Correlation Between Maximal Tongue Pressure and Swallowing Function in Spinal and Bulbar Muscular Atrophy

Gwak, Dae-Won; Jung, Sung Il; Min, Yu-Sun; Park, Jin-Sung; Cho, Hee Jin; Park, Donghwi; Hong, Min Woo; Kang, Min‐Gu

doi:10.3389/fneur.2021.704788

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Notably, painful abdominal cramps seemed to be specific to HMSN-P. Painful abdominal cramps have not described in related diseases, e.g., ALS, spinal bulbar muscular atrophy (SBMA), or Charcot-Marie-Tooth (CMT) disease (10)(11)(12)(13). Fasciculation in the face during tongue thrust has been observed in ALS and SBMA patients but not HMSN-P, and CMT disease shows findings of lower-extremity predominance.…”

Section: Resultsmentioning

confidence: 94%

Re-survey of 16 Japanese patients with advanced-stage hereditary motor sensory neuropathy with proximal dominant involvement (HMSN-P): Painful muscle cramps for early diagnosis

Shoji,

Sakamoto,

Saito

et al. 2023

IRDR

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painful muscle cramp, abdominal cramp, hereditary motor sensory neuropathy with proximal dominant involvement, HMSN-P, nucleic acid medicine, induced pluripotent stem cell Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is an intractable neurological disease with autosomal dominant inheritance, four-limb weakness, sensory impairment, and a slowly progressive course. HMSN-P patients develop four-limb paralysis at the advanced-stage, as in amyotrophic lateral sclerosis (ALS). There is a natural 20-to 30-year course from initial painful muscle cramps and four-limb paralysis to respiratory dysfunction. A delay in the diagnosis of HMSN-P occurs due to the 20-to 30-year span from the initial symptom(s) to typical quadriplegia. Its early diagnosis is important, but the involvement of painful muscle cramps as an early symptom has not been clear. Following our earlier survey, we conducted a re-survey focusing on painful muscle cramps, assistive-device use, and hope for specific therapies in 16 Japanese patients with advanced-stage HMSN-P. Fifteen patients presented painful muscle cramps as the initial symptom, and muscle cramps in the lower abdomen including the flank were described by 10 of the patients. The presence of painful muscle cramps including those in the abdominal region may be a clue for the early diagnosis of HMSN-P. Painful abdominal cramps have not described in related diseases, e.g., ALS, spinal muscular atrophy, and Charcot-Marie-Tooth disease. Recent patient-welfare improvements and advances in assistive devices including robot-suit assistive limbs are delaying the terminal state of HMSN-P. Regarding specific therapies for HMSN-P, many patients choose both nucleic acid medicine and the application of induced pluripotent stem cells as a specific therapy for HMSN-P.

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Section: Resultsmentioning

confidence: 94%

Re-survey of 16 Japanese patients with advanced-stage hereditary motor sensory neuropathy with proximal dominant involvement (HMSN-P): Painful muscle cramps for early diagnosis

Shoji,

Sakamoto,

Saito

et al. 2023

IRDR

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“…Measurements during functional activities such as swallowing are also demanding because the procedure of swallowing itself is very complex, consists of different steps [33], and depends on parameters such as the type of device used [35], the type of bolus [36], the amount of occlusal units [35], etc. Maximum tongue pressure is a simpler measurement to take, is less dependent on other external factors, can be compared between studies and/or patients, is correlated with the swallowing function [35], and has been used as a diagnostic feature to detect muscular diseases [37,38].…”

Section: Discussionmentioning

confidence: 99%

Relation between Maximum Oral Muscle Pressure and Dentoalveolar Characteristics in Patients with Cleft Lip and/or Palate: A Prospective Comparative Study

