Correlation between maternal and neonatal blood vitamin D levels and its effect on the newborn anthropometry

Sathish, Paulraj; Raveendran, Sajeethakumari; Padma, Ramasamy; Balakrishnan, Doraisami; Muthusami, Muthulakshmi

doi:10.18203/2320-1770.ijrcog20162821

Cited by 16 publications

(15 citation statements)

References 19 publications

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“…20,21 This is in contrast to a study done by Paulraj Sathish et al, which showed a statistically significant correlation between cord vitamin D levels and anthropometry. 22 Limitation of this study was group comprised of mainly urban mothers and the sample size was small due to financial constraints.…”

Section: Discussionmentioning

confidence: 99%

A study on vitamin D levels in preterm and term neonates and their mothers

Thomas

Khan

Paul

et al. 2020

Int J Contemp Pediatr

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Background: Vitamin D is a fat-soluble vitamin which has immunomodulatory and anti-inflammatory effects. Vitamin D deficiency is a worldwide problem and yet is one of the most under diagnosed and under treated nutritional deficiency. Despite India being in the tropical zone with plentiful sunlight, there is a wide prevalence of vitamin D deficiency.Methods: Cross sectional descriptive study done in a tertiary care hospital involving 30 mother baby dyads equally divided into term and preterm babies. Maternal vitamin D levels (before delivery) and cord blood vitamin D levels (after delivery) were estimated.Results: All the mothers had low vitamin D levels, 93% having deficiency and 7% having insufficiency. The maternal vitamin D levels correlated with cord blood vitamin D levels. There was significant correlation between maternal vitamin D levels and cord blood vitamin D levels with maternal age and parity. There was no correlation between maternal vitamin D levels with gestational age, sociodemographic profile or neonatal anthropometry.Conclusions: Vitamin D deficiency is widely prevalent even in well-nourished mothers. Vitamin D supplementation may be helpful in antenatal mothers. Larger studies are needed to study the prevalence of vitamin D deficiency in mothers and babies and look for effectiveness of supplementation.

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Section: Discussionmentioning

confidence: 99%

A study on vitamin D levels in preterm and term neonates and their mothers

Thomas

Khan

Paul

et al. 2020

Int J Contemp Pediatr

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“…The literature reports unanimously agree that cord blood serum concentration of vitamin D is directly correlated with maternal levels. Regardless, cord levels may be higher ( 24 , 27 – 29 ), equal to ( 12 , 14 , 19 ), and lower than maternal venous vitamin D concentration ( 30 , 31 ). Neonates born to mothers with adequate vitamin D concentrations during pregnancy are supplied until 8 weeks of life ( 2 , 32 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, some experts are of the opinion that maternal levels of at least >20 ng/ml will ensure adequate vitamin D concentration in the neonate ( 11 ), while latest publications suggest that 25(OH)D concentration should be at least 40 ng/ml ( 2 ). With 30 ng/ml as the threshold value for adequate concentration, vitamin D insufficiency or deficiency is a common occurrence, affecting as many as 99–100% of pregnant women in Turkey ( 12 , 13 ), 85% in India ( 14 ), 69–95% in Central Europe ( 15 – 17 ), 52–85% in Southern Europe ( 18 , 19 ), 74% in the United States ( 20 ), and 63% in China ( 21 ). The contemporary lower reference range for cord blood vitamin D level is 20 ng/ml ( 1 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth

et al. 2018

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IntroductionVitamin D deficiency in pregnant women may result in reduced neonatal development due to the fact that systemic vitamin D status during fetal life depends on maternal concentrations. Some authors reported significant differences in neonatal anthropometric measurements depending on maternal vitamin D concentrations.ObjectiveThe aim of this study is to evaluate the relationship between maternal and cord blood concentrations of vitamin D and neonatal anthropometric measurements at birth.Materials and methodsThis study included 94 pregnant women, at term, who delivered at the Department of Obstetrics, Women’s Diseases and Gynecological Oncology, Medical University of Warsaw. Total serum 25(OH)D concentration was measured in mother–child pairs, and newborn anthropometric data were collected. A multiple regression analysis was used for statistical analysis.ResultsNo relationship between maternal and neonatal cord blood vitamin D concentrations vs. neonatal weight, length, head, and chest circumference at birth was found (p > 0.05). Severe vitamin D deficiency (<10 ng/ml) was detected in 10.6%, deficiency (10–20 ng/ml) in 39.4%, insufficiency (20–30 ng/ml) in 39.4%, and optimal vitamin D concentration (>30 ng/ml) only in 10.6% of the pregnant women. Cord blood vitamin D deficiency (<20 ng/ml) was found in 28.7% of the neonates.ConclusionNo differences between neonatal anthropometric measurements of infants born to mothers with normal and deficient vitamin D concentrations were found.

