Correlation between obesity and clinicopathological factors in patients with papillary thyroid cancer

Kim, Shin-Hyuk; Park, Hyung Seok; Kim, Kiho; Yoo, Ho; Chae, Byung Joo; Bae, Ja Seong; Jung, Seung Hye; Song, Byung-Joo

doi:10.1007/s00595-014-0984-3

Cited by 33 publications

(28 citation statements)

References 18 publications

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“…[14–16,18,24] Our study has shown at the first time that higher BMI is strongly associated with extra-thyroidal invasion and universally associated with multifocality, advanced TNM staging, and primary tumor size >1 cm in our study. Further, those had been shown at the same time in the overweight group and/or in the obese group.…”

Section: Discussionsupporting

confidence: 51%

“…[13] Some studies suggested that obesity was significantly associated with larger tumor size and marginally associated with advanced tumor stage. [14,15] At the same time, Kim et al [16] believed that the correlation between the 2 was found in a specific group of patients ≥45 years of age. In Chinese population, Liu et al [17] found that increased BMI might elevate the risks of aggressive clinicopathological features, such as extrathyroidal invasion and advanced TNM stage.…”

Section: Introductionmentioning

confidence: 99%

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Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer

Wang²,

Chen³

et al. 2017

Medicine

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Epidemiological studies suggest that obesity is a risk of thyroid cancer, especially papillary thyroid cancer (PTC). However, the associations of obesity and clinic–pathological features, especially the association of body mass index (BMI) and lymph node metastasis of thyroid cancer are unclear. Seven hundred ninety-six primary patients with PTC were enrolled in this retrospective cohort study. The relationships between BMI and clinic-pathological features of PTC were evaluated by logistic regression models based on the 5-point increase in BMI and BMI quartiles (underweight, normal weight, overweight, and obesity). The 5-point increase in BMI was strongly associated with extra-thyroidal invasion [odds ratio (OR) 2.201, P < 0.001], primary tumor size larger than 1 cm (OR 1.267, P = 0.027), advanced tumor node metastasis (TNM) staging (OR 1.479, P = 0.004), and multifocality (OR 1.31, P = 0.01) in multivariable-adjusted models. The relationships between BMI and lymph node metastasis of PTC were evaluated by Mann–Whitney U test. The mean number of positive central lymph nodes and lateral nodes were increased with the increase of BMI when BMI ≥18.5 kg/m2. It was not shown in underweight group. The present study found that increased BMI was associated with the lymph node metastases (LNMs) of patients with PTC, and other invasive features, including large tumor size, extra-thyroidal invasion, advanced TNM staging, and multifocality. Further studies with long-term follow-up are needed to confirm this finding.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer

Wang²,

Chen³

et al. 2017

Medicine

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“…Some studies have also confirmed an association between obesity and increased risk for thyroid cancer. Obesity may influence tumor size and extrathyroidal invasion, and may increase aggressiveness and metastasis of cancer (Kim et al, 2015;Ma et al, 2015). In agreement with our study, Guignard et al (2007) found no evidence between alcohol consumption and thyroid cancer risk in New Caledonia (Oceania) population.…”

Section: Discussionsupporting

confidence: 88%

Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development

Lopes¹,

Gimenez-Martins²,

Nascimento-Filho³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087) polymorphisms and risk for thyroid and breast cancer. Polymerase chain reaction-restriction fragment length technique was used to determine the specific genotypes in the genes of interest. Statistical analysis was performed by multiple logistic regression test. We found an association between MTHFR C677T polymorphism and risks to both thyroid (OR = 2.50; 95%CI = 1.15-5.46; P = 0.02) and breast cancer (OR = 2.53; 95%CI = 1.08-5.93; P = 0.03). Tobacco consumption and high body mass index were also associated with thyroid cancer. In addition, increased age (≥50 years) and alcohol consumption were found to be associated with breast cancer. Our results indicated that MTHFR C677T is significantly associated with thyroid and breast cancer risks. Thus, these factors may be used as potential prognostic markers for thyroid and breast cancers.

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“… 36 , 37 Previous investigations have suggested that obesity is a potential inducer of PTC tall cell variants, 38 changes in iodine uptakes, more frequent mutations in BRAF (V600E) genes, and the transformation of a normal phenotype to a malignant one in thyroid cells or more aggressive forms of PTC. 38 , 39 More evidence is needed to determine the precise mechanisms of the link between weight change during adulthood and PTC risk, particularly regarding the risk of PTC with a more aggressive tumor presentation.…”

Section: Discussionmentioning

confidence: 99%

Annual Average Changes in Adult Obesity as a Risk Factor for Papillary Thyroid Cancer

et al. 2016

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Correlation between obesity and clinicopathological factors in patients with papillary thyroid cancer

Abstract: In PTC patients ≥45 years of age, a higher BMI was associated with more aggressive tumor features, such as lymph node metastasis, lymphatic invasion, and tumor multiplicity.

Cited by 33 publications

References 18 publications

Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer

Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer

Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development

Annual Average Changes in Adult Obesity as a Risk Factor for Papillary Thyroid Cancer

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