Correlation between number of renal cysts and aortic circumferences measured using autopsy material

Kurata, Atsushi; Inoue, Shigeru; Ohno, Shinya; Nakatsubo, Ryosuke; Takahashi, Kengo; Itô, Tatsuya; Kawasaki, Kenta; Kokubo, Reiji; Sakai, Takashi; Ubukata, Jun; Matsubara, Shuya; Muraoka, Ryu; Yamazaki, Jun; Hirose, Takao; Hojo, Mayuko; Watanabe, Eri; Kuroda, Masahiko

doi:10.1016/j.prp.2013.04.012

Cited by 9 publications

(10 citation statements)

References 23 publications

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“…6–8 In an autopsy study on consecutive cases, it was demonstrated that the number of SRCs had been related with the aortic circumference. 21 Along this line was our study, in which the prevalence of SRCs in patients with AAA was 63% compared with only 45% in aged-matched patients without AAA. All the aforementioned studies come from different geographic latitudes, including Asia, America and Europe, and thus, there is a speculation that no obvious relation with ethnicity should exist.…”

Section: Discussionmentioning

confidence: 69%

The association of simple renal cysts with abdominal aortic aneurysms and their impact on renal function after endovascular aneurysm repair

et al. 2015

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We validated the association of simple renal cysts with abdominal aortic aneurysm and other cardiovascular factors and assessed simple renal cysts' impact on renal function before and after endovascular abdominal aortic aneurysm repair. A retrospective analysis of prospectively collected data was conducted. Computed tomography angiograms of 100 consecutive male patients with abdominal aortic aneurysm who underwent endovascular abdominal aortic aneurysm repair (Group 1) were reviewed and compared with 100 computed tomography angiogram of aged-matched male patients without abdominal aortic aneurysm (Group 2). Patients' demographic data, risk factors, abdominal aortic aneurysm diameter, the presence of simple renal cyst and laboratory tests were recorded. No difference was observed between the two groups in respect to other cardiovascular risk factors except hyperlipidemia with higher prevalence in Group 1 (p < 0.05). Presence of simple renal cysts was independently associated with age (p < 0.05) and abdominal aortic aneurysm (p = 0.0157). There was no correlation between simple renal cysts and abdominal aortic aneurysm size or pre-operative creatinine and urea levels. No difference was observed in post-operative creatinine and urea levels either immediately after endovascular abdominal aortic aneurysm repair or in 12-month follow-up. In male patients, the presence of simple renal cysts is associated with abdominal aortic aneurysm and is increasing with age. However, their presence is neither associated with impaired renal function pre-endovascular abdominal aortic aneurysm repair and post-endovascular abdominal aortic aneurysm repair nor after 12-month follow-up.

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Section: Discussionmentioning

confidence: 69%

The association of simple renal cysts with abdominal aortic aneurysms and their impact on renal function after endovascular aneurysm repair

et al. 2015

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“…Additionally, autosomal dominant polycystic disease is characterized by an increased risk of aneurysm formation. 17 –21…”

Section: Introductionmentioning

confidence: 99%

Presence of Renal Simple Cysts Is Associated With Increased Risk of Abdominal Aortic Aneurysms

Song

Park

2014

Angiology

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We compared the incidence of renal simple cysts in 271 patients with abdominal aortic aneurysm (AAA) and 1387 patients without AAA (controls) using computed tomography (CT) angiography and abdominal CT, as a health screening program. The AAA group had significantly higher prevalence of renal simple cysts (55% vs 19%, P = .001) and chronic obstructive pulmonary disease (COPD; 12% vs 1%, P = .011) than the controls. After propensity score matching (n = 164), the prevalence of renal simple cysts was still significantly higher in the AAA group. In multivariate analysis, independent predictors of AAA were age, male gender, smoking history, hypertension, high-sensitivity C-reactive protein, creatinine, COPD, and renal simple cysts. The structural weakness predisposing for renal simple cysts may be associated with the initiation of AAA formation. More studies are needed to determine whether the presence of renal simple cysts can be considered as a risk factor for AAA.

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“…Molecular studies suggest that MMPs play a role in the pathophysiology of SRC and AAA [33]. Furthermore, one study on 108 autopsies showed a correlation between the diameter of the abdominal aorta and the number of SRC [43]. Further research on kidney diseases and AAA is not only of academic, but also of clinical interest.…”

Section: Discussionmentioning

confidence: 99%

Association of simple renal cysts and chronic kidney disease with large abdominal aortic aneurysm

et al. 2020

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Background: Abdominal aortic aneurysms (AAA) primarily affect men over 65 years old who often have many other diseases, with similar risk factors and pathobiological mechanisms to AAA. The aim of this study was to assess the prevalence of simple renal cysts (SRC), chronic kidney disease (CKD), and other kidney diseases (e.g. nephrolithiasis) among patients presenting with AAA. Methods: Two groups of patients (97 AAA and 100 controls), with and without AAA, from the Surgical Clinic Charité, Berlin, Germany, were selected for the study. The control group consisted of patients who were evaluated for a kidney donation (n = 14) and patients who were evaluated for an early detection of a melanoma recurrence (n = 86). The AAA and control groups were matched for age and sex. Medical records were analyzed and computed tomography scans were reviewed for the presence of SRC and nephrolithiasis. Results: SRC (74% vs. 57%; p<0.016) and CKD (30% vs. 8%; p<0.001) were both more common among AAA than control group patients. On multivariate analysis, CKD, but not SRC, showed a strong association with AAA. Conclusions: Knowledge about pathobiological mechanisms and association between CKD and AAA could provide better diagnostic and therapeutic approaches for these patients.

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Correlation between number of renal cysts and aortic circumferences measured using autopsy material

Cited by 9 publications

References 23 publications

The association of simple renal cysts with abdominal aortic aneurysms and their impact on renal function after endovascular aneurysm repair

The association of simple renal cysts with abdominal aortic aneurysms and their impact on renal function after endovascular aneurysm repair

Presence of Renal Simple Cysts Is Associated With Increased Risk of Abdominal Aortic Aneurysms

Association of simple renal cysts and chronic kidney disease with large abdominal aortic aneurysm

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