Correlation between magnetic resonance imaging and ultrasound measurements of eye muscle thickness in thyroid-associated orbitopathy

Karhanová, Marta; Kovář, Radim; Fryšák, Zdeněk; Šín, Martin; Zapletalová, Jana; Řehák, J; Moreno, Herman

doi:10.5507/bp.2014.001

Cited by 13 publications

(5 citation statements)

References 37 publications

(53 reference statements)

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“…8–10 Routine and contrast magnetic resonance imaging are used to differentiate active from inactive Graves' orbitopathy based upon signal intensity value on short Tau inversion recovery images (STIR) and degree of contrast enhancement of the extra-ocular muscles, but there is overlap in signal intensity value and degree of enhancement. 11–14 Color Duplex ultrasound can differentiate congestive from fibrotic Graves' orbitopathy based upon the flow of the superior ophthalmic vein, but there is overlap in the resistive index of the superior ophthalmic vein and the ultrasound is an operator-dependent technique. 15,16 Computed tomography and isotope study may help in this differentiation, but they are associated with radiation exposure and overlap in cross-sectional areas of extra-ocular muscles at computed tomography and degree of isotope uptake at isotope study.…”

Section: Introductionmentioning

confidence: 99%

Performance of apparent diffusion coefficient of medial and lateral rectus muscles in Graves' orbitopathy

et al. 2017

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Objective The purpose of this study was to determine the performance of the apparent diffusion coefficient in the detection of involvement of the medial and lateral rectus muscles in patients with Graves' orbitopathy. Methods and materials This prospective study was conducted on 33 consecutive patients (16 males, 17 females with a mean age of 36 years) with Graves' orbitopathy and 18 age- and sex-matched volunteers. The patients and volunteers underwent diffusion-weighted magnetic resonance imaging of the orbit in the axial plane using echo-planar imaging. The apparent diffusion coefficient of the medial and lateral rectus muscles was calculated. Results The medial rectus muscle was more affected than the lateral rectus muscle. The mean apparent diffusion coefficient value of the medial and lateral rectus muscles was 1.81 ± 0.19 and 1.72 ± 0.07 × 10mm/s in patients with Graves' orbitopathy and 1.59 ± 0.06 and 1.51 ± 0.06 × 10 mm/s in volunteers, respectively. There was a significant difference in apparent diffusion coefficient values of the medial and lateral rectus muscles between patients with Graves' orbitopathy and volunteers ( p = 0.001). The classification performance as measured with area under the receiver operator characteristic curve was 0.89 (95% confidence interval: 0.732-0.904). The best performing threshold of the apparent diffusion coefficient value of the medial rectus muscle was 1.69 × 10 mm/s and associated efficiency was 86%, sensitivity was 97%, and specificity was 97%. Conclusion We concluded that the apparent diffusion coefficient of the medial rectus muscle can be used for diagnosis of Graves' orbitopathy.

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Section: Introductionmentioning

confidence: 99%

Performance of apparent diffusion coefficient of medial and lateral rectus muscles in Graves' orbitopathy

et al. 2017

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“…Na našem pracovišti vždy vyšetřujeme vnitřní a zevní přímý okohybný sval a v případě podezření na postižení dolního přímého svalu se snažíme Další nevýhodou UZ vyšetření šíře okohybných svalů je relativně velká interindividuální variabilita a zatížení subjektivní chybou. Na toto upozorňují i četné studie zaměřující se na korelaci jednotlivých zobrazovacích metod pro měření okohybných svalů, jejichž výsledky nejsou konzistentní [6][7][8][9]. Možných vysvětlení je hned několik.…”

Section: Ultrazvukové Nálezy U Endokrinní Orbitopatieunclassified

Ultrasound Examination of the Orbit in Patients With Thyroid- Associated Orbitopathy – Examination Guide and Recommendations for Everyday Practice. A Review

Karhanová,

Čivrný,

Kalitová

et al. 2024

CSO

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The purpose of this study is to present the possibilities and benefits of ultrasonography (US) of the orbit in the diagnosis and treatment of thyroid-associated orbitopathy (TAO). Methods: US examination of the orbit is an essential addition to clinical and laboratory examination in TAO patients. Nevertheless, it is often neglected in clinical practice or indicated with delay. Based on previously published studies and our experience with the diagnosis and treatment of TAO patients, we aim to highlight the clear benefit of US examination of the orbit and oculomotor muscles, not only for correct TAO diagnosis but also in the monitoring of the disease over time. However, knowledge of the drawbacks and limitations of this method is also essential, as we shall point out. It is always necessary to remember that US examination must be evaluated in connection with the clinical findings. A detailed recommendation for US examination of the extraocular muscles and the orbit based on our experiences with diagnosing and treating TAO patients in daily practice is also included. Conclusion: According to our experience, US examination of the orbit is an excellent and irreplaceable tool for timely TAO diagnosis and further disease monitoring. However, considerable examiner experience and detailed knowledge of the clinical and ultrasound manifestations of TAO are essential.

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“…However, due to its intrinsic principles, the accuracy and repeatability of ultrasound examination is susceptible to multiple factors in TED (i.e., measurement angle, artifacts, tissue fibrosis or calcification, postoperative morphological changes, etc.) ( 99 ). Therefore, the application of ultrasound imaging biomarkers is still limited to TED examination, diagnosis and morphological monitoring, while prediction models for treatment response based on ultrasound technique are few ( 100 ).…”

Section: Imaging Biomarkersmentioning

confidence: 99%

Predictive markers for anti-inflammatory treatment response in thyroid eye disease

Zhang,

Fan,

et al. 2023

Front. Endocrinol.

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Anti-inflammatory treatment is the primary and vital therapeutic approach for active, moderate-to-severe thyroid eye disease (TED). Accurate pretreatment prediction of treatment response is of paramount importance for the prognosis of patients. However, relying solely on the clinical activity score asa determinant of activity has led to unsatisfactory treatment outcomes. In recent years, significant advancements have been made in identifying predictive markers for anti-inflammatory treatment response in TED, clinical markers, body fluid biomarkers and imaging biomarkers. Several clinical studies have developed prediction models based on these markers. However, there is still a lack of comprehensive elucidation or comparison between the different markers. Therefore, this review aims to provide a detailed analysis of the definition, characteristics, and application of predictive markers for anti-inflammatory treatment response in TED. Through detailed literature search, 26 articles applying anti-inflammatory treatment effect prediction with a total of 1948 TED patients were used for analysis and discussion. By gaining a better understanding of the current research on predictive markers, we can accelerate and guide the exploration of treatment prediction strategies, leading us towards an era of precise therapy for TED.

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Correlation between magnetic resonance imaging and ultrasound measurements of eye muscle thickness in thyroid-associated orbitopathy

Cited by 13 publications

References 37 publications

Performance of apparent diffusion coefficient of medial and lateral rectus muscles in Graves' orbitopathy

Performance of apparent diffusion coefficient of medial and lateral rectus muscles in Graves' orbitopathy

Ultrasound Examination of the Orbit in Patients With Thyroid- Associated Orbitopathy – Examination Guide and Recommendations for Everyday Practice. A Review

Predictive markers for anti-inflammatory treatment response in thyroid eye disease

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