Van Geneugden,

Verdonck,

Willems

et al. 2023

JCM

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Background: Perioral muscle function, which influences maxillofacial growth and tooth position, can be affected in patients with oral clefts due to their inherent anatomical characteristics and the multiple surgical corrections performed. This research aims to (1) compare the maximum oral muscle pressure of subjects with and without isolated cleft palate (CP) or unilateral cleft lip and palate (UCLP), (2) investigate its influence on their dentoalveolar characteristics, and (3) investigate the influence of functional habits on the maximum oral muscle pressure in patients with and without cleft. Material and methods: Subjects with and without CP and UCLP seeking treatment at the Department of Orthodontics of University Hospitals Leuven between January 2021 and August 2022 were invited to participate. The Iowa Oral Performance Instrument (IOPI) was used to measure their maximum tongue, lip, and cheek pressure. An imbalance score was calculated to express the relationship between tongue and lip pressure. Upper and lower intercanine (ICD) and intermolar distance (IMD) were measured on 3D digital dental casts, and the presence of functional habits was reported by the patients. The data were analyzed with multivariable linear models, correcting for age and gender. Results: 44 subjects with CP or UCLP (mean age: 12.00 years) and 104 non-affected patients (mean age: 11.13 years) were included. No significant differences in maximum oral muscle pressure or imbalance score were detected between controls and clefts or between cleft types. Significantly smaller upper ICDs and larger upper and lower IMDs were found in patients with clefts. A significant difference between controls and clefts was found in the relationship between oral muscle pressure and transversal jaw width. In cleft patients, the higher the maximum tongue pressure, the wider the upper and lower IMD, the higher the lip pressure, the smaller the upper and lower ICD and IMD, and the higher the imbalance score, the larger the upper and lower IMD and lower ICD. An imbalance favoring the tongue was found in cleft patients. The influence of functional habits on the maximum oral muscle pressure was not statistically different between clefts and controls. Conclusion: Patients with CP or UCLP did not present reduced maximum oral muscle pressure compared with patients without a cleft. In cleft patients, tongue pressure was consistently greater than lip pressure, and those who presented a larger maxillary width presented systematically higher imbalance scores (favoring the tongue) than those with narrow maxillae. Therefore, the influence of slow maxillary expansion on maximum oral muscle pressure in cleft patients should not be underestimated.

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“…Impairment of the tongue seems to represent a major risk factor for aspiration [18]. One study showed a correlation between tongue pressure and the severity of dysphagia and physical performance in 39 patients with ALS [19]. Although swallowing pressures are known to be considerably weaker than maximum pressure exerted by tongue-palate contact pressure tasks, specific measures of maximum tongue strength have been shown to be associated with overall swallowing performance [20].…”

Section: Physiopathology Of Dysphagia: Focusing On Alsmentioning

confidence: 99%

Dysphagia of Neurological Origin – Amyotrophic Lateral Sclerosis

Argente-Pla¹,

García‐Malpartida²,

Micó-García³

et al. 2022

Dysphagia - New Advances

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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of unknown etiology that affects upper and lower motor neurons resulting in progressive atrophy of skeletal muscles. There are two forms of ALS: spinal motor neuron injury and bulbar paresis. Dysphagia is a highly prevalent severe and invalidating symptom in ALS: almost 80% of ALS patients with bulbar paresis will develop dysphagia. Also, dysphagia is one of the most common and serious complications, with respiratory insufficiency, in patients with ALS as it exposes them to malnutrition, dehydration and aspiration pneumonia. These conditions are reported to be associated with a minor survival in patients with ALS. Screening for dysphagia must be performed in all ALS patients at diagnosis and during the follow-up to approach dysphagia as soon as possible. This chapter includes the latest developments in the assessment and approach of dysphagia in ALS patients.

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Correlation Between Maximal Tongue Pressure and Swallowing Function in Spinal and Bulbar Muscular Atrophy

Cited by 4 publications

References 31 publications

Re-survey of 16 Japanese patients with advanced-stage hereditary motor sensory neuropathy with proximal dominant involvement (HMSN-P): Painful muscle cramps for early diagnosis

Re-survey of 16 Japanese patients with advanced-stage hereditary motor sensory neuropathy with proximal dominant involvement (HMSN-P): Painful muscle cramps for early diagnosis

Relation between Maximum Oral Muscle Pressure and Dentoalveolar Characteristics in Patients with Cleft Lip and/or Palate: A Prospective Comparative Study

Dysphagia of Neurological Origin – Amyotrophic Lateral Sclerosis

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