Correlation between pharmacologically-induced changes in cystometric parameters and spinal c-Fos expression in rats

Nagabukuro, Hiroshi; Degenhardt, Amanda; Villa, Katherine L.; Mistry, Shruti; Gichuru, Loise; Jochnowitz, Nina; Abbadie, Catherine

doi:10.1016/j.autneu.2010.02.006

Cited by 10 publications

(13 citation statements)

References 32 publications

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“…This pattern was very similar to results in resiniferatoxin‐treated rats . While the mechanism of the beta‐3 AR agonist treatments are different from the resiniferatoxin treatments, a common feature of the two is the increase of urine storage. Thus, the partial reduction in the cold stress‐induced detrusor overactivity might be caused by the relaxation of the urinary detrusor promoted by CL316243.…”

Section: Discussionsupporting

confidence: 79%

Pathways Involving Beta‐3 Adrenergic Receptors Modulate Cold Stress‐Induced Detrusor Overactivity in Conscious Rats

Imamura

Ishizuka

Ogawa

et al. 2014

LUTS

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Section: Discussionsupporting

confidence: 79%

Pathways Involving Beta‐3 Adrenergic Receptors Modulate Cold Stress‐Induced Detrusor Overactivity in Conscious Rats

Imamura

Ishizuka

Ogawa

et al. 2014

LUTS

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“…Moreover, acute intraventricular and intrathecal administration of tamulosin, significantly inhibited reflex voiding in the normal rat [54] and chronic systemic treatment with two different a1-AR antagonists-inhibited reflex voiding in a rat model of BOO [55]. A recent experimental study by Nagabukuro et al [56] investigated changes in afferent firing following treatment with a number of commonly used clinical drugs. The study found that tamulosin treatment significantly attenuated activation of the early gene c-fos, commonly used as a marker for sensory neuronal activation, in the spinal cord.…”

Section: Adrenoreceptorsmentioning

confidence: 96%

The afferent system and its role in lower urinary tract dysfunction

Daly

Collins

Chapple

et al. 2011

Current Opinion in Urology

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Recent studies provide further evidence that afferent control of the bladder may be dependent on integration of excitatory and inhibitory mediators from the urothelium such as ATP and nitric oxide. A number of studies have examined the role cholinergic and adrenergic mechanisms play in bladder afferent function, and several new potential mechanisms involving the cannabinoid receptors and transient receptor potential channels have emerged as areas which warrant further investigation. A better understanding of afferent mechanisms in the bladder will hopefully lead to more effective treatments of lower urinary tract disorders.

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“…Cystometry was performed as described previously (Nagabukuro et al, 2010). In brief, animals were anes-…”

Section: Methodsmentioning

confidence: 99%

“…Two other studies also showed a bladder capacity increase with atropine in either conscious or anesthetized rhesus monkeys (Craggs and Stephenson, 1985;Shoukry and Ghoniem, 1992). In contrast, many studies using either normal healthy or diseased rodent models did not show any bladder capacity increase with antimuscarinics or showed an increase only at the high doses (Sasaki et al, 1997;Angelico et al, 2005;Ohtake et al, 2007;Hegde et al, 2009;Nagabukuro et al, 2010), which were much higher than therapeutic doses. Only in certain disease models, such as cerebral infarction, did antimuscarinics, including tolterodine and solifenacin, increase bladder capacity at reasonable doses from clinical use of these drugs (Suzuki et al, 2005).…”

mentioning

confidence: 96%

“…In addition, in healthy subjects, tolterodine increased the bladder volume, evoking the normal desire to void (Stahl et al, 1995). In contrast, many studies in rats, the most frequently used preclinical species, failed to show an increase in bladder capacity with antimuscarinics (Sasaki et al, 1997;Angelico et al, 2005;Nagabukuro et al, 2010) or showed a bladder capacity increase only at the high doses (Ohtake et al, 2007;Hegde et al, 2009). Despite this paradox, these studies successfully demonstrated the inhibitory effects of antimuscarinics on detrusor contractility by demonstrating a significant decrease in the maximal micturition pressure and a significant increase in the residual urine volume.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Analysis of the Effects of Antimuscarinic Agents on Bladder Functions in Both Nonhuman Primates and Rodents

Nagabukuro¹,

Villa²,

Wickham³

et al. 2011

J Pharmacol Exp Ther

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Both the physiological role of muscarinic receptors for bladder function and the therapeutic efficacy of antimuscarinic agents for overactive bladder syndrome are well documented. We investigated the effect of antimuscarinic agents with different subtype selectivity on urodynamic parameters in nonhuman primates and rodents and compared plasma levels of these agents between species. Anesthetized rhesus monkeys were transurethrally catheterized, and the bladder was infused with saline. Urodynamic parameters were measured before and after intravenous drug administration. Tolterodine (nonselective) and oxybutynin (moderately M 3 -selective) increased bladder capacity at lower doses than those required to decrease micturition pressure. However, higher doses of darifenacin (M 3 -selective) were needed to increase the bladder capacity than those needed to decrease the micturition pressure. In rats, tolterodine had no effect on the bladder capacity but decreased the micturition pressure at all of the doses administered. Oxybutynin also decreased micturition pressure and increased bladder capacity at the highest dose. Plasma levels of these drugs overlap in both species. These results suggest that, in addition to the M 3 receptor, other muscarinic receptor subtypes contribute to regulate bladder storage function in nonhuman primates, since less subtype-selective tolterodine and oxybutynin showed higher specificity to the bladder capacity effect than the effect on micturition pressure compared with M 3 -selective darifenacin. In addition, the role of muscarinic receptors in bladder storage function varies between primates and rodents. Compared with rodents, muscarinic receptors may play a more active role during the storage phase to regulate the functional bladder capacity in primates.

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Correlation between pharmacologically-induced changes in cystometric parameters and spinal c-Fos expression in rats

Cited by 10 publications

References 32 publications

Pathways Involving Beta‐3 Adrenergic Receptors Modulate Cold Stress‐Induced Detrusor Overactivity in Conscious Rats

Pathways Involving Beta‐3 Adrenergic Receptors Modulate Cold Stress‐Induced Detrusor Overactivity in Conscious Rats

The afferent system and its role in lower urinary tract dysfunction

Comparative Analysis of the Effects of Antimuscarinic Agents on Bladder Functions in Both Nonhuman Primates and Rodents

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