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“…This could happen because the mother had to fulfill her own vitamin D requirement beside her fetal. 19 Previous studies conducted to determine the correlation of vitamin D levels during early 4 , mid 20 , and late pregnancy, and/or cord blood at birth 8 with child development had been carried out in several countries with various results. 9 The previous part of this cohort study in Indonesia about associations between maternal vitamin D levels in early pregnancy (10-14 weeks gestation) with child development in the first year ages of life (3 months, 6 months, and 12 months), showed that ASQ scores in gross motor domains were significantly lower at 3 months of age, and did not have a significant difference for all developmental aspects at older ages (6 and 12 months).…”

Section: Discussionmentioning

confidence: 99%

“…9 The previous part of this cohort study in Indonesia about associations between maternal vitamin D levels in early pregnancy (10-14 weeks gestation) with child development in the first year ages of life (3 months, 6 months, and 12 months), showed that ASQ scores in gross motor domains were significantly lower at 3 months of age, and did not have a significant difference for all developmental aspects at older ages (6 and 12 months). 7,19 In this study, we examined cord blood vitamin D samples because maternal vitamin D could pass through the placenta and enter the fetal bloodstream, with the half-life around 2 months. Therefore, it could represent vitamin D level in the newborns.…”

Section: Discussionmentioning

confidence: 99%

Cord blood vitamin D is correlated with problem solving domain in early childhood neurodevelopment: A Cohort Study on Vitamin D Status and Its Impact during Pregnancy and Childhood in Indonesia

Supriadi¹,

Gumilang²,

Setiabudi³

et al. 2020

Preprint

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Fetal vitamin D level is known to influence brain development and subsequent postnatal neurodevelopment, although several studies stated that this correlation remains controversial. We aimed to determine the correlation between cord blood vitamin D level and neurodevelopmental status in the first 1000 days of life. This was a cohort study, located in Sukabumi and Waled districts of West Java, Indonesia, from 2016–2019. Subjects were term infants with no congenital abnormalities, born from pregnant women involved in a previously conducted cohort study. The cord blood sample collected at delivery was used to measure 25 (OH)-vitamin D level. Neurodevelopmental status was examined after the infants reached 6, 12, and 24 months of age using Ages and Stages Questionnaire-3 (ASQ-3). Statistical analysis was performed using rank Spearman’s correlation. Blood samples were collected from 116 subjects. The mean value of vitamin D levels was 16.2 ng/mL (8.0–35.4 ng/mL). As many as 12.9%, 65.5% and 21.6% of newborns had vitamin D deficiency, insufficiency and normal vitamin D levels. The correlation was found between cordblood vitamin D levels and the problem-solving domain at the age of 12 and 24 months old; r = 0.217, and r = 0.414 respectively. Multiple linier regression analysis result showed a decrease problem solving domain score of 0.641 was associated with decreased of vitamin D. Cordblood vitamin D level correlates with infant neurodevelopmental status. Screening of vitamin D level is crucial during pregnancy and early childhood to improve neurodevelopmental outcome.

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Correlation between maternal and neonatal blood vitamin D levels and its effect on the newborn anthropometry

Cited by 16 publications

References 19 publications

A study on vitamin D levels in preterm and term neonates and their mothers

A study on vitamin D levels in preterm and term neonates and their mothers

Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth

Cord blood vitamin D is correlated with problem solving domain in early childhood neurodevelopment: A Cohort Study on Vitamin D Status and Its Impact during Pregnancy and Childhood in Indonesia

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