Correlation between p53 expression and clinical-pathological characteristics of gastric cancer

Radovanovic, Dragce; Knežević, Milan; Čanović, Dragan; Aćimović, Ljubiša

doi:10.2298/vsp1110832r

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Upon future verification, detection of CAII protein expression may help clinicians develop a more aggressive treatment for aggressive pancreatic cancer. In our study, p53 overexpression was associated with TNM stage and lymph node metastasis, but was not associated with patient prognosis, which was consistent with the studies in gastric and pancreatic cancer 11, 12, 24, 25.…”

Section: Discussionsupporting

confidence: 92%

Down regulation of CAII is associated with tumor differentiation and poor prognosis in patients with pancreatic cancer

Sheng

Dong

Zhou

et al. 2012

Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 92%

Down regulation of CAII is associated with tumor differentiation and poor prognosis in patients with pancreatic cancer

Sheng

Dong

Zhou

et al. 2012

Journal of Surgical Oncology

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“…Interestingly, in this study, the elderly patients had a tendency towards p53 overexpression, which is known to be related to vascular invasion, as well as carcinogenesis ( 19 ). Other than this profile, gastric cancer in elderly patients showed pathologic features related to favorable prognosis.…”

Section: Discussionmentioning

confidence: 65%

Clinicopathological Features and Surgical Safety of Gastric Cancer in Elderly Patients

et al. 2014

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Gastric cancer is one of the most common cancers, especially among the elderly. However little is known about gastric cancer in elderly patients. This study was designed to evaluate the specific features of gastric cancer in elderly patients. Medical records of 1,107 patients who had radical gastrectomy for gastric cancer between June 2005 and December 2009 were reviewed. They were divided into young (<65 yr, n=676), young-old (65-74 yr, n=332), and old-old age group (≥75 yr, n=99). Increased CA 19-9 (5.6%, 13.4%, 14.6%, P=0.001), advanced diseases (42.5%, 47.0%, and 57.6, P=0.014), and node metastasis (37.6%, 38.9%, 51.5%, P=0.029) were more common in the young-old and old-old age groups. There were no significant differences in Helicobacter pylori status (63.6%, 56.7%, 61.2%, P=0.324) between the three groups. Surgery-related complication rates were similar in the three groups (5.3%, 5.1%, 8.1%, P=0.497). Microsatellite instability (P<0.001) and p53 overexpression (P<0.001) were more common among the elderly. The elderly group had more synchronous tumors (7.5%, 10.2%, 17.2%; P=0.006). Surgery can be applied to elderly gastric cancer without significant risk of complications. However, considering the more advanced disease and synchronous tumors among the elderly, care should be taken while deciding the extent of surgery for elderly gastric cancer.Graphical Abstract

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Cancer Stem Cells Biomarkers in Gastric Carcinogenesis

Liu

Levi

Zhu

et al. 2013

J Gastrointest Canc

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Correlation between p53 expression and clinical-pathological characteristics of gastric cancer

Abstract: There is a direct correlation between p53 expression and gastric cancer and it indicates the ability of carcinoma cells to invade blood vessels.

Cited by 4 publications

References 27 publications

Down regulation of CAII is associated with tumor differentiation and poor prognosis in patients with pancreatic cancer

Down regulation of CAII is associated with tumor differentiation and poor prognosis in patients with pancreatic cancer

Clinicopathological Features and Surgical Safety of Gastric Cancer in Elderly Patients

Cancer Stem Cells Biomarkers in Gastric Carcinogenesis

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