Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy

Moreau, Johanna; Ordan, Marie-Amélie; Barbe, Coralie; Mazza, Camille; Perrier, Marine; Botsen, Damien; Brasseur, Mathilde; Portefaix, Christophe; Renard, Yohann; Tallière, Barbara; Bertin, Éric; Hoeffel, Christine; Bouché, Olivier

doi:10.1002/cam4.2238

Cited by 33 publications

(30 citation statements)

References 49 publications

(106 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A correlation between ASMI and HGS has recently been described in sarcopenia due to cancer-cachexia [ 47 ]. In agreement with those results, we found a significant association between muscle atrophy and dynapenia in COPD participants.…”

Section: Discussionmentioning

confidence: 99%

Circulating Biomarkers of Accelerated Sarcopenia in Respiratory Diseases

Qaisar

Karim

Muhammad

et al. 2020

Biology

View full text Add to dashboard Cite

Skeletal muscle dysfunction is a critical finding in many respiratory diseases. However, a definitive biomarker to assess muscle decline in respiratory diseases is not known. We analyzed the association of plasma levels of glycoprotein Dickkopf-3 (Dkk-3), c-terminal agrin fragment-22 (CAF22) and microRNAs miR-21, miR-134a, miR-133 and miR-206 with hand-grip strength (HGS) and appendicular skeletal mass index (ASMI) in male, 54–73-year-old patients with chronic obstructive pulmonary diseases (COPD), asthma or pulmonary TB (n = 83–101/group). Patients with respiratory diseases showed a reduction in HGS and gait speed, while a reduction in ASMI was only found in patients with pulmonary TB. Among the sarcopenia indexes, HGS showed the strongest correlation with plasma CAF22, miR-21 and miR-206 levels while ASMI showed the strongest correlation with Dkk-3 and miR-133 in respiratory diseases. We found a modest-to-significant increase in the plasma markers of inflammation, oxidative stress and muscle damage, which had varying degrees of correlations with Dkk-3, CAF22 and selected micro RNAs (miRs) in respiratory diseases. Taken together, our data show that plasma levels of Dkk-3, CAF22 and selected miRs can be useful tools to assess accelerated sarcopenia phenotype in the elderly with respiratory diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Circulating Biomarkers of Accelerated Sarcopenia in Respiratory Diseases

Qaisar

Karim

Muhammad

et al. 2020

Biology

View full text Add to dashboard Cite

show abstract

“…In cancer patients, lower HGS values are associated with unfavorable clinical outcomes, such as longer hospital stays, poor quality of life, postoperative complications and mortality [33,36,50]. However, the measure is still seldom used in hospital and outpatient clinical practice, as there are no specific cutoff points for cancer patients and for the evaluation of reduced HGS values in non-elderly subjects [39,50].…”

Section: Discussionmentioning

confidence: 99%

Presence of dynapenia and association with anthropometric variables in cancer patients

et al. 2020

View full text Add to dashboard Cite

Background Dynapenia is defined as an age-related loss of muscle strength. There is little information on dynapenia in cancer patients and on how it relates to anthropometric variables. The aim of this study was to analyze the presence of dynapenia and its association with anthropometric variables in hospitalized cancer patients. Methods Participants comprised adult and elderly cancer patients evaluated within the first 48 h of hospital admission to a tertiary public hospital, a referral center for gastrointestinal tract surgery. Anthropometric variables were measured according to standardized protocols. Dynapenia was identified based on handgrip strength (HGS), according to the cutoff points defined by the European Working Group on Sarcopenia in Older People (EWGSOP2), with values for women < 16 kg and for men < 27 kg. Statistical analysis was performed using SPSS software, version 22.0, with a significance level of 5%. Results This study included 158 patients aged in average 59.5 ± 14.0 years; of these, 53.6% were elderly, 58.9% non-white and 59.5% had some degree of malnutrition. The most prevalent type of cancer was that of the lower gastrointestinal tract (33.5%). The presence of dynapenia was observed in 23.4% of the patients and cachexia in 36.1%. There was an association between dynapenia with age (p < 0.001), life stage (p = 0.002) and race/color (p = 0.027), and also with body mass index (BMI) (p = 0.001) and adductor pollicis muscle thickness (APMT) of both hands (p < 0.05). After logistic regression analysis, adjusted for the sociodemographic variables, the APMT of the dominant hand and the low weight determined by body mass index remained associated with the occurrence of dynapenia (p < 0.05). Conclusions In this study we confirmed that dynapenia was present in cancer patients, being associated with APMT of the dominant hand and low weight. HSG was proven to be a reliable and complementary measure to be added to the process of assessing nutritional status, contributing to the nutritional diagnosis of these patients and to the detection of early muscle depletion.

show abstract

“…Our study also showed a correlation between HGS and the SARC-CalF score. Moreau et al (28), when studying patients with GIT cancer, demonstrated a strong correlation between the measurement of HGS and muscle mass. Of the 150 patients evaluated by these researchers, 80 % showed loss of muscle mass and strength, with a consequent progression to sarcopenia.…”

Section: Resultsmentioning

confidence: 95%