“…3 Some investigators now consider these lesions to be a particular form of superficial-type tumour 1,2,4 or a specific type of sessile adenoma. 3,5 Although large, nonpolypoid, colonic neoplasms are thought to exist, their precise biological characteristics remain unknown. We previously investigated the extent of apoptotic cell loss in large, H Yamada, H Hasegawa, H Iino et al Large, non-polypoid colorectal adenomas non-polypoid adenomas and found dominant apoptosis in lower parts of the tumour, which is thought to be a characteristic related to the unique mode of development of such tumours.…”