Correlation between Parturients’ Uterine Artery Blood Flow Spectra in the First and Second Trimesters of Pregnancy and Fetal Growth Restriction

Yu, Hongna; Ma, Yuan; Li, Xia; Jiang, Meiping

doi:10.1155/2021/2129201

Cited by 4 publications

(2 citation statements)

References 24 publications

(24 reference statements)

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“…Pulsatility index (PI), resistivity index (RI), and the systolic-diastolic ratio (S/D) were recorded. The changes of PI, RI, and fp of IVIM was evaluated with the cut-off values from receiver operating characteristic (ROC) curves and area under the curve (AUC) analysis as previous described ( 9 , 14 ).…”

Section: Methodsmentioning

confidence: 99%

Risk Factors for Short Stature in Children Born Small for Gestational Age at Full-Term

et al. 2022

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ObjectiveThis study aims to identify the risk factors associated with short stature in children born small for gestational age (SGA) at full-term.MethodsThis was a retrospective study. The subjects were full-term SGA infants who were followed up until the age of 2 years. The risk factors for short stature were identified with univariate and multivariate analyses.ResultsOf 456 full-term SGA children enrolled in this study, 28 cases had short stature at 2 years of age. A significant decrease in placental perfusion was found in the short children group with intravoxel incoherent motion (IVIM) technology, which was an advanced bi-exponential diffusion-weighted imaging (DWI) model of magnetic resonance imaging (MRI) (p = 0.012). Compared to non-short children born SGA at full-term, the short children group underwent an incomplete catch-up growth. Mothers who suffered from systemic lupus erythematosus were more likely to have a short child born SGA (p = 0.023). The morbidity of giant placental chorioangioma was higher in the short children group. The pulsatility index (PI), resistivity index (RI), and systolic-diastolic (S/D) ratio of umbilical artery were higher in the short children group than in the non-short control group (p = 0.042, 0.041, and 0.043). Multivariate analysis demonstrated that decrease of perfusion fraction (fp) in IVIM of placental MRI, chromosomal abnormalities, short parental height, and absence of catch-up growth were associated with a higher risk of short stature in children born SGA at full-term.ConclusionRisk factors for short stature in full-term SGA children at 2 years of age included a decrease of perfusion fraction fp in IVIM of placental MRI, chromosomal abnormalities, and short parental height.

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Section: Methodsmentioning

confidence: 99%

Risk Factors for Short Stature in Children Born Small for Gestational Age at Full-Term

et al. 2022

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“…Placental insufficiency is considered to be the main cause of FGR 5,6 , and is associated with abnormalities in biomarkers such as placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) 7 , as well as abnormal hemodynamics, such as uterine artery (UtA) pulsatility index (PI) 8 . The ductus venosus (DV) connects the umbilical vein to the fetal inferior vena cava, and plays a crucial role in fetal growth and development.…”

Section: Introductionmentioning

confidence: 99%

Construction of prediction model for fetal growth restriction during first trimester in an Asian population

Zheng,

Ji,

Wang

et al. 2024

Ultrasound in Obstet & Gyne

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ObjectiveTo construct a prediction model for fetal growth restriction (FGR) during the first trimester (11‐13+6 weeks) and evaluate its screening performance.MethodsSingle pregnancies who underwent the first trimester (11‐13+6 weeks) ultrasound screening at the Affiliated Suzhou Hospital of Nanjing Medical University from January 2019 to April 2022 were selected as prospective study subjects. Basic clinical information, ultrasound indicators, and serum indicators of pregnant women were collected. Fetal weight assessment was based on the fetal growth curve of the Southern Chinese population, and the definition of FGR was based on standards developed through the Delphi process. The least absolute shrinkage and selection operator (LASSO) regression method was used to select optimal features and analyze the predictive value of each indicator in the model. Finally, the model was constructed, and its discrimination, effectiveness, and clinical usefulness were evaluated.ResultsA total of 1188 pregnant women were included in the final statistical analysis, of whom 108 had FGR. LASSO regression identified 7 predictive features, including a history of maternal hypertension, maternal smoking or passive smoking history, number of pregnancies, uterine artery pulsatility index (UtA PI), ductus venosus pulsatility index (DV PIV), placental growth factor multiples of the median (PlGF MOM), and soluble fms‐like tyrosine kinase‐1 (sFlt‐1) MOM. The nomogram prediction model constructed based on the above predictors predicted FGR more accurately, and the area under the curve (AUC) in the validation cohort was 0.82 (95%CI: 0.74‐0.90). The calibration curve and Hosmer‐Lemeshow test demonstrated good calibration of the model, while the clinical decision curve and clinical impact curve conclusively support its practical value in the clinical setting.ConclusionThe multi‐index prediction model constructed during the first trimester is feasible and has good predictive value.This article is protected by copyright. All rights reserved.

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Low‐dose aspirin improves blood perfusion of obstetric anticardiolipin syndrome in China

Cao,

Zhou,

et al. 2024

Intl J Gynecology & Obste

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ObjectiveThis study evaluates the endometrial receptivity of obstetric anticardiolipin syndrome (OAPS) patients using various ultrasound indicators and the efficacy of low‐dose aspirin (LDA) treatment.MethodsThis retrospective study recruited patients from Shanghai Ren Ji Hospital, China from January 2022 to December 2023. Doppler parameters of the endometrium and uterine artery blood flow were recorded to assess the endometrial receptivity of OAPS patients compared with normal pregnant women and an other immune diseases group. The receiver operating characteristic curve was used to predict the risk of OAPS patients. Doppler parameters of OAPS patients were conducted repeatedly after a 2‐month period of treatment with LDA.ResultsCompared with normal pregnant women, the OAPS group showed remarkably increased endometrial perfusion resistance (PI, RI, S/D) and uterine artery perfusion resistance (RI and S/D) (P < 0.001) and had good predictive values (area under the curve = 0.806, 0.976, 0.942, 0.902, and 0.901, respectively). The endometrial thickness of the OAPS group was much thinner than that of the normal group (P < 0.001). Uterine blood flow impedance PI showed no difference in both groups (P = 0.68). In comparison to other autoimmune diseases, the OAPS group also showed an increasing trend in the resistance of endometrium and uterine artery blood flow. After LDA treatment, there was an obvious improvement in the endometrial blood flow perfusion in the OAPS group (P < 0.01).ConclusionCompared with the normal group and other autoimmune diseases, the resistance of endometrial and uterine artery blood flow in the OAPS group was increased significantly. The Doppler index showed the predictive value of OAPS, and it was confirmed that LDA could enhance blood perfusion among OAPS women.

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Correlation between Parturients’ Uterine Artery Blood Flow Spectra in the First and Second Trimesters of Pregnancy and Fetal Growth Restriction

Cited by 4 publications

References 24 publications

Risk Factors for Short Stature in Children Born Small for Gestational Age at Full-Term

Risk Factors for Short Stature in Children Born Small for Gestational Age at Full-Term

Construction of prediction model for fetal growth restriction during first trimester in an Asian population

Low‐dose aspirin improves blood perfusion of obstetric anticardiolipin syndrome in China

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