Correlation between MS lesions and disability using 3D voxel-based statistical analysis

Charil, Arnaud; Zijdenbos, Alex P.; Boelman, Cyrus; Taylor, Jonathan; Worsley, Keith J.; Evans, Alan C.

doi:10.1016/s1053-8119(00)91601-x

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“…Patients affected by impaired cognitive functions caused by neurological conditions such as vascular dementia and Parkinson's disease also display issues in controlling bowel and bladder function [9,10]. The association between cognitive performances and bowel/bladder control may depend upon the strong overlap of brain structures activated by both functions, namely, the prefrontal cortex, the thalamus, the cerebellum and the brainstem [11,12]. As cognitive impairment can be detected in up to 75%…”

Section: Introductionmentioning

confidence: 99%

Interplay Between Cognitive and Bowel/Bladder Function in Multiple Sclerosis

et al. 2021

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Purpose: to evaluate the prevalence of bowel/bladder dysfunction in multiple sclerosis (MS) and the association with cognitive impairment. Methods:We prospectively enrolled 150 MS patients. Patients were administered the Symbol Digit Modality Test (SDMT), and filled the Neurogenic Bowel Dysfunction Score (NBDS) and the Actionable Bladder Symptom Screening Tool (ABSST). Association between bowel/bladder dysfunction and cognitive function was assessed through hierarchical regression models using SDMT and clinic-demographic features as independent variables and NBDS or ABSST score as dependent variables.Results: Prevalence for bowel/bladder deficit was 44.7%, with 26 patients (17.3%) suffering from bowel deficits and 60 patients (40%) from bladder deficits. Total NBDS and ABSST correlated with SDMT (coeff. = -0.10, p<0.001 and coeff. = -0.03, p=0.04, respectively) after correction for demographic features and physical disability.Conclusions: Bowel/bladder disorders are common in MS and are associated with both physical and cognitive disability burden. As SDMT is embedded into routine clinical assessment, a lower score may warrant investigating bowel/bladder dysfunction due their strong interplay.

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Section: Introductionmentioning

confidence: 99%