Correlation between optic disc atrophy and aetiology: anterior ischaemic optic neuropathy vs optic neuritis

Rath, Eitan Z.; Rehany, Uri; Linn, Shai; Rumelt, Shimon

doi:10.1038/sj.eye.6700691

Cited by 30 publications

(23 citation statements)

References 13 publications

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“…As a result, the cup parameters were not different between the two groups, indicating that acquired excavation did not take place in the eyes with NAION. These findings were inconsistent with a previous study by Rath et al, 14 where the C/D ratio was 1.1-to 1.2-fold larger in NAION discs compared with uninvolved fellow discs under the slit-lamp examination with a þ 90 D non-contact lens. However, the subjective assessment of the ONH by funduscopy does not readily distinguish the border of cupping from pale rim of the atrophic disc, which may have possibly led to the marginal overestimation of the cupping in their study.…”

Section: Hrt Parameters In Optic Neuropathiescontrasting

confidence: 99%

Evaluation of optic nerve head configuration in various types of optic neuropathy with Heidelberg Retina Tomograph

Nagai-Kusuhara

Nakamura

Kanamori

et al. 2007

Eye

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Purpose To test whether Heidelberg Retina Tomograph (HRT) is applicable to assess the optic nerve head (ONH) configuration of the atrophic phase of non-glaucomatous optic neuropathy when a default set of the reference plane is used. Methods Ten eyes with non-arteritic anterior ischaemic optic neuropathy (NAION), 17 eyes with Leber's hereditary optic neuropathy (LHON), 40 eyes with compressive optic neuropathy (CON) owing to chiasmal tumour, and 241 eyes of control individuals were examined with HRT using the default reference plane. The global values of HRT parameters were evaluated among the groups of patients and controls. The sectoral measurements of the eyes with LHON and CON were compared with controls. To eliminate the influence of disc size and age on HRT measurements, eyes with disc area-and age-matched normal controls were used for comparison with eyes with NAION and LHON. Results Cup parameters in eyes with NAION were similar to those in controls. The retinal nerve fibre layer (RNFL) thickness was significantly thinner in eyes with NAION than that of controls. The eyes with LHON had significantly larger cup parameters, smaller rim volume, and thinner mean RNFL thickness than controls. Eyes with CON had significantly larger rim area and smaller cup parameters but similar RNFL thickness compared with controls. Conclusions When the default reference plane is used, HRT can measure the ONH configuration in eyes with NAION and LHON as expected. However, caution must be made to interpret the parameters obtained from the eyes with CON.

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Section: Hrt Parameters In Optic Neuropathiescontrasting

confidence: 99%

Evaluation of optic nerve head configuration in various types of optic neuropathy with Heidelberg Retina Tomograph

Nagai-Kusuhara

Nakamura

Kanamori

et al. 2007

Eye

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“…The acquired type of optic atrophy may be caused by different pathologic damages to the optic nerve, such as the optic neuritis (ON), the ischemic optic neuropathy, or advanced glaucoma [1,28]. ON, the most prevalent optic neuropathy in otherwise healthy young adults, causes alterations in visual acuity, pupillary symmetry, and visual field [6,18].…”

Section: Introductionmentioning

confidence: 99%

Measurement of retinal nerve fiber layer thickness in optic atrophy eyes of patients with optic neuritis using optical coherence tomography

Wang

Xia

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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“…[1][2][3][4][5][6][7] Although traditionally it has been accepted that the most common change in the optic nerve head (ONH) after optic neuritis is optic disc pallor, previous studies using optic disc photography have found that patients with optic neuritis have a larger cup in the affected eye compared with the fellow eye. 8,9 Rath et al 8 described an increase in the cup-to-disc (C/D) ratio of 0.1-0.2 in the affected eye compared with the fellow eye; it was also greater than in a group of age-matched control subjects. In contrast, Radius and Maumenee 10 found no significant increase in optic disc cupping.…”

Section: Introductionmentioning

confidence: 99%

Optic disc cupping after optic neuritis evaluated with optic coherence tomography

Rebolleda

Noval

Contreras

et al. 2008

Eye

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Purpose To determine whether the optic disc experiences cupping after an episode of optic neuritis as assessed by optical coherence tomography (OCT). Methods A total of 50 patients with unilateral optic neuritis and 50 age-and sex-matched controls were studied. A complete examination, including visual acuity (VA), visual fields, and OCT scanning of the optic nerve head was performed. Mean cup-to-disc (C/D) ratios in the affected eyes were compared with fellow and control eyes. Results Mean C/D area ratio (CDAR), C/D vertical ratio (CDVR), and C/D horizontal ratio (CDHR) were significantly larger in the affected eyes compared to fellow (Po0.001) and control eyes (Po0.05). The asymmetry in CDAR, CDVR, and CDHR between both eyes in the patients with optic neuritis was equal to or greater than 0.2 in 24, 28, and 30% respectively. A significant inverse correlation was found between the C/D ratios asymmetry and retinal nerve fibre layer (RNFL) thickness (Po0.05). Conclusion A significant increase in C/D ratio can be detected by OCT after unilateral optic neuritis, inversely correlated with RNFL thickness, and VA.

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Correlation between optic disc atrophy and aetiology: anterior ischaemic optic neuropathy vs optic neuritis

Cited by 30 publications

References 13 publications

Evaluation of optic nerve head configuration in various types of optic neuropathy with Heidelberg Retina Tomograph

Evaluation of optic nerve head configuration in various types of optic neuropathy with Heidelberg Retina Tomograph

Measurement of retinal nerve fiber layer thickness in optic atrophy eyes of patients with optic neuritis using optical coherence tomography

Optic disc cupping after optic neuritis evaluated with optic coherence tomography

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