Correlation between mast cells and survival rates in patients with pulmonary adenocarcinoma

Tomita, Masaki; Matsuzaki, Yasunori; Onitsuka, Toshio

doi:10.1016/s0169-5002(99)00076-8

Cited by 49 publications

(51 citation statements)

References 14 publications

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“…functions, including serving as natural cytotoxic effectors 32,33 and antitumor compounds, 34 and to be a favorable prognostic factor in surgically resected NSCLC, breast cancer, and colorectal cancer. [35][36][37] Although mast cells produce histamine, basic fibroblast growth factor, heparin, chymase, and tryptase, which have been shown to promote cancer progression, including in surgically resected NSCLC, gastric cancer, and endometrial cancer, 18,38 no significant relation to survival was found in this study.…”

Section: Discussionmentioning

confidence: 72%

Predominant infiltration of macrophages and CD8⁺ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer

Kawai

Ishii

Kubota

et al. 2008

Cancer

339

233

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BACKGROUND.The purpose of this study was to investigate whether tumor‐infiltrating immune cells in biopsy specimens can be used to predict the clinical outcome of stage IV nonsmall cell lung cancer (NSCLC) patients.METHOD.The authors performed an immunohistochemical study to identify and count the number of CD68+ macrophages, c‐kit+ mast cells, and CD8+ T cells in both cancer nests and cancer stroma in pretreatment biopsy specimens obtained from 199 patients with stage IV NSCLC treated by chemotherapy, and then analyzed for correlations between the number of immune cells and clinical outcome, including chemotherapy response and prognosis.RESULTS.There was no correlation between the number of immune cells in either cancer nests or stroma and chemotherapy response. Patients with more tumor‐infiltrating macrophages in cancer nests than in cancer stroma (macrophages, nests > stroma) had significantly better survival than nests < stroma cases median survival time (MST 440 days vs 199 days; P < .0001). Patients with more tumor‐infiltrating CD8+ T cells in cancer nests than in cancer stroma (CD8+ T cells: nests > stroma) showed significantly better survival than in nests < stroma cases (MST 388 days vs 256 days; P = .0070). The proportion of tumor‐infiltrating macrophages or CD8+ T cells between cancer nests and stroma became independent prognostic factors in the multivariate analysis. Neither the number of mast cells in nests nor in stroma correlated with the clinical outcome.CONCLUSIONS.Evaluation of the numbers of macrophages and CD8+ T cells in cancer nests and stroma are useful biomarkers for predicting the prognosis of stage IV NSCLC patients treated with chemotherapy, but could fail to predict chemotherapy response. Cancer 2008. © 2008 American Cancer Society.

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Section: Discussionmentioning

confidence: 72%

Predominant infiltration of macrophages and CD8⁺ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer

Kawai

Ishii

Kubota

et al. 2008

Cancer

339

233

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“…25 A high mast cell count is also a favorable prognostic factor in lung tumors. 26 It is not known why mast cells are beneficial in colorectal and lung cancer. There is great heterogeneity among mast cells; depending on their localization and environmental stimulation, they produce a variety of pharmacologically active substances.…”

Section: Discussionmentioning

confidence: 99%

Lymphatic Vessels in Colorectal Cancer and Their Relation With Inflammatory Infiltrate

Sacchi¹,

Weber²,

Aglianò³

et al. 2003

Diseases of the Colon &Amp; Rectum

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“…Studies correlating the presence of mast cells in prostate cancer (76)(77)(78), colorectal cancer (79)(80)(81)(82)(83)(84) and non-small cell lung cancer (32,(85)(86)(87)(88) have led to more nuanced interpretations. In prostate cancer, Nonomura and colleagues reported that the number of tryptase þ mast cells (that in this study were only observed around but not within the cancer foci) positively correlated with a high Gleason score and an advanced clinical stage of the prostate tumor, indicating that high numbers of such mast cells represent a poor prognostic factor for survival following treatment (76).…”

Section: Studies Linking Mast Cells To Tumors In Humansmentioning

confidence: 99%

Mast Cells: Potential Positive and Negative Roles in Tumor Biology

Marichal

Tsai

Galli

2013

Cancer Immunology Research

147

148

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Mast cells are immune cells that reside in virtually all vascularized tissues. Upon activation by diverse mechanisms, mast cells can secrete a broad array of biologically active products that either are stored in the cytoplasmic granules of the cells (e.g., histamine, heparin, various proteases) or are produced de novo upon cell stimulation (e.g., prostaglandins, leukotrienes, cytokines, chemokines, and growth factors). Mast cells are best known for their effector functions during anaphylaxis and acute IgE-associated allergic reactions, but they also have been implicated in a wide variety of processes that maintain health or contribute to disease. There has been particular interest in the possible roles of mast cells in tumor biology. In vitro studies have shown that mast cells have the potential to influence many aspects of tumor biology, including tumor development, tumor-induced angiogenesis, and tissue remodeling, and the shaping of adaptive immune responses to tumors. Yet, the actual contributions of mast cells to tumor biology in vivo remain controversial. Here, we review some basic features of mast cell biology with a special emphasis on those relevant to their potential roles in tumors. We discuss how using in vivo tumor models in combination with models in which mast cell function can be modulated has implicated mast cells in the regulation of host responses to tumors. Finally, we summarize data from studies of human tumors that suggest either beneficial or detrimental roles for mast cells in tumors. Cancer Immunol Res; 1(5); 269-79. Ó2013 AACR. Disclosure of Potential Conflicts of InterestNo potential conflicts of interest were disclosed.

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Correlation between mast cells and survival rates in patients with pulmonary adenocarcinoma

Cited by 49 publications

References 14 publications

Predominant infiltration of macrophages and CD8⁺ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer

Predominant infiltration of macrophages and CD8⁺ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer

Lymphatic Vessels in Colorectal Cancer and Their Relation With Inflammatory Infiltrate

Mast Cells: Potential Positive and Negative Roles in Tumor Biology

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Correlation between mast cells and survival rates in patients with pulmonary adenocarcinoma

Cited by 49 publications

References 14 publications

Predominant infiltration of macrophages and CD8+ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer

Predominant infiltration of macrophages and CD8+ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer

Lymphatic Vessels in Colorectal Cancer and Their Relation With Inflammatory Infiltrate

Mast Cells: Potential Positive and Negative Roles in Tumor Biology

Contact Info

Product

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Predominant infiltration of macrophages and CD8⁺ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer

Predominant infiltration of macrophages and CD8⁺ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer