Correlation between mean platelet volume and B-type natriuretic peptide concentration in emergency patients with heart failure

Budak, Yasemin; Huysal, Kağan; Demirci, Hakan

doi:10.11613/bm.2015.012

Cited by 24 publications

(20 citation statements)

References 34 publications

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“…NLR has been recently studied as a potential biomarker to determine inflammation in cardiac and noncardiac disorders including coronary artery disease, gastrointestinal diseases, and malignancies [18][19][20]. NLR elevation has also been associated with poor prognosis in acute coronary syndromes and stable coronary heart diseases [21,22].…”

Section: Discussionmentioning

confidence: 99%

Novel hematologic inflammatory parameters to predict acute mesenteric ischemia

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Akkoç

Savas

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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Acute mesenteric ischaemia (AMI) is an emergency condition that requires urgent diagnosis. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) have been studied as inflammatory biomarkers in atherosclerosis, but data regarding AMI are lacking. The study population included patients with AMI (n = 46) versus age and sex-matched healthy controls (n = 46). Computed multidetector tomographic angiography was performed to diagnose AMI. NLR and PLR were calculated using complete blood count. C-reactive protein (CRP) levels were also analyzed. Neutrophil levels and lymphocytes were significantly higher in patients with AMI than in the control individuals (P < 0.001 and P = 0.43, respectively). NLR levels were significantly higher in patients with AMI compared with that in the control individuals (P < 0.001). Platelet levels did not reach statistical significance between the groups (P = 0.709). However, patients with AMI had significantly higher PLR levels than the control group (P = 0.039). CRP levels on admission were higher in patients with AMI in comparison with control individuals. There was also a positive correlation between NLR and CRP (r = 0.548, P < 0.001), and between PLR and CRP (r = 0.528, P < 0.001). NLR level greater than 4.5, measured on admission, yielded an area under the curve value of 0.790 (95% confidence interval 0.681-0.799, sensitivity 77%, specificity 72%), and PLR level of greater than 157 yielded an area under the curve value of 0.604 (95% confidence interval 0.486-0.722, sensitivity 59%, specificity 65%). Patients with AMI had increased NLR, PLR, and CRP levels compared with controls. Increased NLR and PLR was an independent predictor of AMI.

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Section: Discussionmentioning

confidence: 99%

Novel hematologic inflammatory parameters to predict acute mesenteric ischemia

Toptaş

Akkoç

Savas

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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“…Numerous papers have documented prognostic value of mean platelet volume (MPV) in cardiovascular pathology [1][2][3][4][5][6][7], including published research on correlation between MPV and periodontal disease (PDe) in coronary patients [8]. A thorough search on correlation between MPV and exacerbated heart failure revealed only 2 publications in this area [9,10]. MPV has not yet been studied in patients with congestive heart failure (CHF), including those with coexistent PDe.…”

Section: Introductionmentioning

confidence: 99%

Simple platelet markers: Mean platelet volume and congestive heart failure coexistent with periodontal disease. Pilot studies

et al. 2019

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“…Some of these parameters have been accepted as additional markers in diagnosing various clinical conditions [1][2][3][4][5]. They are cost effective and easier to perform in a routine setting than tests for some other markers.…”

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confidence: 99%

Relationship between CRP, systemic immune-inflammation index and routine hemogram related inflammatory markers in low grade inflammation

Üstündağ¹

2018

Int J Med Biochem

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Research ArticleR ecent advances in technology led to the quantitation of new parameters with automated hematology analyzers. Some of these parameters have been accepted as additional markers in diagnosing various clinical conditions [1][2][3][4][5]. They are cost effective and easier to perform in a routine setting than tests for some other markers. C-reactive protein (CRP) is a commonly used inflammation marker in both acute and chronic inflammation. Most healthy individuals have a CRP concentration of 3 mg/L or less; a CRP level higher than 10 mg/L indicates a clinically significant inflammatory disease [6]. Low-grade inflammation typically refers to conditions in which Objectives: The term low-grade inflammation is usually used to indicate chronic conditions in which the findings of classic, clinical inflammation are lacking, but there is an elevated C-reactive protein (CRP) level of 3 to 10 mg/L. Recently, the systemic immune-inflammation index (SII) was developed based on lymphocyte, neutrophil, and platelet counts, which can project the inflammatory and immune imbalances. The aim of this study was to examine the SII and new parameters derived from hemograms to determine if they have the potential to detect patients with subclinical lowgrade inflammation in an unselected, elderly, outpatient population. Methods: The CRP level was analyzed with a BN II System nepholometer (Siemens Healthineers, Erlangen, Germany). Participants were stratified according to CRP level: Group 1 had a serum CRP result <3.0 mg/L and Group 2 had a serum CRP result 3.0-9.0 mg/L. Blood samples that had been analyzed with an automated hematology analyzer (Mindray BC-5800; Mindray Biomedical Electronics Co., Ltd., Shenzhen, China) were selected for evaluation of the results. The SII (neutrophil x platelet / lymphocyte), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were calculated. PLR (r=0.773; p<0.001), and the platelet count (r=0.653; p<0.001) was found. However, there was no correlation between the CRP, SII (r=-0.312; p=0.210), and PLR (r=-0.165; p=0.117). Conclusion: A high PLR and SII appears to be associated with subclinical low-grade inflammation. These data do not support hematological screening parameters as a substitute for CRP. These findings are limited to the cohort studied here, and may not be entirely applicable to other ethnic origins. Keywords: C-reactive protein, lymphocyte, neutrophil, platelet Relationship between C-reactive protein, systemic immuneinflammation index, and routine hemogram-related inflammatory markers in low-grade inflammation

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Correlation between mean platelet volume and B-type natriuretic peptide concentration in emergency patients with heart failure

Cited by 24 publications

References 34 publications

Novel hematologic inflammatory parameters to predict acute mesenteric ischemia

Novel hematologic inflammatory parameters to predict acute mesenteric ischemia

Simple platelet markers: Mean platelet volume and congestive heart failure coexistent with periodontal disease. Pilot studies

Relationship between CRP, systemic immune-inflammation index and routine hemogram related inflammatory markers in low grade inflammation

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