Correlation between menopausal symptoms and everyday cognition in Chinese (peri)menopausal women

Huang, Wenjun; Jiang, Shu‐Heng; Geng, Longlong; Li, Changbin; Tao, Minfang

doi:10.1080/09513590.2021.1892629

Cited by 9 publications

(5 citation statements)

References 24 publications

(32 reference statements)

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“…Menopausal symptoms were assessed using the menopausal rating scale (MRS) [ 32 , 33 ]. This questionnaire regroups 11 items, including hot flashes, heart discomfort, sleep disturbance, depressive mood, irritability, anxiety, physical/mental fatigue, sexual problems, bladder discomfort, vaginal dryness and muscle discomfort.…”

Section: Methodsmentioning

confidence: 99%

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A Cross-Sectional Comparison of Arterial Stiffness and Cognitive Performances in Physically Active Late Pre- and Early Post-Menopausal Females

et al. 2022

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Menopause accelerates increases in arterial stiffness and decreases cognitive performances. The objective of this study was to compare cognitive performances in physically active pre- and post-menopausal females and their relationship with arterial stiffness. We performed a cross-sectional comparison of blood pressure, carotid–femoral pulse wave velocity (cf-PWV) and cognitive performances between physically active late pre- and early post-menopausal females. Systolic (post-menopause—pre-menopause: +6 mmHg [95% CI −1; +13], p = 0.27; ŋ2 = 0.04) and diastolic (+6 mmHg [95% CI +2; +11], p = 0.06; ŋ2 = 0.12) blood pressures, and cf-PWV (+0.29 m/s [95% CI −1.03; 1.62], p = 0.48; ŋ2 = 0.02) did not differ between groups. Post-menopausal females performed as well as pre-menopausal females on tests evaluating executive functions, episodic memory and processing speed. Group differences were observed on the computerized working memory task. Post-menopausal females had lower accuracy (p = 0.02; ŋ2 = 0.25) but similar reaction time (p = 0.70; ŋ2 < 0.01). Moreover, this performance was inversely associated with the severity of menopausal symptoms (r = −0.38; p = 0.05). These results suggest that arterial stiffness and performance on tests assessing episodic memory and processing speed and executive functions assessing inhibition and switching abilities did not differ between physically active pre- and post-menopausal females. However, post-menopausal females had lower performance on a challenging condition of a working memory task, and this difference in working memory between groups cannot be explained by increased arterial stiffness.

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Section: Methodsmentioning

confidence: 99%

“…The total score was calculated as the sum of the scores on each item. The severity of menopausal symptoms is divided into 4 levels based on the MRS scores: 0–4 points = asymptomatic, 5–8 points = mild, 9–15 points = moderate and ≥16 points = severe [ 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

A Cross-Sectional Comparison of Arterial Stiffness and Cognitive Performances in Physically Active Late Pre- and Early Post-Menopausal Females

et al. 2022

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“…On the contrary to the present results, Rubin et al 13 recorded that anxiety was correlated with lower scores in verbal learning and memory tasks. Huang et al 23 also documented anxiety and mental fatigue as the significant predictors of everyday cognitive decline.…”

Section: Cognitive Performance and Menopausal Symptomsmentioning

confidence: 99%

“…19 Limited studies have been conducted to investigate the impact of menopausal symptoms on the cognitive performance and have presented conflicting results. As some of the researchers reported lack of association, 20 while others 13,14,[21][22][23] indicated a negative association between the occurrence of menopausal symptoms and cognitive abilities of the women. Given these ambiguities, it is imperative to explore whether the cognitive performance of women is sensitive to the severity of the menopausal symptoms, so that the cognitive health of the women experiencing menopausal transition can be improved.…”

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confidence: 99%

Is cognitive performance of women sensitive to the severity of menopausal symptoms?

