Correlation between lipid peroxidation-induced TBARS level and disease severity in obsessive–compulsive disorder

Chakraborty, Sutirtha; Singh, Om Prakash; Dasgupta, Anindya; Mandal, Nikhiles; Das, Harendra Nath

doi:10.1016/j.pnpbp.2009.01.001

Cited by 59 publications

(42 citation statements)

References 29 publications

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“…54,55 There have been reports of oxidative stress in populations with OCD, including increased lipid peroxidation; [56][57][58][59] decreased vitamin E, 58 catalase, GPx and selenium; 59 increased superoxide dismutase; 59 and changes in overall oxidative status. 60 Some of these alterations have been linked to symptom severity.…”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

“…60 Some of these alterations have been linked to symptom severity. 57,59 Standard first-line therapies for OCD generally include a combination of serotonin reuptake inhibitors (SRIs) and psychotherapy. Whereas there is some efficacy with this treatment regimen, up to 20% of individuals with OCD are treatment-resistant and derive little benefit.…”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

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N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

Dean

Giorlando

Berk

2011

J Psychiatry Neurosci

407

314

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There is an expanding field of research investigating the benefits of alternatives to current pharmacological therapies in psychiatry. N-acetylcysteine (NAC) is emerging as a useful agent in the treatment of psychiatric disorders. Like many therapies, the clinical origins of NAC are far removed from its current use in psychiatry. Whereas the mechanisms of NAC are only beginning to be understood, it is likely that NAC is exerting benefits beyond being a precursor to the antioxidant, glutathione, modulating glutamatergic, neurotropic and inflammatory pathways. This review outlines the current literature regarding the use of NAC in disorders including addiction, compulsive and grooming disorders, schizophrenia and bipolar disorder. N-acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited. The therapeutic potential of this acetylated amino acid is beginning to emerge in the field of psychiatric research.

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Section: Obsessive-compulsive Disordermentioning

confidence: 99%

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

Dean

Giorlando

Berk

2011

J Psychiatry Neurosci

407

314

View full text Add to dashboard Cite

show abstract

“…5 A substantial number of authors found increased amounts of markers of oxidative stress in plasma/serum, and/or deviations in the activity of defence enzymes in patients suffering from psychiatric disorders. 3,7,[15][16][17][18][19] A recent review by Hovatta et al…”

Section: Introductionmentioning

confidence: 99%

Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder

et al. 2014

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Background: The aim of this study was to measure the parameters of oxidative stress in the blood of patients with post-traumatic stress disorder. Methods: The study included 80 male war veterans who participated actively in the Homeland war in Croatia. Volunteers were divided into two groups: 50 veterans diagnosed with post-traumatic stress disorder and 30 without diagnosis. The self-assessment Hospital Anxiety and Depression Scale and the Beck Depression Inventory were used to detect the severity of depression and anxiety in the post-traumatic stress disorder patients. Catalytic concentrations of superoxide dismutase and glutathione peroxidase in erythrocytes and the concentration of malondialdehyde in serum were measured spectrophotometrically. Results: Although the catalytic concentrations of erythrocyte superoxide dismutase and erythrocyte glutathione peroxidase were within the reference range for both groups, the values obtained for the post-traumatic stress disorder group were significantly lower (P < 0.001). For serum malondialdehyde concentrations, no statistically significant differences between the groups were found. Conclusions: Lower catalytic concentrations of erythrocyte superoxide dismutase and erythrocyte glutathione peroxidase in patients with post-traumatic stress disorder may indicate a weaker response to oxidative stress due to impaired enzyme activity and/or decreased synthesis. Conversely, no significant changes in serum malondialdehyde concentrations suggest a compensated balance and adaptive response to (oxidative) stress.

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“…Chakraborty et al reported significantly higher mean values for serum TBARS in OCD patients than controls and a strong positive correlation between the lipid peroxidation marker TBARS and the disease severity indicator Yale Brown Obsessive Compulsive Scale (YBOCS) was found among cases 80 .…”

Section: Obsessive-compulsive Disordermentioning

confidence: 98%

Untitled

2011

IJPSR

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Lipid peroxidation (LPO) in cellular membranes is associated with changes in physicochemical properties and impairment of protein functions located in membrane environment. Recent studies shows involvement of LPO in biological signaling and various diseases. Lipids are oxidized by three distinct mechanisms: enzymatic oxidation; non-enzymatic, free radical-mediated oxidation and non-enzymatic, non radical oxidation. Lipids containing polyunsaturated fatty acids are susceptible to free radical-initiated oxidation and can participate in chain reactions that increase damage to biomolecules. Polyunsaturated fatty acids (PUFAs) and their metabolites have variety of physiological roles including: energy provision, membrane structure, cell signaling and regulation of gene expression. The present manuscript reviews concept of LPO with emphasis on implication in various diseases.

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Correlation between lipid peroxidation-induced TBARS level and disease severity in obsessive–compulsive disorder

Cited by 59 publications

References 29 publications

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder

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