Correlation between Pre-Operative 25-Hydroxyvitamin D Levels and Poor Prognostic Factors for Papillary Thyroid Cancer

Abuduwaili, Munire; Xing, Zhichao; Xia, Baoying; Yuan, Fangyan; Zhu, Jingqiang; Su, Anping

doi:10.1080/08941939.2021.2010842

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…Abuduwaili et al evaluated retrospectively the inverse relationship between pre-operative vitamin D levels and poor prognostic factors for PTC in a large series of patients (n=1,161) and found a statistical significance concerning larger tumor diameter (P=0.049) and occurrence of lymph node metastasis (P=0.00) ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Relationships between serum levels of vitamins and papillary thyroid cancer: a single center case-control study

Zhang¹,

Sun²,

Kim³

et al. 2023

Gland Surg

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Background Vitamins are involved in various human physiological and biochemical mechanisms due to their antioxidant properties and their ability to enhance the immune response. Deficiency of some serum vitamins has been reported to be associated with an increased risk of developing cancer, including thyroid cancer. However, medical literature dealing with cholecalciferol supplementation was not able to show the potential of this intervention in cancer prevention. The aim of this paper is to highlight the association between lower serum vitamins levels and papillary thyroid cancer occurrence. Methods This case-control study was conducted between September 2018 and October 2019. Cases were defined as patients with histologically diagnosed papillary thyroid cancer who underwent thyroidectomy were retrospectively recruited and serum levels of various vitamins were assessed by examining their relationships with clinical, pathological and molecular data (n=51). Controls matched on sex and thyroid surgery were randomly selected from the same population (n=49). Results In this study, serum concentrations of vitamins A and E in neoplastic patients were significantly lower than in controls (1.40 vs. 1.78, P<0.003 and 23.9 vs. 29.1, P<0.003, respectively). Serum concentrations of vitamin D and methylmalonic acid were borderline significantly low (15.6 vs. 17.9, P=0.06 and 100.3 vs. 110.4, P=0.055, respectively), while homocysteine was statistically similar in the two groups. Furthermore, serum vitamin levels were compared with the pathological characteristics of cancer patients, and vitamin D concentrations were significantly lower in BRAF-positive than in BRAF-negative neoplastic patients (8.2 vs. 16.0, P=0.021). On the other hand, no significant differences were observed in the correlation between serum levels of vitamins and other pathological characteristics, in particular with regard to lymph node metastases. Conclusions In conclusion, albeit with the analysis of a limited sample, this study highlighted the phenomenon that deficiencies in vitamins A and E can be associated with a higher frequency of occurrence of papillary thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

Relationships between serum levels of vitamins and papillary thyroid cancer: a single center case-control study

Zhang¹,

Sun²,

Kim³

et al. 2023

Gland Surg

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“…29 Some of the articles linked low VIT D levels with advanced thyroid malignancy. 9,28,30,31 In contrast, one study on papillary TC patients found that patients with TC have higher levels of serum VIT D. 33 The variability of results relating to VIT D levels and TC in different papers can be attributed to several factors, including variations in de nitions of low VIT D levels, units of measurement, and methods of measurement. 30 The timing of pre-operative serum VIT D sampling may also have resulted in a variety of results.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Pre-Operative Vitamin D Serum Levels in Thyroid Cancer Patients

Alsalem

Alnasser

Althanian

et al. 2023

Preprint

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Objective To investigate the relationship between vitamin D levels and thyroid cancer (TC) incidence and the effect of pre-operative vitamin D supplementation. Methods This retrospective case-control study was conducted on patients who underwent thyroidectomy at King Abdulaziz Medical City from January 2016 to January 2022. Their pre-operative vitamin D serum levels and histopathology of resected thyroid nodule (TN) were evaluated. Multivariable conditional logistic regression was computed to determine the relationship between serum 25(OH) D level and TC. Results A total of 633 patients were included in the study, with 325 malignant TN cases and 308 benign TN cases as control. TC group had significantly higher serum 25(OH) D levels than the controls (51.12 nmol/L vs. 46.17 nmol/L, p-value = 0.037). However, there was no significant difference between the groups on serum 25(OH) D level, once categorised into deficient, inadequate, normal, or high. Patients on Vitamin D supplements had a lower incidence of TC (45.5%) than those not on Vitamin D supplements (57.5%), with a significant (p-value = 0.003). In multivariable regression models, patients who took Vitamin D supplements had a 37% lower risk of having TC than those who did not (OR = 0.634; 95% CI = 0.460–0.873). Conclusion There was no significant correlation between Vitamin D deficiency and TC. However, patients on Vitamin D supplements had a lower risk of developing TC than those who had not. Further prospective studies are necessary to clarify the function of this factor.

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“…Two recent meta-analyses by Hu et al and Zhao et al concluded that 25(OH)D deficiency is associated with a higher thyroid cancer risk, and patients with such a diagnosis are observed to have a significantly lower 25(OH)D concentration [ 13 , 14 ]. Some researchers confirmed the correlation between the vitamin D level and selected clinical features of thyroid cancer, the stage of the disease, or prognosis [ 15 , 16 , 17 ]. Zhang et al found that active vitamin D metabolites reduce proliferation and induce apoptosis of PTC cells [ 18 ].…”

Section: Introductionmentioning

confidence: 98%

Vitamin D-Related Genes and Thyroid Cancer—A Systematic Review

Maciejewski

Łącka

2022

IJMS

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Vitamin D, formerly known for its role in calcium-phosphorus homeostasis, was shown to exert a broad influence on immunity and on differentiation and proliferation processes in the last few years. In the field of endocrinology, there is proof of the potential role of vitamin D and vitamin D-related genes in the pathogenesis of thyroid cancer—the most prevalent endocrine malignancy. Therefore, the study aimed to systematically review the publications on the association between vitamin D-related gene variants (polymorphisms, mutations, etc.) and thyroid cancer. PubMed, EMBASE, Scopus, and Web of Science electronic databases were searched for relevant studies. A total of ten studies were found that met the inclusion criteria. Six vitamin D-related genes were analyzed (VDR—vitamin D receptor, CYP2R1—cytochrome P450 family 2 subfamily R member 1, CYP24A1—cytochrome P450 family 24 subfamily A member 1, CYP27B1—cytochrome P450 family 27 subfamily B member 1, DHCR7—7-dehydrocholesterol reductase and CUBN—cubilin). Moreover, a meta-analysis was conducted to summarize the data from the studies on VDR polymorphisms (rs2228570/FokI, rs1544410/BsmI, rs7975232/ApaI and rs731236/TaqI). Some associations between thyroid cancer risk (VDR, CYP24A1, DHCR7) or the clinical course of the disease (VDR) and vitamin D-related gene polymorphisms were described in the literature. However, these results seem inconclusive and need validation. A meta-analysis of the five studies of common VDR polymorphisms did not confirm their association with increased susceptibility to differentiated thyroid cancer. Further efforts are necessary to improve our understanding of thyroid cancer pathogenesis and implement targeted therapies for refractory cases.

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Correlation between Pre-Operative 25-Hydroxyvitamin D Levels and Poor Prognostic Factors for Papillary Thyroid Cancer

Cited by 4 publications

References 33 publications

Relationships between serum levels of vitamins and papillary thyroid cancer: a single center case-control study

Relationships between serum levels of vitamins and papillary thyroid cancer: a single center case-control study

Assessment of Pre-Operative Vitamin D Serum Levels in Thyroid Cancer Patients

Vitamin D-Related Genes and Thyroid Cancer—A Systematic Review

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