Kaur

2022

Menopause

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Objective: Menopause is a natural phenomenon among women during their midlife, which is accompanied by unfavorable physical, physiological, and psychological consequences. Therefore, the major aim of the present crosssectional study was to examine whether the cognitive performance of women is sensitive to the severity of menopausal symptoms.Methods: A total number of 404 rural women aged between 40 and 65 years were included in the present study. The menopausal symptoms and cognitive performance of the women were assessed using the Greene Climacteric Scale and Hindi Mini-Mental State Examination scale respectively.Results: The results of the present study demonstrated that women experiencing severe menopausal symptoms (higher Total Greene climacteric score) presented significantly lower mean values for orientation (8.11 vs 8.90, P < 0.001), registration (2.77 vs 2.91, P < 0.001), attention (4.31 vs 4.48, P < 0.01), recall (2.26 vs 2.53, P < 0.05), and language/visuo-spatial skills (7.13 vs 7.91, P < 0.001) as compared with their counterparts with mild menopausal symptoms. The multivariate linear regression model (after adjustment for age, marital status, and educational status) recorded severe depression and greater sexual dysfunction as the factors significantly associated with lower Mini-Mental State Examination scores.Conclusion: Hence, the findings of the present study indicated that the cognitive performance of women was sensitive to severe depression and sexual dysfunction.

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“…Later-life decline in cognitive function can signal risk of incident dementia 14,15 and menopause is associated with cognitive changes 7,8,16,17 . Recent cross-sectional studies have found spontaneous menopause to be associated with poorer cognitive performance in the domains of language 18,19 , memory 8,[20][21][22][23] , visuo-spatial 24 , and executive function 20,[24][25][26][27][28] . However, studies have not determined the nature of this association -whether cognition is related to ovarian cessation, itself, or to an additive effect of multiple menopausal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Menopausal symptom burden as a predictor of mid- to late-life cognitive function and mild behavioral impairment symptoms: A CAN-PROTECT study

Crockford,

Guan,

Einstein

et al. 2024

Preprint

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Background Recent evidence suggests the experience of menopausal symptoms (i.e., perimenopausal symptoms) may be associated with cognitive and behavioural changes. We investigated these two relationships in a sample of post-menopausal females. Design Cross-sectional observational study. Setting Participant data was collected from the Canadian Platform for Research Online to Investigate Health, Quality of Life, Cognition, Behaviour, Function, and Caregiving in Aging (CAN-PROTECT) study. Participants 896 post-menopausal female participants. Methods Menopausal symptom burden was operationalized by summing the total number of recalled perimenopausal symptoms experienced. Cognitive function was measured using the Everyday Cognition (ECog-II) Scale, with higher scores reflecting greater severity. Mild Behavioral Impairment (MBI) was measured using the Mild Behavioral Impairment Checklist (MBI-C), with higher scores reflecting greater severity. A negative-binomial regression model examined the relationship between menopausal symptom burden and cognitive function, while a zero-inflated negative binomial regression model examined the relationship between menopausal symptom burden and MBI symptoms. Models adjusted for age, years of education, age of menopausal onset, type of menopause, and hormone therapy (HT). Age of menopausal onset and use of HT in the two associations were investigated with moderation analyses. Results Greater menopausal symptom burden was associated with higher ECog-II total scores (b [95% confidence interval (CI)] = 5.37 [2.85, 7.97]) and higher MBI-C total scores (b [95% CI] = 6.09 [2.50, 9.80]). Use of HT did not significantly associate with ECog-II total scores (b [95% CI] = -10.98 [-25.33, 6.35]), however, HT was significantly associated with lower MBI-C total scores (b [95% CI] = -26.90 [-43.35, -5.67]). Conclusions Menopausal symptom burden is associated with poorer cognitive function and more MBI symptoms in mid- to late life. HT may help mitigate symptoms of MBI. These findings suggest the experience of menopause may indicate susceptibility to cognitive and behavioural changes, both markers of dementia.

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Correlation between menopausal symptoms and everyday cognition in Chinese (peri)menopausal women

Cited by 9 publications

References 24 publications

A Cross-Sectional Comparison of Arterial Stiffness and Cognitive Performances in Physically Active Late Pre- and Early Post-Menopausal Females

A Cross-Sectional Comparison of Arterial Stiffness and Cognitive Performances in Physically Active Late Pre- and Early Post-Menopausal Females

Is cognitive performance of women sensitive to the severity of menopausal symptoms?

Menopausal symptom burden as a predictor of mid- to late-life cognitive function and mild behavioral impairment symptoms: A CAN-PROTECT study

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