Correlation Between Non-Alcoholic Fatty Liver and Chronic Kidney Disease

Kasim, Hasyim; Zatalia, S.R.; Rasyid, Haerani; Bakri, Syakib; Parewangi, Muhammad L.; Akil, Fardah; Seweng, Arifin

doi:10.2174/1874303x02013010001

Cited by 2 publications

(3 citation statements)

References 14 publications

(5 reference statements)

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“…Kasim et al . 35 also found more grade 3 CKD patients in the NAFLD group than in the control group (37.3% vs. 9.0%).…”

Section: Effects Of Nafld On Ckd Severitymentioning

confidence: 71%

“…34 Ramadhan et al 58 found that the presence of liver fibrosis increased the CKD risk by approximately 3.8 times in patients with NAFLD (95% CI: 1.07-13.79, p=0.035); meanwhile, the frequency of grades 2 and 3 CKD was higher in patients with liver fibrosis than in those without (p=0.034). Kasim et al 35 also found more grade 3 CKD patients in the NAFLD group than in the control group (37.3% vs. 9.0%).…”

Section: Effects Of Nafld On Ckd Severitymentioning

confidence: 88%

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Influence of Nonalcoholic Fatty Liver Disease on the Occurrence and Severity of Chronic Kidney Disease

Tao¹,

Li²,

Cheng³

et al. 2021

J Clin Transl Hepatol

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Nonalcoholic fatty liver disease (NAFLD) is reported to affect 20-30% of adults and is accompanied by various metabolic comorbidities, where the economic and clinical burden of NAFLD is attributed to the progression of liver disease as well as the presence of extrahepatic diseases. Chronic kidney disease (CKD), which has a high incidence rate, high morbidity and mortality rates, and high medical costs, has been linked to NAFLD. CKD is associated with some metabolism-related risk factors that overlap with metabolic comorbidities of NAFLD. Therefore, to investigate the potential factors that influence CKD occurrence, the association between NAFLD and CKD should be clarified. Some studies have confirmed that NAFLD influences the occurrence and severity of CKD, whereas some studies have indicated that there is no correlation. In this review, the results of a few studies have been discussed, the potential risk factors for CKD in NAFLD are explored, and the respective biological mechanisms are elaborated to help clinicians identify CKD in patients much earlier than it is diagnosed now and thus help in reducing the incidence of liver and kidney transplants.

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“…Kasim et al . 35 also found more grade 3 CKD patients in the NAFLD group than in the control group (37.3% vs. 9.0%).…”

Section: Effects Of Nafld On Ckd Severitymentioning

confidence: 71%

Section: Effects Of Nafld On Ckd Severitymentioning

confidence: 88%

Influence of Nonalcoholic Fatty Liver Disease on the Occurrence and Severity of Chronic Kidney Disease

Tao¹,

Li²,

Cheng³

et al. 2021

J Clin Transl Hepatol

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“…14 Studies have shown NAFLD as an independent risk factor and contributes to the development of CKD. 15 BMI was also evaluated. It shows that the majority of patients having a mild reduction in GFR or a stage II kidney disease, also had an increased BMI.…”

Section: Discussionmentioning

confidence: 99%

Association of Low GFR and Non-Alcoholic Hepatosteatosis on Fibroscan of Liver

Baqai¹,

Mahmud²,

Anwar

et al. 2023

J Ayub Med Coll Abbottabad

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Background: Chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD) are becoming a health concern, owing to their increasing incidence and prevalence. Both entities are linked to poor outcomes and increased costs, hence greatly impacting the healthcare system and economy. Therefore, it is imperative to establish the link between the two, so as to prevent disease progression and complications. Methods: The study was an observational retrospective study done in Karachi, from November 2021 to May 2022. It was conducted on 255 patients who were diagnosed with NAFLD, and the presence of CKD was then determined by calculating their GFRs. Results: Out of the 255 patients diagnosed with hepatosteatosis, 76% had a normal GFR, 20% had a mild decrease and 4% were noted to have a moderate reduction in their GFR. When cross-tabulated with CAP score, it was found that 28% had S1 grade steatosis, out of which 85% had a normal GFR, 13% had a mild decrease and 2% had a moderate decrease in GFR. 22% had S2 grade steatosis, out of which 76% had a normal GFR, 18% had a mild decrease and 6% had a moderate reduction in GFR. 50% patients had S3 grade steatosis, out of which 70% had a normal GFR, 25% had a mild decrease and 5% had a moderate reduction in GFR. Conclusion: There is an association present between NAFLD and the development of low GFR. Therefore, it is important that patients diagnosed with NAFLD are regularly screened for CKD, so as to prevent its development and complications.

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Correlation Between Non-Alcoholic Fatty Liver and Chronic Kidney Disease

Cited by 2 publications

References 14 publications

Influence of Nonalcoholic Fatty Liver Disease on the Occurrence and Severity of Chronic Kidney Disease

Influence of Nonalcoholic Fatty Liver Disease on the Occurrence and Severity of Chronic Kidney Disease

Association of Low GFR and Non-Alcoholic Hepatosteatosis on Fibroscan of Liver

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