Correlation between Melperone Plasma Concentrations and Changes in the Effective Refractory Period of the Right Atrium and Ventricle of the Dog

ABBREVIATIONS MDP = maximal diastolic potential, AP = action potential, Vmax = maximum rate of rise, ERP = effective refractory period, MAP = monophasic action potential, MAPD,, = time for 50% repolarization of MAP. ABSTRACTThe effect of antiarrhythmic drugs on myocardial refractoriness may be due to changes either in V, , , of phase 0 or the phase of repolarization of the AP or both. By using programmed electrical stimulation in combination with MAP recordings at different pacing rates in :he intact dog heart, it was possible to classify and to a certain extent to elucidate the mode of action of various cardioactive drugs in vivo.

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CLASSIFICATION OF CARDIOACTIVE DRUGS IN VIVO BY USING PROGRAMMED ELECTRICAL STIMULATION IN COMBINATION wITH MONOPHASIC ACTION POTENTIAL RECORDINGS AT DIFFERENT PACING RATES

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Amlie

Refsum

1981

Journal of Internal Medicine

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Correlation between Melperone Plasma Concentrations and Changes in the Effective Refractory Period of the Right Atrium and Ventricle of the Dog

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CLASSIFICATION OF CARDIOACTIVE DRUGS IN VIVO BY USING PROGRAMMED ELECTRICAL STIMULATION IN COMBINATION wITH MONOPHASIC ACTION POTENTIAL RECORDINGS AT DIFFERENT PACING RATES

CLASSIFICATION OF CARDIOACTIVE DRUGS IN VIVO BY USING PROGRAMMED ELECTRICAL STIMULATION IN COMBINATION wITH MONOPHASIC ACTION POTENTIAL RECORDINGS AT DIFFERENT PACING RATES

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