKI databases, without any restriction on language, covering all papers published until Feb 22, 2017. Overall, 14 case-control studies with 14,485 cases and 14,792 controls were retrieved based on the search criteria. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to quantify the strength of the association. Publication bias was assessed by Egger’s and Begg’s tests. We found that the PRKAA1 rs13361707 C/T polymorphism had no association with GC risk in any of the pooled genetic models (for example, the T-allele vs. C-allele allelic contrast model yielded the following estimates: OR = 0.87, 95% CI = 0.73–1.05, Pheterogeneity = 0.000). Furthermore, in analyses stratified by either source of control or geographical origin of subjects, a statistically significant inverse relationship was detected between PRKAA1 rs13361707 C/T polymorphism and GC risk. No obvious evidence of publication bias was detected in the pooled meta-analysis. Furthermore, we observed that individuals carrying T-allele (TT or TC) genotypes had a lower expression of PRKAA1. Our present study indicated that PRKAA1 rs13361707 C/T was not significantly associated with GC risk, despite few positive results in the subgroups.

PRKAA1 rs13361707 C/T polymorphism confers decreased susceptibility to esophageal cancer: A case‐control study

“…20 However, a recent meta-analysis combining all included studies showed no relationship between this SNP and GC risk in Asians. 21 breast cancer risk. 22 Another study implied rs13361707 C/T polymorphism was unrelated to lung cancer risk.…”

“…A study from Europe with mixed Caucasian populations obtained negative results for the association between this SNP and GC risk 20 . However, a recent meta‐analysis combining all included studies showed no relationship between this SNP and GC risk in Asians 21 . A study of 1340 breast cancer cases and 2536 controls in Caucasians obtained no association between this polymorphism and breast cancer risk 22 .…”

An updated association between TNF-α -238G/A polymorphism and gastric cancer susceptibility in East Asians

“…Meta-analyses have been recognized as an effective method to summarize and review previously published quantitative research to answer a wide variety of clinical questions [55]. However, several limitations in our meta-analysis should be acknowledged.…”

TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer

“…Our study also revealed an association between TLR1 rs4833095 and GC, but we did not find the association of this SNP with a susceptibility to H. pylori infection or presence of AG. PRKAA1 rs13361707 has been evaluated in several GC genetic association studies [16,21,[24][25][26][27][42][43][44][45][46][47], following identification of this SNP as a risk factor for non-cardia GC in GWAS in 2011 [22]. The systematic review and meta-analysis by Mocellin et al (2015) supported the link between PRKAA1 rs13361707 and an increased risk of noncardia subtype GC [46].…”

“…Moreover, one study found that PRKAA1 polymorphisms may have an influence to H. pylori infection development and a synergetic effect on the risk of development of GC [26]. However, the direction of this association remains ambiguous and the polymorphism may even be inversely related to GC risk [27].…”