Correlation Between Platelet Count and Both Liver Fibrosis and Spleen Diameter in Patients With Schistosomiasis Mansoni

Abstract

-Context -Studies have described the correlation between platelet count and the stages of fibrosis in chronic viral hepatitis, but few publications have studied this correlation in Schistosomiasis mansoni. Objective -Therefore, this study aimed to correlate platelet count with both the periportal fibrosis pattern and spleen diameter evaluated by ultrasound exam in patients with Schistosomiasis mansoni. Methods -Patients with Schistosomiasis mansoni were evaluated by abdominal ultrasound by a single examiner for the determination of periportal fibrosis pattern (Niamey classification) and spleen diameter. Platelet counts were performed in an automated cell counter. Results -One hundred eighty-seven patients with Schistosomiasis mansoni (mean age: 50.2 years) were included in the study, 114 of whom (61%) were women. Based on the Niamey classification, the ultrasound analysis revealed that 37, 64, 64 and 22 patients exhibited patterns C, D, E and F, respectively. In these four groups, the mean number of platelets was 264, 196, 127 and 103 x 10 9 /L and mean spleen diameter was 9.2, 11.9, 14.9 and 16.2 centimeters, respectively. A reduction in platelet count was significantly associated with both the progression of the periportal fibrosis and the increase in spleen size. Conclusion -Platelet count in patients with Schistosomiasis mansoni was inversely correlated with the severity of periportal fibrosis and spleen diameter. HEADINGS -Liver fibrosis. Platelet count. Splenomegaly. Thrombocytopenia. Portal hypertension. Schistosomiasis mansoni.

Schistosoma mansoni-related periportal fibrosis; can we use APRI and PSDR levels in the real-time selection of patients for targeted endoscopy in a resource-limited setting? A case-control study

“…This correlation suggests that varices develop in advanced PPF which in turn is associated with liver dysfunction and reduced thrombocyte count [35][36][37]. In the current study, we similarly observed a signi cant proportion of patients with elevated serum aspartate aminotransferase levels (ALT) and thrombocytopenia as summarized in table 1.…”

Schistosoma mansoni -related periportal fibrosis; are APRI and PSDR levels of any potential utility in a well-timed selection of patients for targeted endoscopy in a resource-limited setting?: a case-control clinic-based study

“…The current finding that the portal varices in patients with PPF were independently common in patients with higher median APRI levels suggest that APRI levels can be used to select patients at high risk of having varices in areas with limited services. This correlation suggests that varices develop in advanced PPF which in turn is associated with liver dysfunction and reduced thrombocyte count [35][36][37]. In the current study, we similarly observed a significant proportion of patients with elevated serum aspartate aminotransferase levels (ALT) and thrombocytopenia as summarized in Table 1.…”

New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni

“…Another study conducted with 122 patients with schistosomiasis showed a significant negative correlation with the different patterns of PPF. The more advanced stages of fibrosis were associated with lower platelet count compared to the group of patients without fibrosis (23) . The Coutinho-index presented in this study showed significant accuracy (AUC=1.000) since it distinguished schistosomiasis patients without advanced fibrosis from those with advanced fibrosis.…”